ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|

Trending News

Fibromyalgia and Your Teeth

Could a Mitochondrial Enhancer Replace Cymbalta in Fibromyalgia?

New Study Shows Patients are Suffering Due to Hydrocodone Rescheduling

8 Fibromyalgia Diet Disaster Do Overs

Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?

Neuro-Inflammation and Chronic Pain Link Established: Authors Call for Treatment Trials

Bad Relations: Study Finds Fight or Flight Response Tied to Pain in Fibromyalgia

Successful Travel with Fibromyalgia

Acetyl L-Carnitine and Duloxetine (Cymbalta) Compared for Fibromyalgia

Fibromyalgia Characterized by Altered Gray and White Matter in Brain

 
Print Page
Email Article

Imbalance Between Oxidants and Antioxidants Found in Fibromyalgia Patients

  [ 6 votes ]   [ Discuss This Article ]
www.ProHealth.com • February 2, 2014


Is fibromyalgia-related oxidative stress implicated in the decline of physical and mental health status?

By M. La Rubia, et al.

Abstract:

OBJECTIVES: Fibromyalgia (FM) is a form of non-articular rheumatism characterised by chronic widespread musculoskeletal aching. Although some works have investigated the possible role of oxidative stress in the pathophysiology of FM, none has analysed a significant number of oxidative markers in the same patients. Consequently, we have performed an exhaustive study of the oxidative/antioxidative status in FM patients and healthy controls, as well as the relationship with FM clinical parameters.

METHODS: In 45 female patients and 25 age-matched controls, we investigated the oxidative (lipid and protein peroxidation, and oxidative DNA damage) and antioxidative status (total antioxidant capacity (TAC), and antioxidant enzyme activities and compounds). Functional capacity and musculoskeletal pain were assessed by Fibromyalgia Impact Questionnaire (FIQ) and Visual Analogue Scale (VAS), respectively. The physical (PCS-12) and mental (MCS-12) health status was evaluated by SF-12.

RESULTS:
  • A significant increase in oxidative DNA damage and protein carbonyl content was found in FM patients vs. controls, as well as in antioxidant compounds such as copper and ceruloplasmin.

  • Patients had diminished levels of TAC and zinc.

  • Enzyme activities of superoxide dismutase, glutathione peroxidase, and catalase were lower in FM patients.

  • Significant correlations were observed in patients between oxidative DNA damage and MCS-12, and zinc and PCS-12.

CONCLUSIONS: These findings reveal an imbalance between oxidants and antioxidants in FM patients. The lower antioxidant enzyme activities may lead to oxidative stress through the oxidation of DNA and proteins, which may affect the health status of FM patients.

Source: Clinical and Experimental Rheumatology, Nov-Dec 2013. By M. La Rubia, A. Rus, F. Molina and M. del Moral. Department of Experimental Biology, University of Jaén, Campus Las Lagunillas, Jaen, Spain.



Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Guaifenesin FA™ Guaifenesin FA™
Natural Expectorant Relieves Chest Congestion
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness
Fibro Freedom™ Fibro Freedom™
Soothes, strengthens & revitalizes
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health

Natural Remedies

Priming Your Immune System for Cold & Flu Season Priming Your Immune System for Cold & Flu Season
Safely Burn Away Body Fat Safely Burn Away Body Fat
Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
The Fast-Acting Solution for Healthy Digestive Function The Fast-Acting Solution for Healthy Digestive Function
Melatonin: The Brain Hormone

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing