ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|

Trending News

Where Fibromyalgia and Chronic Fatigue Syndrome Part Ways (and Where They Don't)

Autoimmune Research Opening Up New Options for Chronic Pain Sufferers

Celiac Symptoms in Fibromyalgia Patients

Does Fibromyalgia Diet = Deprivation?

Why Pain, Fatigue, FibroFog, and Sleep Are Results Symptoms

Prevalence of Falls in Fibromyalgia Patients

FDA Approves New Type of Sleep Medication

How to Become a Fibromyalgia Truth Sleuth

VIDEO: Healthy Eating and Fibromyalgia

Accepting and Surviving Chronic Illness

 
Print Page
Email Article

Enhanced Glutathione Levels in Blood and Buccal Cells by Oral Glutathione Supplementation

  [ 8 votes ]   [ Discuss This Article ]
By John P Richie et al. • www.ProHealth.com • June 20, 2013


By John P Richie et al.

Abstract

Glutathione (GSH) is the major antioxidant in nearly all cells and plays numerous roles in protection against diseases and biological insults. Previous studies in laboratory animals indicate that orally administered GSH is bioavailable and effective at enhancing tissue GSH levels. The current objective was to determine the efficacy of GSH supplementation at enhancing body stores of GSH in healthy adults.

We conducted a 6-mo randomized, double-blind, placebo controlled trial to determine the impact of GSH administration at 250 mg/day and 1000 mg/day on GSH levels in different blood components and exfoliated buccal mucosal cells. Subjects were 54 healthy adults (41 females/13 males), 28–72 yr of age (mean=46.6 yr). Compliance was >90% by pill count.

After 6 mo in the high dose group, GSH levels were increased 30–35% in RBC, plasma, and lymphocytes and 260% in buccal cells (P<0.05). In most cases, the increases were dose and time dependent and levels returned to baseline after a 1-month washout. No significant changes were observed in levels of protein bound GSH.

A battery of immune function markers was also examined after 3 mo of GSH supplementation and Natural Killer (NK) cytotoxicity was enhanced > 2-fold in the high dose group (P<0.05). Altogether, these findings are consistent with previous pre-clinical studies and indicate that long-term oral administration GSH is an effective means of enhancing body stores of GSH.

Source: The FASEB Journal. 2013;27:862.32. John P Richie, Sailnendra Nichenametla, Ana Calcagnotto, Wanda Neidig, Todd Schell, and Joshua E Muscat




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Your Next Order

Featured Products

FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness

Natural Remedies

IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10
Sunshine Vitamin Has D-lightful Health Benefits Sunshine Vitamin Has D-lightful Health Benefits
"It's Not Easy Being Green" - But It Is Healthy
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing