ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Eli Lilly Settles Cymbalta Withdrawal Lawsuits

Top Fibromyalgia Drug Tanks: Four Other Drugs On Way

When Retreat Means Advance: A Recovered Chronic Fatigue Syndrome/Fibromyalgia Patient Looks Back

A Genetic Panel for Fibromyalgia? The New Proove Genetic Test

Fibromyalgia Life Lessons - What You Need to Know.

Creating Intimacy Through Mindful Touch When You Live with Chronic Illness

The Psychosocial Disease – Has Fibromyalgia Been Captured by a Behavioral Paradigm?

Genes May Be Causing Neuroinflammation and Pain in Fibromyalgia

3 Fibromyalgia Struggles I’m Glad I Had

VIDEO: How does your brain respond to pain?

Print Page
Email Article

Fibromyalgia Drug Savella May Also Help Prevent Migraines

  [ 4 votes ]   [ 1 Comment ] • October 25, 2013

Editor's Comment:  Savella (milnacipran), an antidepressant, was the third drug to receive FDA approval for the treatment of fibromyalgia.  In this pilot study, researchers tested the effectiveness of milnacipran for reducing the frequency of episodic or chronic migraines.  Since a significant number of people with fibromyalgia also have migraines, a drug that could do double duty would be a plus. 

A prospective, open-label study of milnacipran in the prevention of headache in patients with episodic or chronic migraine.

By Emily Rubenstein Engel, David Kudrow and Alan M. Rapoport


Migraine is a highly prevalent episodic and chronic neurological disorder that impacts otherwise healthy men and women in their most productive years. An anecdotal survey in our clinical practices suggested that milnacipran, a drug indicated for the treatment of fibromyalgia, reduced the incidence of headache in patients with migraine.

In this 3-month, open-label, pilot study, 38 patients diagnosed with episodic migraine and 7 patients with chronic migraine maintained headache diaries to assess the effectiveness and tolerability of milnacipran in headache prevention. After a 1-month period to obtain baseline data, milnacipran treatment was initiated and doses were titrated up to 100  mg/day over 1  month. Maintenance therapy continued for an additional 3  months. The primary efficacy end point was change from baseline in the number of all headache days during the last 28  days of maintenance therapy analyzed, using last observation carried forward (LOCF). Change from baseline in migraine days during the last month of the maintenance period using LOCF was a secondary end point.

Milnacipran 100  mg daily was associated with a significant reduction in headache (-4.2  days; P  <  0.001) and migraine frequency (-2.2  days; P  <  0.003). The adverse event profile was consistent with prior reports of milnacipran for the treatment of other conditions. However, compared with the recommended protocol, a more gradual increase in milnacipran dose was required to improve tolerability for some patients.

The robust efficacy signal found in this study strongly suggests that a double-blind, placebo-controlled trial of milnacipran in migraine and chronic headache is warranted.

Source: Neurological Sciences, September 2013. By Emily Rubenstein Engel, David Kudrow and Alan M. Rapoport.  Dalessio Headache Center, Scripps Clinic, 10666 North Torrey Pines Rd. MS 313, La Jolla, CA, 92037, USA.

Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ B-12 Extreme™ Fibro Freedom™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments Post a Comment

Ginger helps HypoGal with Pain
Posted by: HypoGal
Oct 28, 2013
I have tried numerous medications to stop the Fibro pain. Unfortunately, I have not found the correct combo. I have tried Savella but the medication was not successful for me.
I believe my Fibro is link to inflammation in my body. I also believe my Fibro is secondary. I was stricken with Fibro after I developed Sheehan's Syndrome.
I have been eating about a half cup of raw ginger daily. I have found that ginger has helped with my pain from Relapsing Polychondritis.
I hope Savella can help others with Fibro
Reply Reply
Natural Pain Relief Supplements

Featured Products

B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
Fibro Freedom™ Fibro Freedom™
Soothes, Strengthens & Revitalizes
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

The New Dual Activation Pain Relief Cream The New Dual Activation Pain Relief Cream
Optimize Your Immune System Naturally: Thymic Protein A Optimize Your Immune System Naturally: Thymic Protein A
Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
"It's Not Easy Being Green" - But It Is Healthy
Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt Cocoa's Polyphenol Riches - All the Health Benefits without the Sugar, Calories or Guilt

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map