ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Fighting Heartburn and Gerd Naturally – And Safely!

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Natural Bladder Control, Go Less and Live More

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Trimming the spare tire: Canola oil may cut belly fat

How Pomegranate May Protect Against Cancer

Omega Fix for Obesity: How the Right Fats Fight Fat

Curcumin Reverses the Cellular Damage of Chronic Stress

The Onion: Cancer Fighter and Food Preserver

Probiotics improve cognition in Alzheimer's patients

 
Print Page
Email Article

Analgesic effects of melatonin: A review of current evidence from experimental and clinical studies – Source: Journal of Pineal Research, Oct, 2011

  [ 27 votes ]   [ 1 Comment ]
By Michael Wilhelmsen, et al. • www.ProHealth.com • September 26, 2011


[Note: To read the full text of this overview of clinical evidence for supplemental melatonin’s pain relieving effects in fibromyalgia, irritable bowel syndrome, and migraine, click HERE.]

Melatonin is an endogenous indoleamine [neurotransmitter], produced mainly by the pineal gland.

Melatonin has been proven to have chronobiotic, antioxidant, antihypertensive, anxiolytic and sedative properties. [Positively influences the body’s circadian rhythms, blood pressure, anxiety, and sleep.]

There are also experimental and clinical data supporting an analgesic [pain reducing] role of melatonin.

• In experimental studies, melatonin shows potent analgesic effects in a dose-dependent manner.

• In clinical studies, melatonin has been shown to have analgesic benefits in patients with chronic pain (fibromyalgia, irritable bowel syndrome, migraine).

The physiologic mechanism underlying the analgesic actions of melatonin has not been clarified. The effects may be linked to G(i)-coupled melatonin receptors, to G(i)-coupled opioid mu-receptors or GABA-B receptors with unknown downstream changes with a consequential reduction in anxiety and pain.

Also, the repeated administration of melatonin improves sleep and thereby may reduce anxiety, which leads to lower levels of pain.

In this paper, we review the current evidence regarding the analgesic properties of melatonin in animals and humans with chronic pain.

Source: Journal of Pineal Research, Oct 2011; 51(3):270-7. PMID:21615490, by Wilhelmsen M, Amirian I, Reiter RJ, Rosenberg J, Gögenur I. Department of Surgical Gastroenterology, Herlev Hospital, University of Copenhagen, Herlev, Denmark; Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, USA.





Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Melatonin Sublingual Tablets FibroSleep™


Article Comments Post a Comment

melatonin
Posted by: SPIDEEKMON
Oct 13, 2011
J Physiol Pharmacol. 2008 Aug;59 Suppl 2:33-51. Thirty four years since the discovery of gastrointestinal melatonin. Bubenik GA. Department of Integrative Biology, University of Guelph, Guelph, Ontario, Canada. gbubenik@uoguelph.ca Abstract After the discovery of melatonin in the pineal gland by Lerner and co-workers in 1958, melatonin was also detected in the retina and the human appendix. Later, melatonin was confirmed immunohistologically in all segments of the gastrointestinal tract (GIT), in the guts of bovine embryos and in the GIT of low vertebrates. Melatonin was also confirmed in the pancreas and the hepatobiliary system. Melatonin is produced in the enteroendocrine cells of the GIT mucosa. The concentrations of melatonin in the GIT are 10-100x higher than in the plasma and the total amount of melatonin in the GIT is around 400x higher than the amount of melatonin in the pineal gland. Similar to pineal melatonin, GIT melatonin is a multifunctional compound which exhibits some general as well as some specific effects, depending on the organ and the location of GIT tissue. In the GIT, melatonin exhibits endocrine, paracrine, autocrine and luminal actions. Generally, the episodic secretion of melatonin from the GIT is related to the intake and digestion of food and to the prevention of tissue damage caused by hydrochloric acid and digestive enzymes. Some actions, such as the scavenging of hydroxyl free radicals, immunoenhancement and antioxidant effects are of general nature, whereas others, such as an increase of mucosal blood flow, the reduction of peristalsis and the regulation of fecal water content, are specific to the tubular GIT. Generally, melatonin actions oppose those of serotonin. Laboratory and clinical studies indicate that the utilization of melatonin can prevent or treat pathological conditions such as esophageal and gastric ulcers, pancreatitis, colitis, irritable bowel disease, and colon cancer. AND THERE'S MORE!!
Reply Reply
 
Natural Pain Relief Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Melatonin Sublingual Tablets Melatonin Sublingual Tablets
Supports Deep, Restful Sleep Naturally
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Optimize Your Immune System Naturally: Thymic Protein A Optimize Your Immune System Naturally: Thymic Protein A
D-ficient? Health Risks You Need to Know About D-ficient? Health Risks You Need to Know About
Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value
Coenzyme Q10 - The Energy Maker Coenzyme Q10 - The Energy Maker
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map