ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|

Trending News

Novel Fibromyalgia Treatment Shows Promise in Study

7 Fibromyalgia Seasonal Stress Strategies

Drug Combo in Pridgen Antiviral Fibromyalgia Trial Identified – Some Results Available

Blunted Anti-Inflammatory Response to Exercise Increases Fibromyalgia Symptoms

Fibromyalgia Associated with Coronary Heart Disease

Happiness, Gratitude and Appreciation

Cytokine and Chemokine Profiles in Fibromyalgia, RA and Lupus: A Potentially Useful Tool in Differen...

FDA Approves Hysingla ER – Extended-Release Hydrocodone with Abuse-Deterrent Properties

5 Safety Tips for the Holidays for Persons Living with Fibromyalgia and Myofascial Pain Syndrome

Sense of Smell Impaired in Fibromyalgia Patients

 
Print Page
Email Article

Some Cases of Fibromyalgia May Actually Be Small-Fiber Polyneuropathy

  [ 32 votes ]   [ 3 Comments ]
www.ProHealth.com • June 16, 2013


Editor's comment: Small-fiber polyneuropathy involves body-wide damage to the small unmyelinated nerve fibers.  (Unmyelinated means the nerve fibers do not have a myelin sheath – the fatty substance that covers and protect nerves.)

Objective evidence that small-fiber polyneuropathy underlies some illnesses currently labeled as fibromyalgia.

Abstract:

Fibromyalgia is a common, disabling, syndrome that includes chronic widespread pain plus other diverse symptoms. No specific objective abnormalities have been identified, precluding definitive testing, disease-modifying treatments, and identification of causes.

In contrast, small-fiber polyneuropathy (SFPN), despite causing similar symptoms, is definitionally a disease caused by dysfunction and degeneration of peripheral small-fiber neurons. SFPN has established etiologies, some diagnosable and definitively treatable, e.g., diabetes.

To evaluate the hypothesis that some patients labeled with "fibromyalgia" have unrecognized SFPN causing their illness symptoms, we analyzed SFPN-associated symptoms, signs, and pathological and physiological markers in 27 fibromyalgia patients and 30 matched normal controls. Fibromyalgia subjects had to satisfy American College of Rheumatology criteria plus document actual fibromyalgia diagnoses.

Study instruments comprised the Michigan Neuropathy Screening Instrument (MNSI), the Utah Early Neuropathy Scale (UENS), distal-leg neurodiagnostic skin biopsies, plus autonomic-function testing (AFT).

  • 41% of skin biopsies from fibromyalgia subjects vs. 3% of biopsies from control subjects were diagnostic for SFPN, and

  • MNSI and UENS scores were higher among fibromyalgia than control subjects (all P ≤ 0.001).

  • Abnormal AFTs were equally prevalent suggesting that fibromyalgia-associated SFPN is primarily somatic [of or relating to the body].

  • Blood tests from all 13 fibromyalgia subjects with SFPN-diagnostic skin biopsies provided insights into etiologies.

  • All glucose tolerance tests were normal, but eight subjects had dysimmune markers, 2 had hepatitis C serologies, and one family had apparent genetic causality.

These findings suggest that some pain patients labeled with "fibromyalgia" have unrecognized small-fiber polyneuropathy, a distinct disease that can be objectively tested for and sometimes definitively treated.

Source: Pain, June 5, 2013. By Anne Louise  Oaklander, Zeva Daniela  Herzog, Heather  Downs and Max M.  Klein. Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, 02114; Department of Pathology (Neuropathology), Massachusetts General Hospital, Boston, Massachusetts, 02114.




Please Discuss This Article:   Post a Comment 

More evidence that FM is a syndrome with underlying disease
Posted by: IanH
Jun 16, 2013
Here we have 41% of this sample have sfpn. We know that around 42% of people with ME/CFS meet the criteria for FM.


Some earlier studies have shown that a significant % of people diagnosed with FM have spinal stenosis, mainly cervical myelopathy but also lumbar and even some with thoracic stenosis and vertebral compression fracture from motor accidents. Dr Dan Heffez and Alan Shephard showed this many years ago.

We are now getting close to showing that FM is a symptomatic syndrome caused by an underlying neural pathology (which sometimes has its origin in the immune interface) that needs identifying and treating.

Where is the so-called primary fibromyalgia? It does not exist!
Reply Reply

 
Dear IanH
Posted by: Helpfuljosh
Jun 11, 2014
You might find this article interesting. It is about the effects of cannabis on fybromyalgia patients. I found it quite interesting.
Cannabis-Fibromyalgia Sensi Blog

 

 
Now with link :-)
Posted by: Helpfuljosh
Jun 11, 2014
http://sensiseeds.com/en/blog/cannabis-fibromyalgia/

 

 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Nutritional Supplement Orders

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Fibro Freedom™ Fibro Freedom™
Soothes, strengthens & revitalizes
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness

Natural Remedies

"It's Not Easy Being Green" - But It Is Healthy
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
Dreaming of a Good Night's Sleep? Dreaming of a Good Night's Sleep?
The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away
Shoo Pain, Don't Bother Me - Top 10 Nutrients to Take Back Your Life Shoo Pain, Don't Bother Me - Top 10 Nutrients to Take Back Your Life

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing