ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

When a Setback Drags On….and On

Fibromyalgia expert says misdiagnosis is rampant - Part 1

8 Types of Fibromyalgia Pain

5 Quotes That Keep Me Strong When I Feel Like Giving Up

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery

Fibromyalgia – Does It Get Better?

Impact of pain misunderstood by public, NFCPA survey shows

VIDEO: Chronic Pain Coping Methods

Fibromyalgia expert says misdiagnosis is rampant - Part 2

Dance for Adults with Fibromyalgia – What Do We Know About It? Protocol for a Scoping Review.

 
Print Page
Email Article

Thermoregulation and Pain Modulation in Fibromyalgia

  [ 3 votes ]   [ 2 Comments ]
www.ProHealth.com • August 3, 2013


Review of Overlap Between Thermoregulation and Pain Modulation in Fibromyalgia.

By Alice A. Larson, PhD; José V. Pardo, MD, PhD; and Jeffrey D. Pasley, PhD

Abstract:

Fibromyalgia (FM) syndrome is characterized by widespread pain that is exacerbated by cold and stress but relieved by warmth. We review the points along thermal and pain pathways where temperature may influence pain. We also present evidence addressing the possibility that brown adipose tissue activity is linked to the pain of FM given that cold initiates thermogenesis in brown adipose tissue through adrenergic activity, whereas warmth suspends thermogenesis.

Although females have a higher incidence of FM and more resting thermogenesis, they are less able to recruit brown adipose tissue in response to chronic stress than males. In addition, conditions that are frequently comorbid with FM compromise brown adipose activity making it less responsive to sympathetic stimulation. This results in lower body temperatures, lower metabolic rates, and lower circulating cortisol/corticosterone in response to stress-characteristics of FM.

In the periphery, sympathetic nerves to brown adipose also project to surrounding tissues, including tender points characterizing FM. As a result, the musculoskeletal hyperalgesia associated with conditions such as FM may result from referred pain in the adjacent muscle and skin.

Source: The Clinical Journal of Pain, July 24, 2013. By Alice A. Larson, PhD; José V. Pardo, MD, PhD; and Jeffrey D. Pasley, PhD. Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul §Department of Physiology and Pharmacology, University of Minnesota, Duluth ‡Departments of Psychiatry, University of Minnesota †Mental Health Patient Service Line, VA Medical Center, Minneapolis, MN.





Post a Comment

Featured Products From the ProHealth Store
Fibro Freedom™ Hydroxocobalamin Extreme™ Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

Referred pain???
Posted by: IanH
Aug 3, 2013
" As a result, the musculoskeletal hyperalgesia associated with conditions such as FM may result from referred pain in the adjacent muscle and skin."

For me, I require a plausible explanation of the suggesttion of referred pain.

Many people with FM do not worsen with the cold and some people with FM are quite intolerant of higher temperatures found in the semi and tropical countries. Also we have found that some people with FM cannot tolerate thermal pools used for arthritic paliative treatments.

Overall I am doubtful of this hypothesis as a significant factor in FM.
Reply Reply

Flawed premise
Posted by: ProHealth-Editor
Aug 4, 2013
I, too, have doubts about this study. I think the premise upon which the study is based – that FM "is characterized by widespread pain that is exacerbated by cold...but relieved by warmth" – is flawed.

While most FM patients do seem to be sensitive to cold, some (like myself) feel best when it is cold and are hyper-sensitive to heat. Therefore, this hypothesis is not applicable to all FM patients.
Reply Reply
 
NAD+ Ignite with Niagen

Featured Products

Guaifenesin FA™ Guaifenesin FA™
Helps the Body Eliminate Excess Calcium and Phosphates
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Fibro Freedom™ Fibro Freedom™
Soothes, Strengthens & Revitalizes

Natural Remedies

Joint Aches May Have Met Their Match in Curcumin Joint Aches May Have Met Their Match in Curcumin
Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask
The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away
How Glutathione Can Save Your Life How Glutathione Can Save Your Life
Green Coffee Extract: Unique Obesity Intervention Green Coffee Extract: Unique Obesity Intervention

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map