ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

New Option For Chronic Fatigue Syndrome

The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol

Stop Bacteria With Nature's Antibiotics

Vitamin D Deficiency Linked to Neurological Diseases; Also Raises Risk of Asthma Attacks, and More

New Test Shows Promise in Identifying New Drugs to Treat Lyme Disease

Coenzyme Q10 Helps Veterans Battle Gulf War Illness Symptoms

Strengthen Cell Function with Energy-Boosting Niagen

Vitamin D deficiency increases poor brain function after cardiac arrest by sevenfold

Dietary Flavanols Reverse Age-Related Memory Decline

Study: Doubling saturated fat in the diet does not increase saturated fat in blood

 
Print Page
Email Article

Mass General in Boston Recruiting for Phase I Trial to Reverse Type 1 Diabetes

  [ Not Yet Rated ]   [ Discuss This Article ]
By Massachusetts General Hospital • www.ProHealth.com • March 13, 2008


Mar 13, BOSTON, Mass – Scientists at the Massachusetts General Hospital (MGH) in Boston have initiated a phase I clinical trial to reverse type 1 diabetes. The trial is exploring whether the promising results from the laboratory of Denise Faustman, MD, PhD, can be applied in human diabetes. [For details of the trial and links to the study coordinators, see the listing for Trial # NCT00607230 at ClinicalTrials.gov.]

The Trial Will Involve Tuberculosis Vaccine

Faustman’s previous studies have shown that mice with a form of diabetes that closely resembles type 1 diabetes in humans can be cured. In the animal studies, a commonly used vaccine that provides protection against tuberculosis, called Bacillus Calmette-Guerin (BCG) was used effectively to deplete the abnormal immune cells that attack and destroy the insulin producing cells of the pancreas.

The first step in the human study, which is currently enrolling volunteers, is to determine whether the same strategy using BCG vaccination can be used to modify the abnormal autoimmune cells that are present in type 1 diabetes, sometimes called “juvenile-onset” diabetes.

“We are pleased to be starting human clinical trials,” said Faustman. “Human trials take time, but we are making the step from curing diabetes in mice to determining whether it will work in men and women with diabetes.”

Type 1 diabetes usually starts during childhood or adolescence and can cause a variety of severe complications including kidney failure, loss of vision, amputations, heart disease, and strokes. It occurs when a person’s immune system attacks and destroys the insulin-producing cells in the pancreas. In the absence of insulin, which is necessary for sugar and other nutrients to enter cells, blood sugar levels rise. The risk for developing complications is closely linked to the elevated blood sugar levels over time. If blood sugar levels are well controlled, the long-term complications can largely be avoided.

However, the so-called intensive therapy that is required to maintain near-normal sugar levels requires life-long demands on the patient, including frequent blood sugar monitoring and at least 3 daily injections of insulin or use of an insulin pump, along with restrictive diets. Insulin doses must be adjusted based on blood sugar levels, dietary factors, and anticipated exercise. Thus, a cure for diabetes has been highly sought after and has attracted much research interest.

The clinical trial is using the BCG vaccine for several reasons:

  • BCG has been used safely for nearly 80 years as a tuberculosis vaccine.
  • It is now being used in the human trial because it causes a low-grade inflammatory reaction, which in the mouse model of autoimmune diabetes led to the destruction of the abnormal autoimmune cells.
  • First Step In Potentially Long Process

    David M. Nathan, MD, director of the MGH Diabetes Center, who is leading the human study at MGH, provides context, “This is the very first step in what is likely to be a long process in achieving a cure. We first need to determine whether the abnormal autoimmune cells that underlie type 1 diabetes can be knocked out with BCG vaccination, as occurred in the mouse studies.”

    * * * *

    The Phase I trial is being supported largely through direct and fundraising support from the Iacocca Foundation, and through support from other donors and the Massachusetts General Hospital. The Iacocca Foundation was founded by Lee Iacocca and his family in 1984 to fund innovative approaches to a potential cure for diabetes. Trial information is available to the public at http://www.faustmanlab.org.




    Please Discuss This Article:   Post a Comment 



    [ Be the first to comment on this article ]




     
    Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
    Subscribe to
    Our FREE
    Newsletter
    Subscribe Now!
    Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
     Privacy Guaranteed  |  View Archives

    Save on Immune Support Supplements

    Featured Products

    Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
    Supports Cognition, Memory & Overall Health
    Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
    Ultra concentrated source of essential fish oils
    Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
    Reduce Fatigue up to 45%
    Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
    50,000 IU Vitamin D3 - Prescription Strength
    Ultra ATP+, Double Strength Ultra ATP+, Double Strength
    Get energized with malic acid & magnesium

    Natural Remedies

    Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle
    The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
    Live Longer: Groundbreaking Research on Omega-3s Live Longer: Groundbreaking Research on Omega-3s
    Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
    The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12

    FIBROMYALGIA RESOURCES
    What is Fibromyalgia?
    Fibromyalgia 101
    Fibromyalgia Symptoms
    Fibromyalgia Treatments
    | CFS RESOURCES
    What is CFS?
    ME/CFS 101
    ME/CFS Symptoms
    ME/CFS Treatments
    | FORUMS
    Fibromyalgia
    ME/CFS
    ADVANCED MEDICAL LABS
    WHOLESALE  |  AFFILIATES
    GUARANTEE
    CONTACT US
    PRIVACY
    RSS
    SITE MAP
    ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
    Credit Card Processing