Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Patient Insights into the Design of Technology to Support a Strengths-Based Approach to Health Care.

Greater intake of dietary omega-3 fatty acids associated with lower risk of diabetic retinopathy

SURVEY: Weight Management & Chronic Illness

Japanese green tea consumers have reduced risk of dementia

Do Nothing, Accomplish Everything! The Connection Between Breathing and Healing

Nature Heals

Best Herbs to Help With Insomnia

Meet the ProHealth Editors

Choline: Why You Should Eat Your Egg Yolks and Take Krill

Calcium, vitamin D supplementation associated improved stroke recovery

 
Print Page
Email Article

Dr. St. Amand Comments on First Report from City of Hope Fibromyalgia Research

  [ 167 votes ]   [ Discuss This Article ]
By R. Paul St. Amand, MD • www.ProHealth.com • June 23, 2008


Subject: “High plasma levels of MCP-1 and eotaxin provide evidence for an immunological basis of fibromyalgia”* - the first publication of a three-year investigation involving patients of Fibromyalgia specialist R. Paul St. Amand, MD,** and City of Hope (an “Immunological and Genetic Analysis of Autoinflammatory Genes in Fibromyalgia.”)

__________

June 5, 2008 - A report of the research study from the City of Hope (Duarte, California) described new findings in some of our patients with fibromyalgia.

This very technical paper can be read on line (http://www.ebmonline.org/cgi/content/abstract/0712-RM-328v1), but I will try to simplify it. My summary will omit some fascinating and pertinent material in its simplification.

The function of our genes is to dictate the formation of proteins throughout the body. You know these proteins as enzymes, hormones, antibodies, components of cell structures and so on. Our study examined twenty-five circulating proteins known as cytokines or chemokines. We found that several were abnormally elevated in the blood of FM patients as well as in some of their family members (with and without fibromyalgia) when compared with normal controls.

Two proteins were most prominently elevated. They are known as

  • Eotaxin
  • And MCP-1 (monocyte chemotactic protein-1).

When tested in tandem, the elevations correctly identified fibromyalgia in up to 50% of the patients.

But when two other less-prominently abnormal cytokines (four total) were factored into the testing, the diagnostic probability rose to somewhere between 70% - 80%.

These two additional cytokines are TNF-alpha and IFN-gamma (tumor necrosis factor alpha and Interferon-gamma).

Interestingly, eotaxin was even higher in patients treated with guaifenesin. MCP-1, on the other hand, showed the same elevated levels in treated or untreated fibromyalgics. The other two cytokines actually dropped down to normal in patients treated with guaifenesin.

Obviously, this raises the question of whether more eotaxin is needed by fibromyalgics to protect them from something else - such as inflammatory effects of other cytokines. It certainly reflects that guaifenesin has distinct effects on cytokines that have been previously unknown.

This is a very technical research paper that addressed only laboratory findings. It does not describe the feasibility of testing cytokines by an average clinical laboratory. However, the study is ongoing and will certainly produce more data and hone in on what could become mainstream testing for fibromyalgia. Such facts will surely become more relevant as results from the current genetic arm of the study are published. Genetic findings point the way for future biochemical analyses, and this paper did reinforce our stance that the disease is inherited in the vast majority of patients.

Obviously, we are closer to a solution for the complicated aberrant biochemistry and physiology that so thoroughly disrupts the life of fibromyalgics and their families. As Churchill would say, "This is not the end, but it is the beginning of the beginning." It gives credence to our protocol even though its benefits to patients were not part of this project.

_____
* “High plasma levels of MCP-1 and eotaxin provide evidence for an immunological basis of fibromyalgia,” Experimental Biology and Medicine (Maywood). Jun 5, 2008. PMID: 18535166, by Zhang Z, Cherryholmes G, Mao A, Marek C, Longmate J, Kalos M, St Amand RP, Shively JE. City of Hope. ** Dr. St. Amand directs the Fibromyalgia Treatment Center in Marina Del Rey, CA, where he and his Medical Assistant/co-author Claudia Marek – themselves both fibromyalgics - see patients from all over the world. Dr. St. Amand is Assistant Clinical Professor of Medicine-Endocrinology at Harbor-UCLA Medical Center, and is known as developer of the “Guaifenesin Protocol.” To read much more about Dr. St. Amand’s FM treatment philosophy, protocol, and publications, see “Q&A Session with R. Paul St. Amand, MD.”

Note: This information has not been evaluated by the FDA. It is generic and is not meant to prevent, diagnose, mitigate, treat, or cure any illness, condition, or disease. It is very important that you make no change in your healthcare plan or health support regimen without researching and discussing it in collaboration with your professional healthcare team.




Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg FibroSleep™ Ultra ATP+, Double Strength

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Improve Cardiovascular and Metabolic Health with Omega-7 Improve Cardiovascular and Metabolic Health with Omega-7
The New Dual Activation Pain Relief Cream The New Dual Activation Pain Relief Cream
The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol
Quercetin: Natural Support for Allergy & Inflammation Relief and More Quercetin: Natural Support for Allergy & Inflammation Relief and More
More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map