Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

How One LLND Treats Lyme disease and Co-infections Using Natural Medicine

12 Celebrities with Lyme Disease

Single Low-magnitude Electric Pulse Successfully Fights Inflammation

Sexual Transmission of Lyme Disease: a Paradigm Shift

Why Is Spicy Food Good for You?

Omega-3 fatty acids may help improve treatment, quality of life in cancer patients

Parasites and Worms As Major Complicating Co-Factors In Lyme Disease Recovery

How Essential Oils Can Help Improve Your Life

Ask the Doctor- Is it possible to be fully healed from or cured of Lyme Disease?

Anti-histamine drug Claritin can kill Borrelia by interfering with manganese utilization

 
Print Page
Email Article

Altered intestinal permeability in patients with primary Fibromyalgia and in patients with complex regional pain syndrome – Source: Rheumatology (Oxford), June 7, 2008

  [ 55 votes ]   [ 2 Comments ]
By A Goebel, et al. • www.ProHealth.com • June 20, 2008


[Note: Intestinal permeability – “leaky gut” – is when irritation or damage of the intestinal lining, as from bacterial overgrowth, causes loosening of junctions between the cells, allowing the escape of molecules that would not normally be allowed to pass through to the bloodstream (pathogens, undigested food, toxins) and triggering an immune system response that can cause inflammation in the body. Dr. Kenny De Meirleir's recent reports, for example, point to problems with the intestinal lining in the majority of ME/CFS patients he sees.]

Objectives: The pain intensity of patients with FM has recently been reported to be correlated with the degree of small intestinal bacterial overgrowth (SIBO). SIBO is often associated with an increased intestinal permeability (IP). Increased IP, if shown in FM, may have pathogenetic relevance because it leads to the exposure of immune cells to luminal antigens and consequent immune modulation.

It is currently unknown whether IP is altered in FM. We therefore examined the IP in a group of patients with primary FM and in two control groups - healthy volunteers and patients with an unrelated chronic pain syndrome, complex regional pain syndrome (CRPS).

We hypothesized that patients with FM, but not volunteers or those patients with CRPS, would have altered IP.

Methods: Both gastroduodenal and small IP were assessed using an established three-sugar test, where urinary disaccharide excretion reflecting intestinal uptake was measured using HPLC.

Results: Forty patients with primary FM, 57 age- and sex-matched volunteers and 17 patients with CRPS were enrolled in this study.

  • In the FM group, 13 patients had raised gastroduodenal permeability and 15 patients had raised small intestinal permeability,
  • But only 1 volunteer had increased gastroduodenal permeability (P < 0.0001, chi-square test for the three groups).
  • The IP values were significantly increased in the patient groups (P < 0.0003 for all comparisons, one-way analysis of variance).

Conclusions: The IPs in primary FM and, unexpectedly, CRPS are increased.

This study should stimulate further research to determine the implication of altered IP in the disease pathophysiology of FM and CRPS.

Source: Rheumatology (Oxford). June 7, 2008. [Epub ahead of print] PMID: 18540025, by Goebel A, Buhner S, Schedel R, Lochs H, Sprotte G. Pain Management Centre, University Hospital Wuerzburg, Wuerzburg; Department for Gastroenterology, Hepatology and Endocrinology, Charite Universitatsmedizin, Berlin, Germany. [E-mail: andreasgoebel@rocketmail.com]




Please Discuss This Article:   Post a Comment 

stoumach aches and cervical disc problems
Posted by: annavirgil
Jun 25, 2008
I HAVE FIBROMYALGIA AND SUFFERED TERRIBLY FROM WHAT I THOUGHT WERE STRESS STOUMACH ACHES WHEN I WAS YOUNG. I HAVE HAD SURGERY ON MY CERVICAL DISC AND ALSO THE REST OF MY SPINE. I AM ALSO DIABETIC. I WONDER HOW MANY OTHER PEOPLE OUT THERE WITH FIBROMYALGIA HAVE THESE THINGS GOING ON ALSO. I WAS UNDER TREMENDOUS STRESS WHEN I GOT THE DIAGNOSIS OF FIBROMYALGIA AND SHORTLY THEREAFTER HAD DIABETES AND STARTED HAVING DISC PROBLEMS WITH DEGENERATIVE DISC DISEASE. I HAVE ALWAYS THOUGHT THESE WERE ALL RELATED. MY STRESS LEVELS WERE HIGH WHEN I GOT OLDER WITH THE FIBRO, DISC DISEASE, DIABETES AND "NERVOUS STOUMACH" WHEN ATTEMPTING WHAT I PERCEIVED AS A STRESSFUL SITUATION FOR ME. ANYBODY ELSE OUT THERE HAVE THE SAME PROBLEMS OR SOME COMBINATION OF THESE PROBLEMS? IT DOESNT SURPRISE ME THAT THEY MIGHT BE RELATED TO STOUMACH PROBLEMS.
Reply Reply

 
I have the same problems
Posted by: prazethelord
Jun 25, 2008
I have FM and degenterative disk disease and problems with acid reflux and IBS. I don't need to have any stress to bother mine illnesses they flare up all the time. I do not have diabetes but I am hypoglycemic. Everyone is different.

 

 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Nutritional Supplement Orders

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Breaking Through the Mental Fog Breaking Through the Mental Fog
Complete and Natural Menopause Relief Complete and Natural Menopause Relief
Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
Vitamin E: Super Antioxidant We Only Thought We Knew Vitamin E: Super Antioxidant We Only Thought We Knew
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing