Activate Now
 
ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

15 tips for cooking and cleaning your kitchen when you’re chronically ill

Meet Beth Beale, aka Dear Fibromyalgia

ProHealth Announces Its 2015 Fibromyalgia Advocate of the Year: Jan Chambers!

The Romance of Fibromyalgia and T'ai Chi

Fibromyalgia Immune Blood Test Going Mainstream?

May is Fibromyalgia Awareness Month

Can mastalgia be another somatic symptom in fibromyalgia syndrome?

When the Joy Just Isn’t Getting Through

The New Dual Activation Pain Relief Cream

20 Date Night Ideas for Chronic Illness

 
Print Page
Email Article

Hyperexcitable C Nociceptors in Fibromyalgia

  [ 10 votes ]   [ Discuss This Article ]
By Jordi Serra, MD, et al. • www.ProHealth.com • December 9, 2013


Editor's comment:  Nociceptors are nerve cells that respond to potentially damaging stimuli by sending  signals – usually perceived as pain – to the brain and spinal cord.  In this study, researchers found that the function of certain nociceptors is abnormal in most people with fibromyalgia. 

Abstract:

Objective: To test the hypothesis that peripheral C nociceptor function may be abnormal in fibromyalgia and that C nociceptor dysfunction may contribute to the symptoms reported by these patients.

Methods: Microneurography was used to record from C nociceptors of 30 female patients meeting criteria for fibromyalgia and compared with recordings from 17 female patients with small fiber neuropathy and 9 female controls.

Results: We obtained stable recordings from 186 C nociceptors in the fibromyalgia group, 114 from small fiber neuropathy patients, and 66 from controls.

  • The mechano-sensitive nociceptors in the fibromyalgia patients behaved normally, but the silent nociceptors in 76.6% of fibromyalgia patients exhibited abnormalities.

  • Spontaneous activity was detected in 31% of silent nociceptors in fibromyalgia, 34% in small fiber neuropathy, and 2.2% in controls.

  • Sensitization to mechanical stimulation was found in 24.2% of silent nociceptors in fibromyalgia, 22.7% in small fiber neuropathy, and 3.7% in controls.

  • Abnormally high slowing of conduction velocity when first stimulated at 0.25 Hz was more common in fibromyalgia.

Interpretation: We show for the first time that the majority of fibromyalgia patients have abnormal C nociceptors. Many silent nociceptors exhibit hyperexcitability resembling that in small fiber neuropathy, but high activity-dependent slowing of conduction velocity is more common in fibromyalgia patients, and may constitute a distinguishing feature. We infer that abnormal peripheral C nociceptor ongoing activity and increased mechanical sensitivity could contribute to the pain and tenderness suffered by patients with fibromyalgia.

Source:
Annals of Neurology, November 16, 2013. By Jordi Serra MD, Antonio Collado MD, Romà Solà MD, Francesca Antonelli MD, Xavier Torres MD, Monika Salgueiro MD, Cristina Quiles MD and Hugh Bostock PhD, FRS. Department of Neurology, MC Mutual, Barcelona, Spain; Neuroscience Technologies, Parc Científic de Barcelona, Barcelona.





Post a Comment

Featured Products From the ProHealth Store
Fibro Freedom™ Optimized Curcumin Longvida® B-12 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Aching for Pain Relief?

Featured Products

Fibro Freedom™ Fibro Freedom™
Soothes, Strengthens & Revitalizes
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love
Guarding Against the Dangers of Vitamin D Deficiency Guarding Against the Dangers of Vitamin D Deficiency
Coenzyme Q10 - The Energy Maker Coenzyme Q10 - The Energy Maker
Fatigue & Fibro Fog: Could You Have a B-12 Deficiency? Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?
Complete and Natural Menopause Relief Complete and Natural Menopause Relief

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler

· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map