ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Delayed diagnosis of Lyme disease has devastating effect on patients

Missing Link Found Between Brain, Immune System - Major Disease Implications

Association of lyme disease and schizoaffective disorder, bipolar type: Is it inflammation mediated?

Adapt to Stress Naturally with These Power Herbs

Curcumin Made 65X More Bioavailable - Modern Take on a "Golden" Spice Busts Brain Fog, Joint & Body ...

Why So Many Arthritis Sufferers Fail to Find Relief

Discovering Coffee's Unique Health Benefits

Safely Manage Joint Inflammation: Curcumin

Bay Area Lyme Foundation Awards Grant to Harvard Medical School Researchers for Development of an Ac...

Therapeutic program reverses cognitive decline

 
Print Page
Email Article

Harvard EEG tests distinguish CFS from major depression patients; temporal lobe implicated

  [ 18 votes ]   [ 1 Comment ]
www.ProHealth.com • July 1, 2011


Article:
EEG spectral coherence data distinguish chronic fatigue syndrome patients from healthy controls and depressed patients - A case control study – Source: BMC (BioMed Central) Neurology, July 1, 2011

By Frank H Duffy, Anthony L Komaroff, et al.

[Note: the full text of this groundbreaking article is available here: http://www.biomedcentral.com/content/pdf/1471-2377-11-82.pdf. This report suggests that distinctive brain activity data may be used to help diagnose and/or differentiate CFS from depression, but further study is needed.]

Abstract:
Background: Previous studies suggest central nervous system involvement in chronic fatigue syndrome (CFS [ME/CFS]), yet there are no established diagnostic criteria. CFS may be difficult to differentiate from clinical depression.

The study’s objective was to determine if spectral coherence, a computational derivative of spectral analysis of the electroencephalogram (EEG), could distinguish patients with CFS from healthy control subjects and not erroneously classify depressed patients as having CFS.

Methods: This is a study, conducted in an academic medical center electroencephalography laboratory, of 632 subjects: 390 healthy normal controls, 70 patients with carefully defined CFS, 24 with major depression, and 148 with general fatigue.

Aside from fatigue, all patients were medically healthy by history and examination. EEGs were obtained and spectral coherences calculated after extensive artifact removal. Principal Components Analysis identified coherence factors and corresponding factor loading patterns.

Discriminant analysis determined whether spectral coherence factors could reliably discriminate CFS patients from healthy control subjects without misclassifying depression as CFS.

Results: Analysis of EEG coherence data from a large sample (n=632) of patients and healthy controls identified 40 factors explaining 55.6% total variance. Factors showed highly significant group differentiation (p<.0004) identifying:

• 89.5% of unmedicated female CFS patients

• And 92.4% of healthy female controls.

Recursive jackknifing showed predictions were stable.

A conservative 10-factor discriminant function model was subsequently applied, and also showed highly significant group discrimination (p<.001), accurately classifying;

• 88.9% unmedicated males with CFS,

• And 82.4% unmedicated male healthy controls.

No patient with depression was classified as having CFS.

The model was less accurate (73.9%) in identifying CFS patients taking psychoactive medications.

Factors involving the temporal lobes were of primary importance.

Conclusions: EEG spectral coherence analysis identified unmedicated patients with CFS and healthy control subjects without misclassifying depressed patients as CFS, providing evidence that CFS patients demonstrate brain physiology that is not observed in healthy normals or patients with major depression.

Studies of new CFS patients and comparison groups are required to determine the possible clinical utility of this test.

The results concur with other studies finding neurological abnormalities in CFS, and implicate temporal lobe involvement in CFS pathophysiology.

Source: BMC (BioMed Central) Neurology, July 1, 2011. doi:10.1186/1471-2377-11-82, by Duffy FH, McAnulty GB, McCreary MC, Cuchural GJ, Komaroff AJ. Departments of Neurology, Psychiatry, Children’s Hospital Boston & Harvard Medical School; Department of Medicine, Brigham & Women’s Hospital & Harvard Medical School; Department of medicine, Tufts Medical Center, Boston, Massachusetts. [Email: Anthony_komaroff@hms.harvard.edu]




Please Discuss This Article:   Post a Comment 

CFS studies vs. depressed patients
Posted by: earthdog2000
Jul 3, 2011
I had a litle trouble understanding this study due to fibrofog. It sounded like it discounted depression from CFS patients and read as if depressed patients did not have CFS if I am correct. I was also surprised that only males were included in this study! why not females since they have a higher rate of CFS and depression?
Reply Reply
 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Aches and Pains? A Simple Solution You'll Love Aches and Pains? A Simple Solution You'll Love
Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
Coping When Colds or Flu Catch Up with You
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing