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Strong Evidence of a Genetic Link in Fibromyalgia

  [ 63 votes ]   [ 2 Comments ] • January 4, 2013

Strong Evidence of a Genetic Link in FibromyalgiaArticle:

The fibromyalgia family study: A genome-scan linkage study.

– Source:  Arthritis and Rheumatism, December 28, 2012. [Epub ahead of print]

By Lesley M. Arnold, et al.


Objective:  Familial aggregation of fibromyalgia has been increasingly recognized. The goal of the current study was to conduct a genome wide linkage scan to identify susceptibility loci for fibromyalgia.

Methods:  We genotyped members of 116 families from the Fibromyalgia Family Study and performed a model-free genome-wide linkage analysis of fibromyalgia with 341 microsatellite markers, using the Haseman-Elston regression approach.

Results:  The estimated sibling recurrence risk ratio (?(s) ) for fibromyalgia was 13.6 (95% CI: 10.0-18.5), based on a reported population prevalence of 2%. Genome-wide suggestive evidence of linkage was found at marker D17S2196 (Empirical P =0.00030) and D17S1294 (Empirical P =0.00035) on chromosome 17p11.2-q11.2.

Conclusion:  The estimated sibling recurrence risk ratio suggests a strong genetic component of fibromyalgia.

This is the first study to report genome-wide suggestive linkage of fibromyalgia to the chromosome 17p11.2-q11.2 region.

Further investigation of these multi-case families from the Fibromyalgia Family Study is warranted to identify potential causal risk variants for fibromyalgia. © 2012 American College of Rheumatology.

Source:  Arthritis and Rheumatism, December 28, 2012. [Epub ahead of print]. By Lesley M. Arnold, I. Jon Russell, Muhammad B. Yunus, M.A. Khan, I. Kushner, J.M. Olson, S.K. Iyengar. Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, Ohio. E-mail:

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Article Comments Post a Comment

nice to know
Posted by: roge
Jan 4, 2013
genetic link was highly suspected for years and good to get more confirmation but researchers what are you doing to help better treat this horrible disease and gain a better understanding of the pathology . I can assure everyone with FM would rather have that answered then if this runs in families - can we please get come priority setting here with regards to how research dollars are spent here - man o man.
Reply Reply

"Genetic link?" I hope to shout!
Posted by: tursiops
Jan 16, 2013
I got sick in June 1981, at age 42. My daughter got sick several years later, at age 34. Within a year, she was no longer
able to work.
Recently, she has in addition, been diagnosed with MS.

My son, a few years later, came down with it too, he was 42.

And can anybody help me get the full spectrum of tests for hypo-
thyrodism? My doctor absolutely REFUSES to do anything but the
THS test,citing it as the most 'sensitive.' Everything I've read
about it shows that, if you don't know the results of the T3, T4
tests, you aren't getting the full picture. And, given that I am
a tall, plus size lady, does the dosage for thyroid replacement
for a 5' tall, 98 pound person seem adequate for someone larger?
I have taken him articles written by doctors, for doctors, and
he won't even read them. Why do I keep him as my PCP? I live in
a rural area. Only choice.
Reply Reply
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