Activate Now
 
ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Cymbalta’s Withdrawal Symptoms Prompt Lawsuits

Fibromyalgia: A Very Different Disease

Fibromyalgia: Bad; Fibromyalgia with Migraine: Really Bad

Connecting Fibromyalgia to IBS

Fibromyalgia and Sleep

4 Tips for Parenting with Chronic Illness

How Can You Be Positive When You Live With Chronic Pain?

Aching for Pain Relief?

Recovering from CFS and Fibromyalgia Series

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

 
Print Page
Email Article

Fibromyalgia Symptoms Associated with Gene Variant

  [ 13 votes ]   [ 1 Comment ]
www.ProHealth.com • April 28, 2014


Editor's comment: Catechol-O-methyltransferase is one of several enzymes involved in the degradation or inactivation of the catecholamine neurotransmitters (dopamine, epinephrine, and norepinephrine). In humans, the catechol-O-methyltransferase protein is encoded by the COMT gene. The Val158Met polymorphism is a gene variant that breaks down dopamine much faster than normal and is thought to modulate dopamine signaling in the brain's frontal lobes. This gene variant has been shown to affect cognitive tasks and may be relevant for emotional processing. The results of this study found an association between this gene variant and certain fibromyalgia symptoms.

Clinical symptoms in fibromyalgia are associated to catechol-O-methyltransferase (COMT) gene Val158Met polymorphism.

By A. Inanir, et al.

Abstract:

1.?Fibromyalgia syndrome (FMS) is a common chronic widespread pain syndrome mainly affecting women. The aim of this study was to explore the frequency and clinical significance of catechol-O-methyltransferase (COMT) gene Val158Met polymorphism in a large cohort of Turkish patients with FMS.

2.?The study included 379 FMS patients and 290 controls. Genomic DNA was isolated and genotyped using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analyses.

3.?The genotype frequencies of Val158Met polymorphism showed a small difference between FMS patients and healthy controls (p?=?0.047), however, the Met/Met genotype was significantly higher in FMS patients than healthy controls (p?=?0.016). No difference was observed for allele frequencies between two groups. Stratification analysis according to clinical features for this disease reveals that weight, FMS Impact Questionnaire score, algometry and Raynaud's syndrome, were detected to have statistically significant associations with Val158Met polymorphism (p?=?0.037, p?=?0.042, p?=?0.039 and p?=?0.033, respectively). Pain sensitivity, measured by algometry, was statistically higher in patients with Met/Met genotype than the patients with Val/Val and Val/Met genotypes (p?=?0.017).

4.?The results of this study suggested that COMT gene Val158Met polymorphism is positively associated with FMS and play a relevant role in the clinical symptoms of the disease.

Source: Xenobiotica, April 24, 2014. By A. Inanir, N. Karakus, O. Ates, S. Sezer, N. Bozkurt, S. Inanir and S. Yigit. Department of Physical Therapy and Rehabilitation, Faculty of Medicine.




Post a Comment

Featured Products From the ProHealth Store
Fibro Freedom™ FibroSleep™ Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments Post a Comment

Gene Variant
Posted by: elvis321
Apr 29, 2014
I do find this study interesting, and wonder if??? there is anything to indicate Frontal Lobe dysfunction may also be due to birth trauma ie: lack of oxygen, resuscitation post birth etc that causes a brain injury. Is is strictly the gene? There is trending of this in children with ADHD. I'm thinking there is a correlation.
I guess I'd also like to know...what's this now going to do for those of us already diagnosed? O.K. if you now know a cause...but what makes it different, can be done? Still nothing.
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS, Fibromyalgia & Lyme Disease treatment and research news
 Privacy Guaranteed  |  View Archives

How Glutathione Can Save Your Life

Featured Products

B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Fibro Freedom™ Fibro Freedom™
Soothes, strengthens & revitalizes
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 your brain needs for detox & sharpness

Natural Remedies

Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel Irritable Bowel Syndrome: Unlocking the Secrets of Peppermint, Acacia and Fennel
Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera Soothe, Heal and Regulate Your Digestive System with Nutrient-Rich Aloe Vera
Coping When Colds or Flu Catch Up with You Coping When Colds or Flu Catch Up with You
Guarding Against the Dangers of Vitamin D Deficiency Guarding Against the Dangers of Vitamin D Deficiency
IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders

FIBROMYALGIA
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Causes
Fibromyalgia Treatments
Fibromyalgia Diet
Fibromyalgia Medications
M.E. & CFS
What is M.E./CFS?
M.E./CFS Diagnosis
M.E./CFS Symptoms
M.E./CFS Causes
M.E./CFS Treatments
M.E./CFS Diet
M.E./CFS Medications
LYME DISEASE
What is Lyme Disease?
Lyme Disease Diagnosis
Lyme Disease Symptoms
Lyme Disease Causes
Lyme Disease Treatments
Lyme Disease Diet
Lyme Disease Medications
FORUMS
Fibromyalgia
M.E. & CFS
Lyme Disease
General Health
WHOLESALE
AFFILIATES GUARANTEE
PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing