ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Why I Quit Taking Cymbalta for Fibromyalgia

Century-old vaccine gives new hope to fibromyalgia community

The fibro symptom that scares me most

10 Things to Try When You're Feeling Lonely

Inflammation Disrupts Memory - What Can You Do to Protect Your Brain?

Effects of Vitamin D Therapy on Quality of Life in Patients with Fibromyalgia.

Invisible: Interview with Filmmaker Nick Demos

Cultivating Trust to Make your NOW Better

Hypnosis for Fibromyalgia

Global Pain, Fibromyalgia and the Insula – Ground Zero for Pain and Stimuli Issues in FM?

 
Print Page
Email Article

CoQ10 supports reversal of statin-caused mitochondrial dysfunction, energy drain

  [ 19 votes ]   [ Discuss This Article ]
www.ProHealth.com • August 11, 2012


Article:
Coenzyme Q10 reverses mitochondrial dysfunction in atorvastatin-treated mice and increases exercise endurance
- Source: Journal of Applied Physiology, May 31, 2012

By A Muraki, K Miyashita, et al.

[Note: Atorvastatin, aka Lipitor, is a lipophilic statin, meaning it dissolves in & is attracted to lipids (fats). Prevastatin, aka Pravachol, is a hydrophilic statin, meaning it dissolves in water, and so is believed to have less muscle penetration than lipophilic statins.]

Abstract:
Background: Statins are cholesterol-lowering drugs widely used in the prevention of cardiovascular diseases; however, they are associated with various types of myopathies.

Statins inhibit HMG-CoA reductase and thus decrease biosynthesis of low-density lipoprotein cholesterol and may also reduce ubiquinones, essential coenzymes of a mitochondrial electron transport chain, which contain isoprenoid residues, synthesized through an HMG-CoA reductase-dependent pathway.

Therefore, we hypothesized that statin treatment might influence physical performance:

• Through muscular mitochondrial dysfunction

• Due to ubiquinone deficiency.

Methods and Results:

The effect of two statins, atorvastatin and pravastatin, on ubiquinone content, mitochondrial function and physical performance was examined by using statin-treated mice.

Changes in energy metabolism in association with statin-treatment were studied by using cultured myocytes.

We found that atorvastatin-treated mice developed:

• Muscular mitochondrial dysfunction due to ubiquinone deficiency,

• And a decrease in exercise endurance,

• Without affecting muscle mass and strength.

Meanwhile, pravastatin at 10 times higher dose [than] atorvastatin had no such effects.

In cultured myocytes, atorvastatin-related decrease in mitochondrial activity led to:

• A decrease in oxygen utilization

• And an increase in lactate production.

Conversely, coenzyme Q10 treatment in atorvastatin-treated mice:

• Reversed atorvastatin-related mitochondrial dysfunction

• And a decrease in oxygen utilization,

• And thus improved exercise endurance.

Conclusion:

Atorvastatin decreased exercise endurance in mice through mitochondrial dysfunction due to ubiquinone deficiency.

Ubiquinone supplementation with coenzyme Q10 could reverse atorvastatin-related mitochondrial dysfunction and decrease in exercise tolerance.

Source: Journal of Applied Physiology, May 31, 2012. DOI:10.1152/japplphysiol.01362 by Muraki A, Miyashita K, Mitsuishi M, Tamaki M, Tanaka K, Itoh H. Keio University School of Medicine, Minato, Tokyo, Japan. [Email: miyakaza2sc.itc.keio.ac.jp]





Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Energy NADH™ 12.5mg Hydroxocobalamin Extreme™


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
Guaifenesin FA™ Guaifenesin FA™
Helps the Body Eliminate Excess Calcium and Phosphates
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

The Genetic Mutation That May Compromise Your Health - And What to Do About It The Genetic Mutation That May Compromise Your Health - And What to Do About It
Inflammation Disrupts Memory - What Can You Do to Protect Your Brain? Inflammation Disrupts Memory - What Can You Do to Protect Your Brain?
Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask Everything You Always Wanted to Know About Sleep But Were Too Tired to Ask
Block Acid Reflux to Prevent Esophageal Problems! Block Acid Reflux to Prevent Esophageal Problems!
The Remarkable Benefits of Reishi Medicinal Mushrooms The Remarkable Benefits of Reishi Medicinal Mushrooms

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map