ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
 
Print Page
Email Article

Are ME/CFS and fibromyalgia tryptophan-associated disorders?

  [ 12 votes ]   [ 1 Comment ]
www.ProHealth.com • October 6, 2012

previous article next article

Article:
A Brief Historic Overview of Clinical Disorders Associated with Tryptophan: The Relevance to Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM)
- Source: International Journal of Tryptophan Research, Sep 17, 2012

By Adele Blankfield, BSc

[Note: The full text PDF of this article is available free HERE. It reviews research suggesting that up-regulation of the ‘kynurenine pathway’ may play a role in the clusters of signs and symptoms that predominate in ME/CFS and fibromyalgia patients.

What is the kynurenine pathway? It’s complex, but we located this brief video by biochemist Wesley Hurrell which diagrams the pathway; how its chronic up-regulation may lead to tryptophan and serotonin depletion & produce chronic Th1-immune activation; and the association with symptoms common in ME/CFS and fibromyalgia, including IBS, cognitive impairment, sleep disturbances and depression.]

Abstract:
Last century there was a short burst of interest in the tryptophan-related disorders of pellagra and related abnormalities that are usually presented in infancy.1,2 [L-Tryptophan is an essential amino acid that is a precursor to many neurotransmitters and neurochemicals, including serotonin and melotonin.]

Nutritional physiologists recognized that a severe human dietary deficiency of either tryptophan or the B group vitamins could result in central nervous system (CNS) sequelae such as ataxia [lack of muscle coordination], cognitive dysfunction and dysphoria [anxiety/restlessness], accompanied by skin hyperpigmentation.3,4

The current paper will focus on the emerging role of tryptophan in chronic fatigue syndrome (CFS) and fibromyalgia (FM).

Source: International Journal of Tryptophan Research, Sep 17, 2012; 5, 27-32. DOI: 10.4137/IJTR.S10085, by Blankfield A. Kew, Australia. [Email: gjshnier@bigpond.net.au]



previous article
  Rating 5 (12 votes) next article




DISCUSS THIS ARTICLE   (1 existing comment) Post a Comment 


Problems with tryptophan beyond kynurenine
Posted by: RolfHefti
Oct 7, 2012
The many problems related to kynurenine are just one of the problematic issues with tryptophan.

This research paper seems to insinuate that tryptophan itself isn't a problem (inferred from observed effects of an endogenous tryptophan deficiency), but primarily the chronic release of kynurenines. However, serotonin, for which tryptophan is its precursor, has been shown to be involved in numerous disease conditions, from brain degeneration, cancer, cardiovascular events, and many others (see http://www.supplements-and-health.com/tryptophan-side-effects.html). This doesn't indicate that the loading of tryptophan or serotonin, with drugs or dietary supplements, is biologically desired.
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Your Next Order

Featured Products
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Zyflamend® Whole Body by New Chapter Zyflamend® Whole Body by New Chapter
Formulated for Whole Body Healthy Inflammation Response*
Fibro Freedom™ Fibro Freedom™
Soothes, strengthens & revitalizes
Curcumin, Longvida™ by Nutrivene Curcumin, Longvida™ by Nutrivene
Helps Support Cognition, Memory & Overall Health
Vitamin D3 5000 IU Vitamin D3 5000 IU
Give your body a boost with the sunshine vitamin

Most Viewed Articles
What's the Hidden Cause Behind YOUR Fibromyalgia Flares? [more]

Pridgen Reports Fibromyalgia Antiviral Trial Results “Very Positive”: Predicts New Approach Will Be ... [more]

Massage Therapy Studies for Fibromyalgia Reviewed [more]

How to Limit or Minimize Your Fibromyalgia Flare [more]

Breaking News: FDA’s Sneak Attempt to Ban Another B Vitamin [more]

Mitochondrial Dysfunction, Post-Exertional Malaise and CFS/ME [more]

The Devil Is In The Details – A Herpes Simplex Virus Inquiry For Fibromyalgia and Chronic Fatigue Sy... [more]

FDA Says Sponsors of Chronic Fatigue Syndrome Drugs can Rely on Patient-Reported Outcomes [more]

Sensory Overload: Sources and Strategies [more]

Sympathetic Nervous System Dysfunction in FIbromyalgia and Overlapping Conditions [more]


FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing