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Type |
Title |
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May 12, 2008 |
Abstract |
S-Adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: A double-blind cross-over trial [ISRCTN36233495] – Source: BMC Musculoskeletal Disorders, Feb 2004
The dietary supplement SAMe had a slower onset of action but supported improved comfort in knee osteoarthritis patients as effectively as the prescription drug celecoxib (brand name CelebrexR). [Source: BMC Musculoskeletal Disorders, Feb 2004] |
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May 07, 2008 |
Abstract |
Double-blind Placebo-Controlled Trial of Amitriptyline for the Treatment of Irritable Bowel Syndrome in Adolescents – Source: Journal of Pediatrics, May 2008
Though this drug comes with a black box warning for adolescents when used for depression, this small UCLA trial indicates a lower dose (already used in adult IBS treatment) offers promise for improved quality of life in adolescents with IBS. Long-term follow-up and investigation of alternatives is planned. [Source: Journal of Pediatrics, May 2008] |
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May 07, 2008 |
Article |
Antidepressant found to alleviate symptoms of Irritable Bowel Syndrome in adolescents
UCLA trial reports small doses of the tricyclic antidepressant amitriptyline (shown to be effective for adults with IBS) significantly improved pain & quality of life for adolescents with IBS. |
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May 06, 2008 |
Chat |
Letters From Our Readers - Comments & Suggestions 05-07-08
Letters From Our Readers - Comments & Suggestions 05-07-08 |
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May 05, 2008 |
Abstract |
Macrophage-Derived Proinflammatory Factors Contribute to the Development of Arthritis and Myositis after Infection with an Arthrogenic Alphavirus - Source: The Journal of Infectious Diseases, Apr 23, 2008
Study demonstrates that macrophage-derived factors play an important role in the arthritic inflammation and tissue damage following infection with insect-borne alphaviruses such as Ross River virus - and that the sulfa drug sulfasalzine neutralizes the effect. [Source: The Journal of Infectious Diseases, April 23, 2008] |
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May 02, 2008 |
Article |
International Study of Drug to Control Osteoarthritis Progression Recruiting Now
71 centers in 10 countries & Canadian provinces are now recruiting female subjects with knee osteoarthritis, also known as ‘degenerative joint disease,’ for a 2-year Phase II study (target enrollment 1,400). |
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May 02, 2008 |
Abstract |
Treatment of osteoarthritis with PycnogenolR. The SVOS (San Valentino Osteo-arthrosis Study): Evaluation of signs, symptoms, physical performance and vascular aspects – Source: Phytotherapy Research, Apr 2008
Osteoarthritis study reports supplementation with antioxidant bark extract may support symptom improvement & analgesic use reduction.[Source: Phytotherapy Research, Apr 2008] |
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May 01, 2008 |
Abstract |
Arthritis develops but fails to resolve during inhibition of cyclooxygenase 2 [COX-2] in a murine model of Lyme disease – Source: Arthritis and Rheumatism, Apr 25, 2008
COX-2 is an enzyme responsible for inflammation and pain. COX-2 inhibitor products include non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin or ibuprofen. This animal study suggests COX-2 inhibitors may also inhibit inflammation-resolving ‘signaling molecules’ made by oxygenation of the omega-3 fatty acid found in fish oil. [Source: Arthritis and Rheumatism, Apr 25, 2008] |
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May 01, 2008 |
Abstract |
Low-dose hydrocortisone [cortisol] in the evening modulates symptom severity in Restless Legs Syndrome – Source: Neurology, Apr 2008
Study finds probable physiologic relationship between evening and early night hour restless legs syndrome symptom increase and low cortisol level - and reduction of symptoms with hydrocortisone treatment. (Levels of cortisol, called the “stress hormone” are typically cyclical - higher in early morning hours and lowest at night.) [Source: Neurology, Apr 2008] |
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Apr 29, 2008 |
Abstract |
Cod liver oil (omega-3 fatty acids) as an non-steroidal anti-inflammatory drug sparing agent in rheumatoid arthritis – Source: Rheumatology, May 2008
39% of RA patients taking fish oil cut their need for NSAID pain relievers (such as ibuprofen, aspirin) by more than one-third while also reducing pain scores. These pain relievers are associated with gastrointestinal and cardiovascular side effects. Free full text available online. [Source: Rheumatology, May 2008] |
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