Reprinted with kind permission of Life Extension, January 2014.
Studies described in the December 2013 issue of The Journal of Nutritional Biochemistry add evidence to a benefit for pyrroloquinoline quinone (PQQ), a compound that activates factors involved in the regulation of cellular energy metabolism and mitochondria formation, in reducing inflammation and enhancing mitochondrial function. (Mitochondria are the cells' energy-producing organelles.)
In their introduction to the article, Calliandra B. Harris and colleagues from the University of California, Davis observe that the reduced form of PQQ is a potent antioxidant. "It is also noteworthy that there may have been a constant exposure to PQQ-like compounds throughout biological evolution based on the observations that stellar dust contains PQQ-like compounds," they remark.
Dr Harris and associates note that while the mechanisms of PQQ in energy-related metabolism and neurologic functions in animals have been explored, its mechanisms of action in humans had not been confirmed.
In one study, five men and five women ingested a single dose of PQQ and changes in antioxidant potential were measured in plasma samples collected over the following 48 hours. A decrease in plasma thiobarbituric acid reactive products (TBARS) was observed over time, indicating a reduction in oxidative stress in comparison with presupplementation levels.
In a second study, PQQ was administered daily for three days. Blood samples obtained before and after treatment were analyzed for markers of inflammation and a number of metabolites were measured in urinary samples obtained during the same time points. A significant decline in post-treatment C-reactive protein and interleukin-6 levels occurred indicating a decrease in the inflammatory response. The researchers also documented alterations in urinary metabolites that indicated improvements in mitochondrial efficiency.
"The data reported are among the first to link systemic effects of PQQ in animals to related or corresponding effects in humans," the authors announce. "The data herein support the hypothesis that human subjects respond rapidly to PQQ supplementation with changes in urinary metabolites consistent with enhanced mitochondria related functions."
For more information about PQQ, see “Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
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