ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|
 
Print Page
Email Article

Gulf War Illness culprit list hones in on pyrostigmine bromide & pesticides, which differed by deployment area

  [ 10 votes ]   [ Post a Comment ]
www.ProHealth.com • September 29, 2011

previous article next article

Article:
Complex Factors in the Etiology of Gulf War Illness: Wartime Exposures and Risk Factors in Veteran Subgroups
– Source: Environmental Health Perspectives, Sep 19, 2011

By Lea Steele, et al.

[Note: to read a PDF of the full text report click HERE and select “download: PDF”]

Background:
At least one fourth of U.S. veterans who served in the 1990-1991 Gulf War are affected by the chronic symptomatic illness known as Gulf War illness (GWI). Clear determination of the causes of GWI has been hindered by many factors, including limitations in how epidemiologic studies have assessed the impact of the complex deployment environment on veterans’ health.

Objective: To address GWI etiologic questions by evaluating the association of symptomatic illness with characteristics of veterans’ deployment.

Methods. Veteran-reported wartime experiences were compared in a population-based sample of 304 Gulf War veterans: 144 cases who met pre-established criteria for GWI and 160 controls.

Analyses considered veteran subgroups and confounding among deployment variables.

Results:

Deployment experiences and the prevalence of GWI differed significantly by veterans’ location in theater.

Among personnel who were in Iraq or Kuwait, where all battles took place:

• GWI was most strongly associated with using pyridostigmine bromide* pills (OR=3.5, CI=1.7-7.4) [Note: an odds ratio of 1.0 would indicate no increased odds of GWI vs controls. An OR of 3.5 would indicate 250% increased odds of subsequent GWI, on average, among those using pyridostigmine bromide pills.]

• And being within one mile of an exploding SCUD missile (OR=3.1, CI=1.5-6.1).

For veterans who remained in support areas:

• GWI was significantly associated only with personal pesticide use,

• With increased prevalence (OR=12.7, CI=2.6-61.5) in the relatively small subgroup who wore pesticide-treated uniforms, nearly all of whom also used skin pesticides. [The OR of 12.7 indicates 1,170% greater odds of subsequent GWI in this subgroup vs. controls.]

Combat service was not significantly associated with GWI.

Conclusions:

Findings support a role for a limited number of wartime exposures in the etiology of GWI, which differed in importance with the deployment milieu in which veterans served.

[* Ed Note: Pyridostigmine bromide is a drug that was used in hopes of preventing death from possible exposure to the ‘nerve gas’ Soman. It was a drug that had been tested only in animals for that purpose but received FDA approval as an investigational agent only for use by military personnel in combat. As a drug, it is used as a muscle stimulant for those with the autoimmune neuromuscular disorder myasthenia gravis. It is believed to ‘Facilitate myoneural junction impulse transmission by inhibiting acetylcholine destruction by cholinesterase.’ According to this article, of the 64 pesticides used during the Gulf War, 15 have been designated 'pesticides of concern' including permethrin, used on uniforms; DEET; and lindane powder, also applied to uniforms. Notably, for example, applications of permethrin where used averaged 30 per month vs. the recommended 1 every six weeks.]

Source: Environmental Health Perspectives, Sep 19, 2011. http://dx.doi.org/10.1289/ehp.1003399, by Steele L, Sastre A, Gerkovich MM, Cook MR. Institute of Biomedical Studies, Baylor University, Waco, Texas; Midwest Research Institute, Kansas City, Missouri; Department of Biomedical and Health Informatics, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA. [Email: Lea_Steele@baylor.edu]



previous article
  Rating 4.1 (10 votes) next article




DISCUSS THIS ARTICLE   (0 existing comments) Post a Comment 




[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Your Next Order

Featured Products
Omega 3-6-9 Omega 3-6-9
All three EFAs in one convenient form
OsteoTec™ UC-II® OsteoTec™ UC-II®
A True Breakthrough in Joint health
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Vitamin D3 5000 IU Vitamin D3 5000 IU
Give your body a boost with the sunshine vitamin
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Most Viewed Articles
What's the Hidden Cause Behind YOUR Fibromyalgia Flares? [more]

Pridgen Reports Fibromyalgia Antiviral Trial Results “Very Positive”: Predicts New Approach Will Be ... [more]

Massage Therapy Studies for Fibromyalgia Reviewed [more]

How to Limit or Minimize Your Fibromyalgia Flare [more]

Mitochondrial Dysfunction, Post-Exertional Malaise and CFS/ME [more]

The Devil Is In The Details – A Herpes Simplex Virus Inquiry For Fibromyalgia and Chronic Fatigue Sy... [more]

Sympathetic Nervous System Dysfunction in FIbromyalgia and Overlapping Conditions [more]

VIDEO: IACFS/ME Conference - Summary of Research by Dr. Komaroff [more]

Review of Nutritional Supplements Used for ME/CFS and FM [more]

FREE: Stop Feeding Yourself PAIN Guide [more]


FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing