ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Why I Quit Taking Cymbalta for Fibromyalgia

The fibro symptom that scares me most

10 Things to Try When You're Feeling Lonely

Inflammation Disrupts Memory - What Can You Do to Protect Your Brain?

Dr. Liptan on Low Dose Naltrexone’s Effectiveness in Fibromyalgia and the “Opiate LDN Quagmire”

Effects of Vitamin D Therapy on Quality of Life in Patients with Fibromyalgia.

Invisible: Interview with Filmmaker Nick Demos

Cultivating Trust to Make your NOW Better

Century-old vaccine gives new hope to fibromyalgia community

Hypnosis for Fibromyalgia

 
Print Page
Email Article

Lipid Peroxidation in Blood Mononuclear Cells Associated with Fibromyalgia Symptoms

  [ 1 vote ]   [ Discuss This Article ]
www.ProHealth.com • May 10, 2013


Editor's comment:  Many studies have shown high levels of oxidative stress in fibromyalgia patients.  Oxidative stress is usually determined by measuring lipid peroxidation (LPO) in blood plasma.  [Lipid peroxidation is the process in which free radicals “steal” electrons from the lipids in cell membranes, causing damage to the cells.]  However, there have been some discrepancies about the correlation between FM symptoms and LPO using this method.  This study was undertaken to determine whether measuring LPO in the cells themselves – specifically blood mononuclear cells – rather than in the plasma would result in a more consistent correlation between LPO and the clinical symptoms of FM.  [Blood mononuclear cells (BMCs) are any blood cells that have a round nucleus, including lymphocytes, monocytes and macrophages.  BMCs are a critical component of the immune system.] 

Note: You may read the full text of this article free HERE.

Clinical Symptoms in Fibromyalgia Are Better Associated to Lipid Peroxidation Levels in Blood Mononuclear Cells Rather than in Plasma

By Mario D. Cordero, et al.
 
Abstract:

Background: We examined lipid peroxidation (LPO) in blood mononuclear cells (BMCs) and plasma, as a marker of oxidative damage, and its association to clinical symptoms in Fibromyalgia (FM) patients.

Methods: We conducted a case–control and correlational study comparing 65 patients and 45 healthy controls. Clinical parameters were evaluated using the Fibromyalgia Impact Questionnaire (FIQ), visual analogues scales (VAS), and the Beck Depression Inventory (BDI). Oxidative stress was determined by measuring LPO in BMCs and plasma.

Results: We found increased LPO levels in BMCs and plasma from FM patients as compared to normal control (P<0.001).

  • A significant correlation between LPO in BMCs and clinical parameters was observed (r = 0.584, P<0.001 for VAS; r = 0.823, P<0.001 for FIQ total score; and r = 0.875, P<0.01 for depression in the BDI).

  • We also found a positive correlation between LPO in plasma and clinical symptoms (r = 0.452, P<0.001 for VAS; r = 0.578, P<0.001 for FIQ total score; and r = 0.579, P<0.001 for depression in the BDI).

  • Partial correlation analysis controlling for age and BMI, and sex, showed that both LPO in cells and plasma were independently associated to clinical symptoms.

  • However, LPO in cells, but not LPO in plasma, was independently associated to clinical symptoms when controlling for depression (BDI scores).

Discussion: The results of this study suggest a role for oxidative stress in the pathophysiology of fibromyalgia and that LPO in BMCs rather than LPO in plasma is better associated to clinical symptoms in FM.

Source: PloS ONE, October 28, 2011. By Mario D. Cordero, Elísabet Alcocer-Gómez, Francisco J. Cano-García, Manuel De Miguel, Angel M. Carrión, Plácido Navas and José A. Sánchez Alcázar. Hospital Vall d?Hebron, Spain.





Post a Comment

Featured Products From the ProHealth Store
Fibro Freedom™ FibroSleep™ Hydroxocobalamin Extreme™


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
Fibro Freedom™ Fibro Freedom™
Soothes, Strengthens & Revitalizes
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle
Fighting Fatigue with Ground-breaking French Oak Wood Extract Fighting Fatigue with Ground-breaking French Oak Wood Extract
Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map