ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

8 Types of Fibromyalgia Pain

5 Quotes That Keep Me Strong When I Feel Like Giving Up

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery

Fibromyalgia – Does It Get Better?

Impact of pain misunderstood by public, NFCPA survey shows

Dance for Adults with Fibromyalgia – What Do We Know About It? Protocol for a Scoping Review.

VIDEO: Chronic Pain Coping Methods

Fibromyalgia expert says misdiagnosis is rampant - Part 2

Self-Reported Childhood Maltreatment and Traumatic Events among Israeli Patients Suffering from Fibr...

Fibromyalgia and Living in a Chaotic World

 
Print Page
Email Article

Increased Glutamate and Lactate Concentrations in the Trapezius Muscle and Plasma of Fibromyalgia Patients

  [ 4 votes ]   [ Discuss This Article ]
www.ProHealth.com • August 4, 2013


Chronic Widespread Pain: Increased Glutamate and Lactate Concentrations in the Trapezius Muscle and Plasma.

By Björn Gerdle, MD, PhD, et al.

Abstract:

BACKGROUND: Chronic widespread pain (CWP), including fibromyalgia syndrome (FM), is associated with prominent negative consequences. CWP has been associated with alterations in the central processing of nociception. Whereas some researchers consider CWP/FM as a central hyperexcitability pain condition, others suggest that the central alterations are maintained by peripheral nociceptive input. Microdialysis can be used in vivo to study muscle alterations in chronic myalgia.

AIM: The aim of the study was to investigate the plasma and interstitial concentrations of metabolites and algesics in the trapezius muscle of women with CWP and in pain-free women (CON).

MATERIALS AND METHODS: Seventeen women with CWP and 24 CON went through a clinical examination and completed a questionnaire; the pressure pain thresholds in the upper and lower extremities were registered. Microdialysis was conducted in the trapezius muscle, and a blood sample was drawn. Muscle blood flow, interstitial muscle concentrations, and plasma concentrations of lactate, pyruvate, glutamate, glucose, and glycerol (not in the plasma) were determined.

RESULTS:

  • CWP patients had significantly increased interstitial muscle (P=0.02 to 0.001) and plasma (P=0.026 to 0.017) concentrations of lactate and glutamate.

  • No significant differences existed in blood flow between CWP and CON.

  • The interstitial concentrations-but not the plasma levels-of glutamate and lactate correlated significantly with aspects of pain such as pressure pain thresholds of the trapezius (R=0.22) and tibialis anterior (R=0.18) and the mean pain intensity (R=0.10) in CWP but not in CON.

CONCLUSIONS: The present study supports the suggestion that aspects of pain and central alterations in CWP/FM are influenced by peripheral tissue alterations.

Source: The Clinical Journal of Pain, July 24, 2013.  By Björn Gerdle, MD, PhD; Britt Larsson, MD, PhD; Frida Forsberg, MD; Nazdar Ghafouri, MD, PhD; Linn Karlsson, RPT; Niclas Stensson, Chemist; and Bijar Ghafouri, Chemist, PhD. Rehabilitation Medicine, Department of Medicine and Health Sciences (IMH) ‡Occupational and Environmental Medicine, Department of Clinical and Experimental Medicine (IKE), Faculty of Health Sciences, University of Linköping †Pain and Rehabilitation Centre §Centre of Occupational and Environmental Medicine, UHL, County Council, Linköping, Sweden.





Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Energy NADH™ 12.5mg Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Guaifenesin FA™ Guaifenesin FA™
Helps the Body Eliminate Excess Calcium and Phosphates
Fibro Freedom™ Fibro Freedom™
Soothes, Strengthens & Revitalizes
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10
Priming Your Immune System for Cold & Flu Season Priming Your Immune System for Cold & Flu Season
Strengthen Cell Function with Energy-Boosting Niagen Strengthen Cell Function with Energy-Boosting Niagen
Top 3 Nutrients to Detox the Liver and Soothe Digestion Top 3 Nutrients to Detox the Liver and Soothe Digestion
Milk Thistle: Trusted Support for Health & Healing in a Toxic World Milk Thistle: Trusted Support for Health & Healing in a Toxic World

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map