ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|

Trending News

You Might Have Fibromyalgia if...

A Link Between Dental Amalgams, Fibromyalgia, ME/CFS and Other Chronic Illnesses

Gait Characteristics of Women with Fibromyalgia: a Premature Aging Pattern

The Pain Brain: Hippocampal Atrophy Found in Fibromyalgia

The Myth of a Perfect Drug for Fibromyalgia or ME/CFS: the NNT Dilemma

VIDEO: Fibromyalgia in Pictures

Your voice matters! New Survey from National Fibromyalgia & Chronic Pain Association (NFMCPA)

Reduced Volume of Hippocampus May Be Related to Cognitive Problems in Fibromyalgia

VIDEO: Fibromyalgia Fitness: Your Simple 5-Step Exercise Plan

Asking for Help Is Giving a Gift

 
Print Page
Email Article

Lower Levels of ATP and PCr Found in Muscles of Fibromyalgia Patients

  [ 20 votes ]   [ Discuss This Article ]
www.ProHealth.com • February 7, 2013


[Note:  ATP stands for adenosine triphosphate, which is described as the energy currency of life.  Mitochondria are the energy producers in each cell and they supply this energy in the form of ATP.  PCr stands for phosphocreatinine, an organic compound found in muscle tissue that stores and provides energy for muscular contraction.]

Article:

Decreased muscle concentrations of ATP and PCR in the quadriceps muscle of fibromyalgia patients - A (31) P-MRS study.

– Source: European Journal of Pain, January 30, 2013

by G. Gerdle, et al.

Abstract:

BACKGROUND AND METHODS: Fibromyalgia (FMS) has a prevalence of approximately 2% in the population. Central alterations have been described in FMS, but there is not consensus with respect to the role of peripheral factors for the maintenance of FMS.

( 31) P Magnetic Resonance Spectroscopy ((31) P-MRS) has been used to investigate the metabolism of phosphagens in muscles of FMS patients, but the results in the literature are not in consensus. The aim was to investigate the quantitative content of phosphagens and pH in resting quadriceps muscle of patients with FMS (n?=?19) and in healthy controls (Controls; n?=?14) using (31) P-MRS. It was also investigated whether the concentrations of these substances correlated with measures of pain and/or physical capacity.

RESULTS:

  • Significantly lower concentrations of adenosine triphosphate (ATP) and phosphocreatinine (PCr; 28-29% lower) were found in FMS.

  • No significant group differences existed with respect to inorganic phosphate (Pi), Pi/PCr and pH.

  • The quadriceps muscle fat content was significantly higher in FMS than in Controls [FMS: 9.0?±?0.5% vs. Controls: 6.6?±?0.6%; (mean?±?standard error); P?=?0.005].

  • FMS had significantly lower hand and leg capacity according to specific physical test, but there were no group differences in body mass index, subjective activity level and in aerobic fitness.

  • In FMS, the specific physical capacity in the leg and the hand correlated positively with the concentrations of ATP and PCr; no significant correlations were found with pain intensities.

CONCLUSIONS: Alterations in intramuscular ATP, PCr and fat content in FMS probably reflect a combination of inactivity related to pain and dysfunction of muscle mitochondria.


Source: European Journal of Pain, January 30, 2013. B. Gerdle, M.F. Forsgren, A. Bengtsson, O.D. Leinhard, B. Soren, A. Karlsson, V. Brandejsky, E. Lund, P. Lundberg.  Rehabilitation Medicine, Department of Medicine and Health Sciences (IMH), Faculty of Health Sciences, Linköping University, Sweden; Pain and Rehabilitation Centre, UHL, Linköping, Sweden.




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Fibro Freedom™ Fibro Freedom™
Soothes, strengthens & revitalizes
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Guaifenesin FA™ Guaifenesin FA™
Natural Expectorant Relieves Chest Congestion
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid

Natural Remedies

Broad Spectrum Protection Against Brain Aging Broad Spectrum Protection Against Brain Aging
Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits
Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance
Fatigue & Fibro Fog: Could You Have a B-12 Deficiency? Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?
Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing