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Oral magnesium supplementation reduces insulin resistance in non-diabetic subjects - a double-blind, placebo-controlled, randomized trial – Source: Diabetes, Obesity and Metabolism, Nov 18, 2010

  [ 14 votes ]   [ 1 Comment ]
By FC Mooren, et al. • www.ProHealth.com • January 16, 2011


The incidence of insulin resistance and metabolic syndrome correlates with the availability of magnesium (Mg). We studied the effect of oral Mg supplementation on insulin sensitivity and other characteristics of the metabolic syndrome in normomagnesemic [non-deficient], overweight, insulin resistant, non-diabetic subjects.

Subjects were tested for eligibility using oral glucose tolerance test and subsequently randomized to receive either magnesium-aspartate-hydrochloride (n = 27) or placebo (n = 25) for 6 months.

As trial endpoints several indices of insulin sensitivity, plasma glucose, serum insulin, blood pressure and lipid profile were determined.

• Mg supplementation resulted in a significant improvement of fasting plasma glucose and some ISI compared to placebo.

• Blood pressure and lipid profile didn't show significant changes.

The results provide significant evidence that oral Mg supplementation improves insulin sensitivity even in normomagnesemic, overweight, non-diabetic subjects - emphasizing the need for an early optimization of Mg status to prevent insulin resistance and subsequently type 2 diabetes.

Source: Diabetes, Obesity and Metabolism, Nov 18, 2010. Mooren FC, Krüger K, Völker K, Golf SW, Wadepuhl M, Kraus A. Department of Sports Medicine, Institute of Sports Sciences and Department of Laboratory Medicine, Justus-Liebig-University, Giessen; Department of Sports Medicine, Münster-University Hospital, Münster, Germany.





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Article Comments Post a Comment

Oral magnesium supplementation
Posted by: MSBNURSE1
Jan 19, 2011
This article needs to go to all Dr.s in private practice and most notably, endocrinologists..who treat people with diabetes!! It would not hurt for our population to also know this..but if the Dr.s have no clue..how will the public (who is not prone in searching for health advice, expecting their Dr. to tell them this) know. I changed my health status with use of the magnesium supps along with added Vitamin D each day...what a difference! I am a research nurse who was forced to find my own answers..in order to return to work.
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