Activate Now
 
ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

The Legs of Fibromyalgia and Myofascial Pain

The Fatigue and Pain Hormone? Leptin Shows Up Again – in Fibromyalgia

Our Mind Wants What Our Body Can't Produce

Relief for Dry, Itchy Skin Caused by Fibromyalgia

Reversing Alzheimer’s: What Could it Mean for Chronic Fatigue Syndrome (ME/CFS) and Fibromyalgia?

VIDEO: Fibromyalgia Warnings

4 Simple Ways to Shift into Positivity

Recovering from Chronic Fatigue Syndrome and Fibromyalgia - The Lerner Way

VIDEO: "I Live with Pain Everyday" (Stories of Fibromyalgia)

3 Reasons Why Fibromyalgia May Affect Women More Than Men

 
Print Page
Email Article

Norepinephrine Reuptake Inhibitors Have Negative Effect on Postural Tachycardia Syndrome (POTS)

  [ 5 votes ]   [ 1 Comment ]
www.ProHealth.com • September 5, 2013


Editor's comment:  Postural Tachycardia Syndrome (POTS), a form of orthostatic intolerance, often occurs with fibromyalgia and ME/CFS.  Since serotonin and norepinephrine reuptake inhibitors like Cymbalta and Savella are frequently prescribed for fibromyalgia, it is important to know that they may worsen POTS symptoms. 

Note: You may read the full text of this article free HERE.

Effects of norepinephrine reuptake inhibition on postural tachycardia syndrome.

By Elizabeth A. Green, et al.

Abstract:

BACKGROUND: Postural tachycardia syndrome (POTS) is a disorder of chronic orthostatic intolerance accompanied by excessive orthostatic tachycardia. Patients with POTS commonly have comorbid conditions such as attention deficit hyperactivity disorder, depression, or fibromyalgia that are treated with medications that inhibit the norepinephrine reuptake transporter (NRI). NRI medications can increase sympathetic nervous system tone, which may increase heart rate (HR) and worsen symptoms in POTS patients. We sought to determine whether NRI with atomoxetine increases standing tachycardia or worsens the symptom burden in POTS patients.

METHODS AND RESULTS: Patients with POTS (n=27) underwent an acute drug trial of atomoxetine 40 mg and placebo on separate mornings in a randomized, crossover design. Blood pressure (BP), HR, and symptoms were assessed while seated and after standing prior to and hourly for 4 hours following study drug administration.

  • Atomoxetine significantly increased standing HR compared with placebo (121±17 beats per minute versus 105±15 beats per minute; P=0.001) in POTS patients, with a trend toward higher standing systolic BP (P=0.072).

  • Symptom scores worsened with atomoxetine compared to placebo (+4.2 au versus -3.5 au; P=0.028) from baseline to 2 hours after study drug administration.

CONCLUSION: Norepinephrine reuptake inhibition with atomoxetine acutely increased standing HR and symptom burden in patients with POTS.

Source: Journal of the American Heart Association, September 3, 2013. By Elizabeth A. Green, Beng; Vidya Raj, MB, ChB; Cyndya A. Shibao, MD, MSCI; Italo Biaggioni, MD; Bonnie K. Black, RN, CNP; William D. Dupont, PhD; David Robertson, MD; Satish R. Raj, MD, MSC. Autonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, TN.




Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Optimized Curcumin Longvida® Guaifenesin FA™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

Serotonin Norepinephrine reuptake inhibitors (SNRI's)
Posted by: cmesmile
Sep 24, 2013
I am just curious if SNRI's would also have the same effect on POTS symptoms? I am on Effexor XR and have been diagnosed with POTS and CFIDS. I have not noticed any major issues, but have not been on it that long. Does anyone have info on SNRI's?
Reply Reply
 
Natural Pain Relief Supplements

Featured Products

Fibro Freedom™ Fibro Freedom™
Soothes, Strengthens & Revitalizes
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness

Natural Remedies

Milk Thistle: Trusted Support for Health & Healing in a Toxic World Milk Thistle: Trusted Support for Health & Healing in a Toxic World
Priming Your Immune System for Cold & Flu Season Priming Your Immune System for Cold & Flu Season
D-ficient? Health Risks You Need to Know About D-ficient? Health Risks You Need to Know About
Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen
Coping When Colds or Flu Catch Up with You Coping When Colds or Flu Catch Up with You

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map