ProHealth fibromyalgia Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Orthostatic Intolerance, Part 1: Diagnosing OI

Yes, It Really Is Possible to Restore Mitochondrial Function!

Can Pomegranates Slow Aging?

Pitfalls and Pleasures of Therapeutic Massage for Fibromyalgia and Myofascial Pain

On Being Thankful for My Spouse as a Chronic Illness Sufferer

Is Searching for THE Answer Making You Worse?

The Cure for Giving Up (When it Feels Like Chronic Pain Is Forever)

Orthostatic Intolerance, Part 2: Treating OI

Qigong and Fibromyalgia 

Changing the public narrative about chronic pain as a disease

 
Print Page
Email Article

A Brief Review of the Pharmacology of Amitriptyline and Clinical Outcomes in Treating Fibromyalgia.

  [ 5 votes ]   [ 2 Comments ]
By Lawson K. • www.ProHealth.com • June 20, 2017


ABSTRACT

Fibromyalgia is a complex chronic condition characterized by pain, physical fatigue, sleep disorder and cognitive impairment. Evidence-based guidelines recommend antidepressants as treatments of fibromyalgia where tricyclics are often considered to have the greatest efficacy, with amitriptyline often being a first-line treatment.
 
Amitriptyline evokes a preferential reduction in pain and fatigue of fibromyalgia, and in the Fibromyalgia Impact Questionnaire (FIQ) score, which is a quality of life assessment. The multimodal profile of the mechanisms of action of amitriptyline include monoamine reuptake inhibition, receptor modulation and ion channel modulation. Several of the actions of amitriptyline on multiple nociceptive and sensory processes at central and peripheral locations have the potential to act cumulatively to suppress the characteristic symptoms of fibromyalgia.
 
Greater understanding of the role of these mechanisms of action of amitriptyline could provide further clues to the pathophysiology of fibromyalgia and to a preferable pharmacological profile for future drug development.

Full text available here.
 
Lawson K. A Brief Review of the Pharmacology of Amitriptyline and Clinical Outcomes in Treating Fibromyalgia. Biomedicines. 2017 May 17;5(2). pii: E24. doi: 10.3390/biomedicines5020024.




Post a Comment

Featured Products From the ProHealth Store
Fibro Freedom™ FibroSleep™ B-12 Extreme™


Article Comments Post a Comment

Amitriptyline
Posted by: IanH
Jun 20, 2017
Bear in mind that amitriptyline has poor efficacy in FM. So investigating the pharmacology of the drug within FM seems quite pointless. Amitriptyline has so many effects. It is not any more effective than cylcobenzaprine or orphenadrine. Cannabinadiol is more effective so why not study the pharmacology of that.
Reply Reply

Amitriptyline
Posted by: SharonG.
Jun 27, 2017
Amitriptyline has one of the longest lists of side effects there is. NOT a good choice.
Reply Reply
 
Optimized Curcumin Longvida with Omega-3

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
B-12 Extreme™ B-12 Extreme™
The Most Potent Vitamin B-12 on Earth
Fibro Freedom™ Fibro Freedom™
Soothes, Strengthens & Revitalizes
Guaifenesin FA™ Guaifenesin FA™
Helps the Body Eliminate Excess Calcium and Phosphates
Hydroxocobalamin Extreme™ Hydroxocobalamin Extreme™
The B-12 Your Brain Needs for Detox & Sharpness

Natural Remedies

Curcumin - a Golden Gift of Nature with Benefits Still Untold Curcumin - a Golden Gift of Nature with Benefits Still Untold
Complete and Natural Menopause Relief Complete and Natural Menopause Relief
More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History
Block food Cravings At Their Molecular Root Block food Cravings At Their Molecular Root
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map