Activate Now
 
ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Fibromyalgia: The body holding on to past trauma

10 Fast Facts: Fibromyalgia Is Real

Ten Tips to Simplify, Lower the Cost, and Optimize CFS and fibromyalgia Treatment

Sleep, oh sleep, where art thou? Could your fibromyalgia medications be causing insomnia?

Patient Insights into the Design of Technology to Support a Strengths-Based Approach to Health Care.

How to Obtain Relief for Fibromyalgia - Part 1: Complementary and Alternative Therapies

3 Genetic Reset Methods Your Doctor Should Prescribe for Fibromyalgia

Keep Learning – Even From Bed!

Buying Drugs from Canada - A Good Choice for Fibromyalgia and Chronic Fatigue Syndrome (ME/CFS)?

VIDEO: Dear Healthy People: Fatigue

 
Print Page
Email Article

Are ME/CFS and fibromyalgia tryptophan-associated disorders?

  [ 13 votes ]   [ 1 Comment ]
www.ProHealth.com • October 6, 2012


Article:
A Brief Historic Overview of Clinical Disorders Associated with Tryptophan: The Relevance to Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM)
- Source: International Journal of Tryptophan Research, Sep 17, 2012

By Adele Blankfield, BSc

[Note: The full text PDF of this article is available free HERE. It reviews research suggesting that up-regulation of the ‘kynurenine pathway’ may play a role in the clusters of signs and symptoms that predominate in ME/CFS and fibromyalgia patients.

What is the kynurenine pathway? It’s complex, but we located this brief video by biochemist Wesley Hurrell which diagrams the pathway; how its chronic up-regulation may lead to tryptophan and serotonin depletion & produce chronic Th1-immune activation; and the association with symptoms common in ME/CFS and fibromyalgia, including IBS, cognitive impairment, sleep disturbances and depression.]

Abstract:
Last century there was a short burst of interest in the tryptophan-related disorders of pellagra and related abnormalities that are usually presented in infancy.1,2 [L-Tryptophan is an essential amino acid that is a precursor to many neurotransmitters and neurochemicals, including serotonin and melotonin.]

Nutritional physiologists recognized that a severe human dietary deficiency of either tryptophan or the B group vitamins could result in central nervous system (CNS) sequelae such as ataxia [lack of muscle coordination], cognitive dysfunction and dysphoria [anxiety/restlessness], accompanied by skin hyperpigmentation.3,4

The current paper will focus on the emerging role of tryptophan in chronic fatigue syndrome (CFS) and fibromyalgia (FM).

Source: International Journal of Tryptophan Research, Sep 17, 2012; 5, 27-32. DOI: 10.4137/IJTR.S10085, by Blankfield A. Kew, Australia. [Email: gjshnier@bigpond.net.au]





Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ B-12 Extreme™ Fibro Freedom™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

Problems with tryptophan beyond kynurenine
Posted by: RolfHefti
Oct 7, 2012
The many problems related to kynurenine are just one of the problematic issues with tryptophan.

This research paper seems to insinuate that tryptophan itself isn't a problem (inferred from observed effects of an endogenous tryptophan deficiency), but primarily the chronic release of kynurenines. However, serotonin, for which tryptophan is its precursor, has been shown to be involved in numerous disease conditions, from brain degeneration, cancer, cardiovascular events, and many others (see http://www.supplements-and-health.com/tryptophan-side-effects.html). This doesn't indicate that the loading of tryptophan or serotonin, with drugs or dietary supplements, is biologically desired.
Reply Reply
 
Natural Pain Relief Supplements

Featured Products

B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Fibro Freedom™ Fibro Freedom™
Soothes, Strengthens & Revitalizes
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Guaifenesin FA™ Guaifenesin FA™
Helps the Body Eliminate Excess Calcium and Phosphates
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Guarding Against the Dangers of Vitamin D Deficiency Guarding Against the Dangers of Vitamin D Deficiency
When a Good Night's Sleep Is Just a Daydream... When a Good Night's Sleep Is Just a Daydream...
Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire Natural Relief for Soreness, Pain and Swelling - Putting Out the Fire
Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?
Vitamin K-2 – A Key Player in Cardiovascular and Bone Health Vitamin K-2 – A Key Player in Cardiovascular and Bone Health

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map