ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

New Science Destroys the Saturated Fat Myth

Diet Affects Men’s and Women’s Gut Microbes Differently

New Lyme guidelines promote options and informed choice

Natural products from plants protect skin during cancer radiotherapy

Phases of clinical depression could affect treatment

“Worm pill” could ease autoimmune disease symptoms

Eating Baked or Broiled Fish Weekly Boosts Brain Health, Pitt Study Says

Scientists Look for Biomarkers to Improve Treatment of Painful Bladder Condition

New culprit identified in metabolic syndrome

Low vitamin D levels linked to increased risks after noncardiac surgery

 
Print Page
Email Article

Probiotics in gut support anxiety-easing GABA balance in brain

  [ 22 votes ]   [ Discuss This Article ]
www.ProHealth.com • September 13, 2011


Article:
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve.
– Source: PNAS, Aug 29, 2011

By Javier A Bravo, John F Cryan, et al.

There is increasing, but largely indirect, evidence pointing to an effect of commensal [beneficial] gut microbiota on the central nervous system (CNS).

However, it is unknown whether lactic acid bacteria such as Lactobacillus rhamnosus could have a direct effect on neurotransmitter receptors in the CNS in normal, healthy animals.

GABA is the main CNS inhibitory neurotransmitter and is significantly involved in regulating many physiological and psychological processes. [Inhibitory neurotransmitters calm and help balance the brain.]

Alterations in central GABA receptor expression are implicated in the pathogenesis of anxiety and depression, which are highly comorbid with functional bowel disorders. In this work, we show that:

• Chronic treatment with L. rhamnosus (JB-1) induced region-dependent alterations in GABA(B1b) mRNA in the brain with increases in cortical regions (cingulate and prelimbic) and concomitant reductions in expression in the hippocampus, amygdala, and locus coeruleus, in comparison with control-fed mice.

• In addition, L. rhamnosus (JB-1) reduced GABA(Aalpha2) mRNA expression in the prefrontal cortex and amygdala, but increased GABA(Aalpha2) in the hippocampus.

• Importantly, L. rhamnosus (JB-1) reduced stress-induced corticosterone and anxiety- and depression-related behavior.

• Moreover, the neurochemical and behavioral effects were not found in vagotomized mice, identifying the vagus as a major modulatory constitutive communication pathway between the bacteria exposed to the gut and the brain. [Vagus means ‘wandering’. The vagus nerve extends from the brain stem down, supplying nerve fibers to the ears, throat, larynx, trachea, lungs, heart, esophagus, stomach, and intestinal tract down to the colon, supporting informative and controlling transmissions to & from the brain.]

Together, these findings:

• Highlight the important role of bacteria in the bidirectional communication of the gut-brain axis, and

• Suggest that certain organisms may prove to be useful therapeutic adjuncts in stress-related disorders such as anxiety and depression.

Source: PNAS (Proceedings of the National Academy of Sciences USA), Aug 29, 2011. PMID:21876150, by Bravo JA, Forsythe P, Chew MV, Escaravage E, Savignac HM, Dinan TG, Bienenstock J, Cryan JF. Laboratory of NeuroGastroenterology, Alimentary Pharmabiotic Centre, School of Pharmacy, and Departments of Psychiatry and anatomy, University College Cork, Cork, Ireland. [Email: j.cryan@ucc.ie or bienens@mcmaster.ca.




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Your Next Order

Featured Products

Pro-Dophilus™ With FOS Pro-Dophilus™ With FOS
Friendly bacteria for complete digestive balance
Jarro-Dophilus EPS by Jarrow Formulas Jarro-Dophilus EPS by Jarrow Formulas
Enhanced probiotic system for immune health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

"It's Not Easy Being Green" - But It Is Healthy
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away
A Breakthrough for Mitochondrial Dysfunction A Breakthrough for Mitochondrial Dysfunction
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing