ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Fighting Heartburn and Gerd Naturally – And Safely!

Natural Bladder Control, Go Less and Live More

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Trimming the spare tire: Canola oil may cut belly fat

How Pomegranate May Protect Against Cancer

Omega Fix for Obesity: How the Right Fats Fight Fat

The Onion: Cancer Fighter and Food Preserver

Probiotics improve cognition in Alzheimer's patients

Curcumin Reverses the Cellular Damage of Chronic Stress

 
Print Page
Email Article

Anti-angiogenic effect of resveratrol or cucumin in Ehrlich ascites carcinoma-bearing mice – Source: European Journal of Pharmacology, Feb 10, 2011

  [ 29 votes ]   [ Discuss This Article ]
By Mona E-Azab, et al. • www.ProHealth.com • January 5, 2011


[Note: Malignant cells’ ability to stimulate new capillary blood vessel growth (angiogenesis) is critical to provide the oxygen and nutrients needed for tumor growth and survival. Cancer cells secrete VEGF and other factors to achieve angiogenesis. See video.]

The phytochemicals resveratrol or curcumin have been shown to possess many pharmacological activities including anti-inflammatory, anti-oxidant, anti-microbial and anti-cancer effects.

However, the underlying mechanism for their anti-tumor activity is yet to be evaluated.

The present study was carried out to investigate the anti-angiogenic effect of resveratrol or curcumin when used alone or in combination with carboplatin [chemo drug used mainly against ovarian, lung, head and neck cancers] in Ehrlich ascites carcinoma (EAC)-bearing mice. [EAC is a transplantable malignant tumor.] Solid tumors were induced by intradermal injection of EAC cells.

These tumors were used for the evaluation of microvessel density, plasma vascular endothelial growth factor (VEGF) and its intra-tumoral receptor type-2 (Flk-1). All parameters were determined as a time course on days 7, 14, and 21 post-inoculation.

Individual treatments with resveratrol or curcumin and their combination with carboplatin produced a significant reduction in microvessel density. Plasma levels of VEGF were significantly reduced in groups treated with resveratrol or curcumin and their combination with carboplatin on day 7 post-inoculation.

Treatment with resveratrol or curcumin reduced the percentage of Flk-1-rich tumors to reach 42.9% and 28.6%, respectively.

Their co-administration with carboplatin has produced a further reduction in the percentage of Flk-1-rich tumors to reach 28.6% and 14.3%, respectively.

Correlation studies showed strong association between plasma VEGF and microvessel density.

In conclusion, resveratrol or curcumin inhibited angiogenesis as demonstrated by the reduction of microvessel density by these agents. Both proved to exert their anti-angiogenic effect by inhibition of VEGF and its receptor type-2.

The results suggest the beneficial role of these phytochemicals as adjuvant to chemotherapy in the treatment of cancer.

Source: European Journal of Pharmacology, Feb 10, 2011;652(1-3). PMID: 21114990, by El-Azab M, Hishe H, Moustafa Y, El-Awady E. Department of Pharmacology and Toxicology, faculty of Pharmacy, Suez Canal University, Ismalia, Egypt. [Email: mona_azab@hotmail.com]





Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Curcumin, Longvida™ Vitamin D3 Extreme™


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Natural Resveratrol Natural Resveratrol
Powerful Antioxidant Support + Positive Anti-aging Effects
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Curcumin, Longvida™ Curcumin, Longvida™
Helps Support Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Reversing Neurodegeneration with a New Magnesium Compound Reversing Neurodegeneration with a New Magnesium Compound
Astaxanthin - A Little-Known but Power-Packed Nutrient Astaxanthin - A Little-Known but Power-Packed Nutrient
Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry
D-ficient? Health Risks You Need to Know About D-ficient? Health Risks You Need to Know About
Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map