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No consistent difference in gray matter volume between individuals with fibromyalgia and age-matched healthy subjects when controlling for affective disorder - Source: Pain, Apr 15, 2009

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By MC Hsu, DJ Clauw, et al. • • April 21, 2009

[Note: affective disorder is defined as a consistent, pervasive alteration in mood such as depression.]

Fibromyalgia (FM) is thought to involve abnormalities in central pain processing. Recent studies involving small samples have suggested alterations in gray matter volume (GMV) in brains of FM patients. Our objective was to verify these findings in a somewhat larger sample using voxel-based morphometry (VBM), while controlling for the presence of affective disorders (AD).

T1-weighted magnetic resonance image (MRI) brain scans were obtained on:

• 29 FM patients with AD,

• 29 FM patients without AD,

• And 29 age-matched healthy controls (HCs) using a 3T scanner.

Segmentation, spatial normalization, and volumetric modulation were performed using an automated protocol within SPM5. Smoothed gray matter segments were entered into a voxel-wise one-way ANOVA, and a search for significant clusters was performed using thresholding methods published in previous studies (whole-brain threshold of p<.05 correcting for multiple comparisons; region-of-interest (ROI) threshold of p.001 uncorrected, or p<.05 small-volume corrected).

• The whole-brain analysis did not reveal any significant clusters.

• ROI-based analysis revealed a significant difference in left anterior insula GMV among the three groups (xyz={-28, 21, 9}; p=.026, corrected).

• However, on post-hoc testing, FM patients without affective disorder did not differ significantly from healthy controls with respect to mean GMV extracted from this cluster.

• A significant negative correlation was found between mean cluster GMV and scores of trait anxiety (State-Trait Personality Inventory, Trait Anxiety scale; rho=-.470, p<.001).

• No other significant clusters were found on ROI-based analysis.

Our results emphasize the importance of correcting for AD when carrying out VBM studies in chronic pain.

Source: Pain, Apr 15, 2009. PMID: 19375224, by Hsu MC, Harris RE, Sundgren PC, Welsh RC, Fernandes CR, Clauw DJ, Williams DA. Department of Physical Medicine & Rehabilitation, University of Michigan Chronic Pain & Fatigue Research Center, Ann Arbor, Michigan, USA. [E-mail:]

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