Activate Now
 
ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

The Legs of Fibromyalgia and Myofascial Pain

The Fatigue and Pain Hormone? Leptin Shows Up Again – in Fibromyalgia

Our Mind Wants What Our Body Can't Produce

Relief for Dry, Itchy Skin Caused by Fibromyalgia

Reversing Alzheimer’s: What Could it Mean for Chronic Fatigue Syndrome (ME/CFS) and Fibromyalgia?

VIDEO: Fibromyalgia Warnings

4 Simple Ways to Shift into Positivity

VIDEO: "I Live with Pain Everyday" (Stories of Fibromyalgia)

Recovering from Chronic Fatigue Syndrome and Fibromyalgia - The Lerner Way

Did MitoQ Mend Us? A Fibromyalgia and Chronic Fatigue Syndrome (ME/CFS) CoQ10 Trial

 
Print Page
Email Article

Melatonin Plays a Role in Reducing Pain Sensitivity

  [ 39 votes ]   [ 1 Comment ]
www.ProHealth.com • December 7, 2012


Melatonin Plays a Role in Reducing Pain SensitivityArticle:

Melatonin in antinociception: its therapeutic applications. 
– Source: Current Neuropharmacology, June 2012.

By V. Srinivasan, et al.

Abstract:

The intensity of pain sensation exhibits marked day and night variations. Since the intensity of pain perception is low during dark hours of the night when melatonin levels are high, this hormone has been implicated as one of the prime antinociceptive [reducing sensitivity to painful stimuli] substances.

A number of studies have examined the antinociceptive role of melatonin in acute, inflammatory and neuropathic pain animal models.

  • It has been demonstrated that melatonin exerts antinociceptive actions by acting at both spinal cord and supraspinal levels.

  • The mechanism of antinociceptive actions of melatonin involves opioid, benzodiazepine, a(1)- and a(2)-adrenergic, serotonergic and cholinergic receptors.

  • Most importantly however, the involvement of MT(1)/MT(2) melatonergic receptors in the spinal cord has been well documented as an antinociceptive mechanism in a number of animal models of pain perception.

  • Exogenous melatonin [melatonin produced outside the body; i.e., in supplement form] has been used effectively in the management of pain in medical conditions such as fibromyalgia, irritable bowel syndrome and migraine and cluster headache.

  • Melatonin has been tried during surgical operating conditions and has been shown to enhance both preoperative and post-operative analgesia.

The present review discusses the available evidence indicating that melatonin, acting through MT(1)/MT(2) melatonin receptors, plays an important role in the pathophysiological mechanism of pain.

Source: Current Neuropharmacology, June 2012. By V. Srinivasan, E.C. Lauterbach, K.Y. Ho, D. Acuna-Castroviejo, R. Zakaria, A. Brzezinski. Sri Sathya Sai Medical Educational and Research Foundation, Medical Sciences Research Study Center, Prasanthi Nilayam, 40 Kovai Thirunagar, Coimbatore-641014, Tamilnadu, India.

 





Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Optimized Curcumin Longvida® 5-HTP Extra Strength 200mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

Melatonin
Posted by: IanH
Dec 8, 2012
The dose of melatonin required for antinociception (painreducingg) is 10mg to 30mg. Some studies have used more than this. Any dosage lower than this has not been shown to be effective. It takes a while to get used to the slight somnolence induced by this dose.

To review this look up the Journal Of Pineal Research. Some of the papers are free to view.
Reply Reply
 
Natural Pain Relief Supplements

Featured Products

Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
5-HTP Extra Strength 200mg 5-HTP Extra Strength 200mg
Increase Serotonin Levels Naturally
Guaifenesin FA™ Guaifenesin FA™
Helps the Body Eliminate Excess Calcium and Phosphates
Fibro Freedom™ Fibro Freedom™
Soothes, Strengthens & Revitalizes

Natural Remedies

Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep? Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep?
Improve Cardiovascular and Metabolic Health with Omega-7 Improve Cardiovascular and Metabolic Health with Omega-7
Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol Red Yeast Rice - Natural Option for Supporting Healthy Cholesterol
Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map