ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Gut Bacteria, Artificial Sweeteners and Glucose Intolerance

Reverse Mitochondrial Damage

Culprits of Autism Identified: Toxins, Gut Bacteria, Nutritional Deficiencies, and Vaccines Made wit...

Turmeric compound boosts regeneration of brain stem cells

Lower risk of mortality over thirteen year period in association with higher levels of vitamin D

Use of Broad-Spectrum Antibiotics Before Age 2 Associated with Obesity Risk

CoQ10: The Longevity Factor

Is Homocysteine Making You Sick?

VIDEO: Beautiful Clouds - Relaxation and Meditation

Magnesium: Widespread Deficiency with Deadly Consequences

 
Print Page
Email Article

Fish Oil DHA within 5 Hours After Stroke May Limit & Even Repair Some Brain Damage – LSU Research Discovery

  [ 14 votes ]   [ Discuss This Article ]
www.ProHealth.com • November 8, 2010


In these animal trials, “Not only did DHA treatment salvage brain tissue that would have died, its repair mechanisms rendered some areas indistinguishable from normal tissue by 7 days.”

Research led by Dr. Nicolas Bazan, MD, PhD, at Louisiana State University has shown that a component of fish oil - Docosahexaenoic acid (DHA) -  is a powerful therapeutic agent that can protect brain tissue and promote recovery in an experimental model of acute ischemic (blockage-caused) stroke, even when treatment is delayed by up to five hours.

These findings not only target a new stroke treatment approach, but also provide vital information about the length of the therapeutic window.

The NIH-funded research was published Nov 8 by the journal Translational Stroke Research. [See the open access article: “Docosahexaenoic Acid Therapy of Experimental Ischemic Stroke.”]

Ischemic strokes result from loss of blood flow to an area of the brain due to a blockage such as a clot or atherosclerosis.

• The damage includes an irreversibly injured core of tissue at the site of the blockage.

• The area of tissue surrounding the core, called the penumbra, is also damaged but potentially salvageable.

• The penumbra has a limited life span and appears to undergo irreversible damage within a few hours unless blood flow is reestablished and neuroprotective therapy is administered. (A cascade of chemicals floods the tissue along with restored blood flow, including damaging free radicals and pro-inflammatory enzymes which can cause further damage and cell death.)

The DHA in fish oil is an essential omega-3-fatty acid and is vital for proper brain function. It is also necessary for the development of the nervous system, including vision. Moreover, omega-3 fatty acids, found in cold water fatty fish, including salmon, tuna, mackerel, sardines, shellfish, and herring, are part of a healthy diet that helps lower the risk of heart disease. [DHA is also found in krill & algae oils, which is where the fish get it.]

DHA has potent anti-inflammatory effects. Since inflammation is at the root of many chronic diseases, DHA treatment has been widely demonstrated to have beneficial effects in patients with coronary heart disease, asthma, rheumatoid arthritis, osteoporosis, sepsis, cancer, dry eye disease, and age-related macular degeneration, but its potential benefit in stroke was not known.

"We are just now beginning to understand the significant impact of omega-3 essential fatty acids on stroke," notes Dr. Bazan. "There is no simple solution just yet, but each new discovery brings us closer to defeating stroke and other debilitating neurodegenerative diseases."

To determine how DHA might be effective in stroke treatment and recovery, the LSUHSC research team administered either DHA or saline intravenously at 3, 4, 5, and 6 hours after the onset of stroke.

• MRIs showed that neurological deficits were reduced by the administration of DHA.

• DHA treatment reduced swelling and facilitated neurobehavioral recovery.

• The volume of the area of destroyed tissue was reduced by an average of 40% when DHA was administered at 3 hours, 66% at 4 hours, and 59% at 5 hours.

• Further analysis showed it triggered production of Neuroprotectin D1 (NPD1), a naturally occurring neuroprotective molecule in the brain derived from DHA and discovered by Dr. Bazan.

• Not only did DHA treatment salvage brain tissue that would have died, its repair mechanisms rendered some areas indistinguishable from normal tissue by 7 days. Dr. Bazan's laboratory leads the field of medical research into understanding DHA's and NPD1's pro-survival properties.

Administering clot-busting drugs (thrombolysis) is currently the only treatment for ischemic stroke. But due to a narrow therapeutic window and complexity of administration, only 30% of patients benefit from thrombolysis.

According to the World Health Organization, 15 million people worldwide have a stroke each year, 6 million of whom die from it. Stroke is the second leading cause of death for people above the age of 60 and is the leading cause of long-term disability irrespective of age, gender, ethnicity or country. Louisiana ranks 46th in stroke deaths. It has been estimated that the direct and indirect costs of stroke in the United States total nearly $74 billion.

"We are in an unprecedented time, from a public health point of view, in regards to tackling stroke and other neurodegenerative disorders," concludes Dr. Bazan.

"Stroke is an outright attack on the nervous system, and each year stroke kills over 150,000 Americans,” he says. “Truly for the first time, translational research and the clinics are poised to converge in their public health efforts to combat stroke.

“From a therapeutic point of view, we can now see a light at the end of the tunnel. What we need now is for the political and societal views on stroke to converge in the same way that the research laboratories and hospitals are now doing. This would be a major step forward in fighting this disease."

Co-authors include Ludmila Belayev, MD, Larissa Khoutorova, BS, Kristal Atkins, BS, MS, Tiffany N. Eady, LSUHSC MD/PhD student, Song Hong, PhD, and Yan Lu, MD at LSU Health Sciences Center New Orleans, as well as Andre Obenaus, PhD, at Loma Linda University in California.
___
Source: Louisiana State University Health Sciences Center press release, Nov 8, 2010

 



Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid

Natural Remedies

Fatigue & Fibro Fog: Could You Have a B-12 Deficiency? Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10 Ubiquinol - A More Advanced Form of the Energy Producing Nutrient CoQ-10
The Curcumin Revolution: The Curcumin Revolution: "Golden" Ticket to Better Health
Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing