Activate Now
ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Do You Have These Fibromyalgia Symptoms of Systemic Dysfunction?

Fibromyalgia – The Savella Story

Meet Devin Starlanyl: Fibromyalgia and Chronic Myofascial Pain Expert

Which Infection Causes CFS & Fibromyalgia?

The "Mind Diet" Reduces the Risk Of Alzheimer’s Dementia. Might It Also Help the Brain Fog Found Wit...

Need Help with Pain Management? There's an App for That

Simplifying Nutritional Support in CFS & Fibromyalgia

6 Reasons Why Trigger Point Injections Aren't Helping Your Fibromyalgia

How Multiple Chronic Illnesses Shaped One Woman Into a Patient Advocate

VIDEO: Fibromyalgia & Your Stress-Coping Savings Account

Print Page
Email Article

Combo of drugs affecting pain different ways helped central sensitization

  [ 9 votes ]   [ Discuss This Article ] • November 7, 2012

Duloxetine and Pregabalin for Pain Management in Multiple Rheumatic Diseases Associated with Fibromyalgia
– Source: Pain Practice, Nov 5, 2012 By Chiara Angeletti, MD, et al.

[Note: Duloxetine (Cymbalta) is a serotonin and norepinephrine reuptake inhibitor ('new generation' antidepressant). Pregabalin (Lyrica) is an anticonvulsant. Both are drugs that may be prescribed for fibromyalgia symptoms in the US. Their modes of action are not entirely understood but generally it is thought that duloxetine works on the nerve pathway that inhibits pain, and pregabalin acts on the parts of the nerve that conduct pain signals.]

Abstract: The fibromyalgia syndrome (FMS) is characterized by chronic and widespread musculoskeletal pain and soreness accompanied by sleep disorders, chronic fatigue and affective disorders. FMS is often associated with other forms of immuno-rheumatic diseases.

Although FMS pathophysiology is still not fully understood, a number of neuroendocrine, neurotransmission and neurosensitive disorders might generate a mechanism for the elicitation of pain by "central sensitization," which is common to many other painful conditions.

The present case describes the success of a therapeutic scheme, which associates two different pharmacological classes, anticonvulsants and new-generation antidepressants, when FMS complicates a rare pathology called Cogan's syndrome [rheumatic disease involving eye and ear inflammation].

The association of two drugs might noticeably affect the molecular mechanisms of difficult pain, thus solving painful conditions of multifactorial origin.

Source: Pain Practice (Publication of the World Institute of Pain), Nov 5, 2012. PMID:23126475. Angeletti C, Guetti C, Piroli A, Angeletti PM, Paladini A, Ciccozzi A, Marinangeli F, Varrassi G. Anesthesiology and Pain Medicine, Department of Health Sciences, University of L'Aquila, Italy. [Email:]

Please Discuss This Article:   Post a Comment 

[ Be the first to comment on this article ]

Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Subscribe Now!
Receive up-to-date ME/CFS, Fibromyalgia & Lyme Disease treatment and research news
 Privacy Guaranteed  |  View Archives

Vitamins and Supplements for Fibromyalgia Support

Featured Products

Guaifenesin FA™ Guaifenesin FA™
Natural Expectorant Relieves Chest Congestion
Fibro Freedom™ Fibro Freedom™
Soothes, strengthens & revitalizes
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen
Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed
The Surprising Benefits of Probiotics - What You Didn't Know The Surprising Benefits of Probiotics - What You Didn't Know
SAM-e: a Hard-Working Molecule that May Help Ease Pain & Brighten Mood SAM-e: a Hard-Working Molecule that May Help Ease Pain & Brighten Mood
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH

What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Causes
Fibromyalgia Treatments
Fibromyalgia Diet
Fibromyalgia Medications
M.E. & CFS
What is M.E./CFS?
M.E./CFS Diagnosis
M.E./CFS Symptoms
M.E./CFS Causes
M.E./CFS Treatments
M.E./CFS Diet
M.E./CFS Medications
What is Lyme Disease?
Lyme Disease Diagnosis
Lyme Disease Symptoms
Lyme Disease Causes
Lyme Disease Treatments
Lyme Disease Diet
Lyme Disease Medications
M.E. & CFS
Lyme Disease
General Health
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing