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Brain Structure Shows Who Is Most Sensitive to Pain

  [ 7 votes ]   [ 1 Comment ]
www.ProHealth.com • March 12, 2014


Brain Structure Shows Who Is Most Sensitive to Pain. Image by
Image by "Victor Habbick" courtesy of FreeDigitalPhotos.net
WINSTON-SALEM, N.C. – Jan. 14, 2014 – Everybody feels pain differently, and brain structure may hold the clue to these differences.

In a study published in the current online issue of the journal Pain, scientists at Wake Forest Baptist Medical Center have shown that the brain’s structure is related to how intensely people perceive pain.

“We found that individual differences in the amount of grey matter in certain regions of the brain are related to how sensitive different people are to pain,” said Robert Coghill, Ph.D., professor of neurobiology and anatomy at Wake Forest Baptist and senior author of the study.

The brain is made up of both grey and white matter. Grey matter processes information much like a computer, while white matter coordinates communications between the different regions of the brain.

The research team investigated the relationship between the amount of grey matter and individual differences in pain sensitivity in 116 healthy volunteers. Pain sensitivity was tested by having participants rate the intensity of their pain when a small spot of skin on their arm or leg was heated to 120 degrees Fahrenheit. After pain sensitivity testing, participants underwent MRI scans that recorded images of their brain structure.

“Subjects with higher pain intensity ratings had less grey matter in brain regions that contribute to internal thoughts and control of attention,” said Nichole Emerson, B.S., a graduate student in the Coghill lab and first author of the study. These regions include the posterior cingulate cortex, precuneus and areas of the posterior parietal cortex, she said.

The posterior cingulate cortex and precuneus are part of the default mode network, a set of connected brain regions that are associated with the free-flowing thoughts that people have while they are daydreaming.

“Default mode activity may compete with brain activity that generates an experience of pain, such that individuals with high default mode activity would have reduced sensitivity to pain,” Coghill said.

Areas of the posterior parietal cortex play an important role in attention. Individuals who can best keep their attention focused may also be best at keeping pain under control, Coghill said.

“These kinds of structural differences can provide a foundation for the development of better tools for the diagnosis, classification, treatment and even prevention of pain,” he said.

The study was supported by the National Institutes of Health grants NS039426 and DA020168 and the U.S.-Israel Binational Science Foundation grant 2009097.

Co-authors include Fadel Zeidan, Ph.D., Oleg Lobanov, Ph.D., Morten Hadsel, Ph.D., Katherine Martucci, Ph.D., Alexandre Quevedo, Ph.D., and Christopher Starr, Ph.D., of Wake Forest Baptist; Hadas Nahman-Averbuch, M.S., Yelena Granovsky, Ph.D., and David Yarnitsky, Ph.D., of Technion Faculty of Medicine, Haifa, Israel; and Irit Weissman-Fogel, Ph.D., of University of Haifa.

Pain sensitivity is inversely related to regional grey matter density in the brain

Summary: Highly sensitive individuals had the least grey matter density in the bilateral precuneus, posterior cingulate cortex, posterior parietal cortex, and left primary somatosensory cortex.

Abstract:

Pain is a highly personal experience that varies substantially among individuals. In search of an anatomical correlate of pain sensitivity, we used voxel-based morphometry to investigate the relationship between grey matter density across the whole brain and interindividual differences in pain sensitivity in 116 healthy volunteers (62 women, 54 men).

Structural magnetic resonance imaging (MRI) and psychophysical data from 10 previous functional MRI studies were used. Age, sex, unpleasantness ratings, scanner sequence, and sensory testing location were added to the model as covariates.

Regression analysis of grey matter density across the whole brain and thermal pain intensity ratings at 49°C revealed a significant inverse relationship between pain sensitivity and grey matter density in bilateral regions of the posterior cingulate cortex, precuneus, intraparietal sulcus, and inferior parietal lobule. Unilateral regions of the left primary somatosensory cortex also exhibited this inverse relationship. No regions showed a positive relationship to pain sensitivity. These structural variations occurred in areas associated with the default mode network, attentional direction and shifting, as well as somatosensory processing.

These findings underscore the potential importance of processes related to default mode thought and attention in shaping individual differences in pain sensitivity and indicate that pain sensitivity can potentially be predicted on the basis of brain structure.

Source: Pain, March 2014. Nichole M. Emerson, Fadel Zeidan, Oleg V. Lobanov, Morten S. Hadsel, Katherine T. Martucci, Alexandre S. Quevedo, Christopher J. Starr, Hadas Nahman-Averbuch, Irit Weissman-Fogel, Yelena Granovsky, David Yarnitsky, Robert C. Coghill. Department of Neuroscience, Wake Forest University School of Medicine, Winston-Salem, NC, USA.




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Article Comments Post a Comment

Brain structure and pain sensitivity
Posted by: DrNoSA
Apr 9, 2014
Based on current findings in patients with obstructive sleep apnea (OSA), I wouldn't be surprised if these patients with reduced brain volume have untreated OSA themselves. I recommend sleep studies and CPAP for those who have the disorder. Look for reversal of their brain defects after a year of treatment.
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