ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Delayed diagnosis of Lyme disease has devastating effect on patients

Missing Link Found Between Brain, Immune System - Major Disease Implications

Association of lyme disease and schizoaffective disorder, bipolar type: Is it inflammation mediated?

Adapt to Stress Naturally with These Power Herbs

Curcumin Made 65X More Bioavailable - Modern Take on a "Golden" Spice Busts Brain Fog, Joint & Body ...

Why So Many Arthritis Sufferers Fail to Find Relief

Discovering Coffee's Unique Health Benefits

Safely Manage Joint Inflammation: Curcumin

Bay Area Lyme Foundation Awards Grant to Harvard Medical School Researchers for Development of an Ac...

Therapeutic program reverses cognitive decline

 
Print Page
Email Article

Genetic evaluation of the serotonergic system in Chronic Fatigue Syndrome – Source: Psychoneuroendocrinology, Dec 11, 2007

  [ 69 votes ]   [ Discuss This Article ]
By AK Smith, et al. • www.ProHealth.com • December 15, 2007


Chronic Fatigue Syndrome (CFS) is a debilitating disorder of unknown etiology with no known lesions, diagnostic markers or therapeutic intervention. The pathophysiology of CFS remains elusive, although abnormalities in the central nervous system (CNS) have been implicated, particularly hyperactivity of the serotonergic (5-hydroxytryptamine; 5-HT) system and hypoactivity of the hypothalamic-pituitary-adrenal (HPA) axis.

Since alterations in 5-HT signaling can lead to physiologic and behavioral changes, a genetic evaluation of the 5-HT system was undertaken to identify serotonergic markers associated with CFS and potential mechanisms for CNS abnormality.

A total of 77 polymorphisms in genes related to serotonin synthesis (TPH2), signaling (HTR1A, HTR1E, HTR2A, HTR2B, HTR2C, HTR3A, HTR3B, HTR4, HTR5A, HTR6, and HTR7), transport (SLC6A4), and catabolism (MAOA) were examined in 137 clinically evaluated subjects (40 CFS, 55 with insufficient fatigue, and 42 non-fatigued, NF, controls) derived from a population-based CFS surveillance study in Wichita, Kansas.

  • Of the polymorphisms examined, three markers (-1438G/A, C102T, and rs1923884), all located in the 5-HT receptor subtype HTR2A, were associated with CFS when compared to NF controls.
  • Additionally, consistent associations were observed between HTR2A variants and quantitative measures of disability and fatigue in all subjects.
  • The most compelling of these associations was with the A allele of -1438G/A (rs6311) which is suggested to have increased promoter activity in functional studies.
  • Further, in silico analysis revealed that the -1438 A allele creates a consensus binding site for Th1/E47, a transcription factor implicated in the development of the nervous system. Electrophoretic mobility shift assay supports allele-specific binding of E47 to the A allele but not the G allele at this locus.
  • These data indicate that sequence variation in HTR2A, potentially resulting in its enhanced activity, may be involved in the pathophysiology of CFS.

    Source: Psychoneuroendocrinology. Dec 11 2007 [E-pub ahead of print] PMID: 18079067, by Smith AK, Dimulescu I, Falkenberg VR, Narasimhan S, Heim C, Vernon SD, Rajeevan MS. Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.




    Please Discuss This Article:   Post a Comment 



    [ Be the first to comment on this article ]




     
    Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
    Subscribe to
    Our FREE
    Newsletter
    Subscribe Now!
    Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
     Privacy Guaranteed  |  View Archives

    Save on Vitamins and Supplements

    Featured Products

    Energy NADH™ 12.5mg Energy NADH™ 12.5mg
    Improve Energy & Cognitive Function
    FibroSleep™ FibroSleep™
    The All-in-One Natural Sleep Aid
    Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
    Reduce Fatigue up to 45%
    Vitamin D3 Extreme™ Vitamin D3 Extreme™
    50,000 IU Vitamin D3 - Prescription Strength
    Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
    Ultra concentrated source of essential fish oils

    Natural Remedies

    Prepare Yourself for Cold & Flu Season
    The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
    Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle
    Help for Soreness and Swelling: What Do Silkworms Have to Do With It? Help for Soreness and Swelling: What Do Silkworms Have to Do With It?
    More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History

    FIBROMYALGIA RESOURCES
    What is Fibromyalgia?
    Fibromyalgia Diagnosis
    Fibromyalgia Symptoms
    Fibromyalgia Treatments
    | CFS RESOURCES
    What is CFS?
    ME/CFS Diagnosis
    ME/CFS Symptoms
    ME/CFS Treatments
    | FORUMS
    Fibromyalgia
    ME/CFS
    ADVANCED MEDICAL LABS
    WHOLESALE  |  AFFILIATES
    GUARANTEE  |  PRIVACY
    CONTACT US
    LIBRARY
    RSS
    SITE MAP
    ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
    Credit Card Processing