ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Higher dementia risk linked to more use of common drugs

Top Anti-Inflammatory Foods, Herbs, and Spices

Latent HIV may lurk in 'quiet' immune cells, research suggests

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

Propolis - The Natural Antibiotic for MRSA, Candida, and More

Multiple sclerosis: pathological progression of the disease documented for the first time

Activate Your Natural Killer Cells

Microbiome linked to type 1 diabetes

Baylor Scientist Finds First Direct Evidence of Gene-Exposure Link in Gulf War Illness

Lyme disease costs up to $1. 3 billion per year to treat, study finds

 
Print Page
Email Article

Resveratrol Increases Vascular Oxidative Stress Resistance

  [ 238 votes ]   [ Discuss This Article ]
By ZI Ungvari, et al • www.ProHealth.com • February 14, 2007


Journal: American Journal of Physiology Heart and Circulatory Physiology. 2007. Jan 12 [E-publication ahead of print] Authors and affiliation: Ungvari ZI, Orosz Z, Rivera A, Labinskyy N, Xiangmin Z, Olson SC, Podlutsky A, Csiszar A. Physiology, New York Medical College, Valhalla, New York, USA. PMID: 17220179 Epidemiological studies suggest that Mediterranean diets rich in resveratrol are associated with reduced risk of coronary artery disease. [Resveratrol is obtained for example from grapes/wine, as well as berries such as cranberries and blueberries, and peanuts.] However, the mechanisms by which resveratrol exerts its vasculoprotective effects are not completely understood. Because oxidative stress and endothelial cell injury play a critical role in vascular aging and atherogenesis, we evaluated whether resveratrol inhibits oxidative stress-induced endothelial apoptosis.[Endothelial cells line the entire circulatory system, from the heart to the smallest capillary. Apoptosis is the process of cell death.] We found that oxidized LDL (ox-LDL) and TNFalpha elicited significant increases in caspase 3/7 activity in cultured endothelial cells, which were prevented by resveratrol pre-treatment (10(-6) to 10(-4) mol/). The protective effect of resveratrol was partially reversed by glutathione peroxidase inhibitor mercaptosuccinate, suggesting a role for antioxidant systems in the anti-apoptotic action of resveratrol. Indeed, resveratrol treatment protected cultured aortic segments and/or endothelial cells against increases in intracellular H2O2 levels and H2O2-mediated apoptotic cell death induced by oxidative stressors (exogenous H2O2, paraquat, ultraviolet light). Resveratrol treatment up-regulated the expression of glutathione peroxidase and catalase in cultured arteries, whereas it had no significant effect on expression of SOD isoforms. Resveratrol also effectively scavenged H2O2 in vitro. Thus, resveratrol seems to increase vascular oxidative stress resistance by scavenging H2O2 and preventing oxidative stress-induced endothelial cell death. We propose that the anti-oxidant and anti-apoptotic effects of resveratrol, together with its previously described anti-inflammatory actions, are responsible, at least in part, for its cardioprotective effects. Keywords: oxidative stress, endothelial cell, resveratrol, comet assay, caloric restriction mimetics.



Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away
Protect Against Sun-Induced Skin Aging From The Inside Out Protect Against Sun-Induced Skin Aging From The Inside Out
The Curcumin Revolution: The Curcumin Revolution: "Golden" Ticket to Better Health
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing