Activate Now
 
ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Most Effective Treatment for Fibromyalgia Among Least Used Says Report

ACTION ALERT: Telling Your Chronic Pain Story Now is Important

Migraine, Fibromyalgia and ME/CFS

A NEW Form of Magnesium: Can It Help Brain Fog and Fibromyalgia Pain?

Allodynia and Fibromyalgia

Is Emergency Stress Impacting Your Fibromyalgia Body?

Have Doctors Gone Too Far on Exercise for Fibromyalgia?

Daily Non-Negotiables for Life with Chronic Illness

Update: S.483 Ensuring Patient Access and National Pain Strategy

Where Is Your Journey Taking You?

 
Print Page
Email Article

Lyrica and Statin Drug Combo Thought to Cause Rhabdomyolysis: A Case Report

  [ 3 votes ]   [ Discuss This Article ]
www.ProHealth.com • November 8, 2012


[Note: to read the full text of the article, click HERE ]

Article:

Pregabalin and simvastatin: first report of a case of rhabdomyolysis
– Source: Pharmacy and Therapeutics, October 2012

by Michele B. Kaufman and Mary Choy

Abstract:

Purpose: We sought to determine whether a case of rhabdomyolysis was a probable adverse reaction associated with pregabalin (Lyrica) and simvastatin (Zocor). [Note: Rhabdomyolysis is the breakdown of muscle fibers that leads to the release of muscle fiber contents (myoglobin) into the bloodstream. Myoglobin is harmful to the kidney and often causes kidney damage.] Pregabalin is not recognized as a cause of rhabdomyolysis, but statins are known to cause it.

 

Patient Summary: A 70-year-old man with a history of fibromyalgia, type-2 diabetes, hypercholesterolemia, and chronic back pain presented to the emergency department with altered mental status, limb weakness, twitching, and slurred speech.

 

He was taking multiple pain and neuropathic medications and had recently started taking lisinopril (e.g., Zestril) and simvastatin. His pregabalin dose was also increased from 50 mg to 100 mg three times daily. On admission, serum creatinine (SCr) and creatine phosphokinase (CPK) levels were 1.5 mg/dL (normal, 0.7-1.5 mg/dL) and 1,391 units/L (normal, 30-170 units/L), respectively. Metformin (Glucophage) was discontinued, and insulin was started.

 

He was alert and oriented. The review of symptoms was normal except for leg weakness. He had no seizure activity. Simvastatin was discontinued, and the patient was aggressively hydrated. The following day, the SCr level was 1.6 mg/dL and the CPK level was 14,191 units/L. Pregabalin was then discontinued.

 

The rhabdomyolysis resulted from simvastatin and perhaps also pregabalin. The Naranjo Causality Algorithm indicates a probable relationship between rhabdomyolysis and combined therapy. Three days later, the patient had significantly improved, and CPK began to decline. His discharge plan included all prior medications except simvastatin and pregabalin.

 

Conclusion: It is not well known that pregabalin can cause rhabdomyolysis, and there is only one published report on pregabalin-induced hepatotoxicity. [Note: The full-text article also states, “In the package labeling for pregabalin, three cases of rhabdomyolysis are noted in premarketing clinical trials; however, no further details are provided.”] When different therapies are combined, the risk of rhabdomyolysis may be increased.

 

The cause of rhabdomyolysis in our patient might be related to decreased renal elimination of both pregabalin and simvastatin (e.g., renal tubular reabsorption). It is important to be aware of this potentially serious and possibly life-threatening reaction especially when medication doses are increased or combined with other agents with similar safety issues.

Source: Pharmacy and Therapeutics. 2012 Oct; 37(10):579-95, by Michele B. Kaufman, PharmD and Mary Choy, PharmD.





Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ B-12 Extreme™ Guaifenesin FA™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
All Natural Deodorants

Featured Products

Fibro Freedom™ Fibro Freedom™
Soothes, Strengthens & Revitalizes
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Guaifenesin FA™ Guaifenesin FA™
Helps the Body Eliminate Excess Calcium and Phosphates
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth

Natural Remedies

Aching Muscles? Top 10 Nutrients to Take Back Your Life Aching Muscles? Top 10 Nutrients to Take Back Your Life
Herbal Inflammation Management for Whole Body Health Herbal Inflammation Management for Whole Body Health
Fatigue & Fibro Fog: Could You Have a B-12 Deficiency? Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?
Restore Youthful Cognition and Well-Being Restore Youthful Cognition and Well-Being
Block food Cravings At Their Molecular Root Block food Cravings At Their Molecular Root

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler

· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map