ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|

Trending News

New Restrictions on Painkillers: Tramadol and Hydrocodone

Small Fiber Neuropathy Fibromyalgia Study Raises Questions

A Fibromyalgia Tale of Two Sisters

Is Venlafaxine Effective for Treating Fibromyalgia?

SURVEY: Cognitive Impairment

The Past, Present and Future of Chronic Pain Treatment

Can Online Cognitive Behavioral Therapy Help Fibromyalgia?

Disability Claims and Social Media

Increased Sensitivity in Fibromyalgia Not Due to Hypervigilance

Fibromyalgia Associated with Decreased Connectivity Between Pain-Related and Sensorimotor Areas of B...

 
Print Page
Email Article

Thermoregulation and Pain Modulation in Fibromyalgia

  [ 3 votes ]   [ 2 Comments ]
www.ProHealth.com • August 3, 2013


Review of Overlap Between Thermoregulation and Pain Modulation in Fibromyalgia.

By Alice A. Larson, PhD; José V. Pardo, MD, PhD; and Jeffrey D. Pasley, PhD

Abstract:


Fibromyalgia (FM) syndrome is characterized by widespread pain that is exacerbated by cold and stress but relieved by warmth. We review the points along thermal and pain pathways where temperature may influence pain. We also present evidence addressing the possibility that brown adipose tissue activity is linked to the pain of FM given that cold initiates thermogenesis in brown adipose tissue through adrenergic activity, whereas warmth suspends thermogenesis.

Although females have a higher incidence of FM and more resting thermogenesis, they are less able to recruit brown adipose tissue in response to chronic stress than males. In addition, conditions that are frequently comorbid with FM compromise brown adipose activity making it less responsive to sympathetic stimulation. This results in lower body temperatures, lower metabolic rates, and lower circulating cortisol/corticosterone in response to stress-characteristics of FM.

In the periphery, sympathetic nerves to brown adipose also project to surrounding tissues, including tender points characterizing FM. As a result, the musculoskeletal hyperalgesia associated with conditions such as FM may result from referred pain in the adjacent muscle and skin.

Source: The Clinical Journal of Pain, July 24, 2013. By Alice A. Larson, PhD; José V. Pardo, MD, PhD; and Jeffrey D. Pasley, PhD. Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul §Department of Physiology and Pharmacology, University of Minnesota, Duluth ‡Departments of Psychiatry, University of Minnesota †Mental Health Patient Service Line, VA Medical Center, Minneapolis, MN.




Please Discuss This Article:   Post a Comment 

Referred pain???
Posted by: IanH
Aug 3, 2013
" As a result, the musculoskeletal hyperalgesia associated with conditions such as FM may result from referred pain in the adjacent muscle and skin."

For me, I require a plausible explanation of the suggesttion of referred pain.

Many people with FM do not worsen with the cold and some people with FM are quite intolerant of higher temperatures found in the semi and tropical countries. Also we have found that some people with FM cannot tolerate thermal pools used for arthritic paliative treatments.

Overall I am doubtful of this hypothesis as a significant factor in FM.
Reply Reply

Flawed premise
Posted by: FMeditor
Aug 4, 2013
I, too, have doubts about this study. I think the premise upon which the study is based – that FM "is characterized by widespread pain that is exacerbated by cold...but relieved by warmth" – is flawed.

While most FM patients do seem to be sensitive to cold, some (like myself) feel best when it is cold and are hyper-sensitive to heat. Therefore, this hypothesis is not applicable to all FM patients.
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Fibro Freedom™ Fibro Freedom™
Soothes, strengthens & revitalizes
Guaifenesin FA™ Guaifenesin FA™
Natural Expectorant Relieves Chest Congestion
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid

Natural Remedies

Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance Front Line Defense Against Colds & Flu - Support for Healthy Immune System Balance
Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing