Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Acupuncture used in clinical settings reduced symptoms of menopause

Benefits of Coconut Oil Are Undeniable

How Awesome Is Ashwagandha?

CoQ10 supplementation associated with lower pro-inflammatory factors in randomized trial

SURVEY RESULTS: Should Opioids Be Restricted for Chronic Illness?

Clinical trial demonstrates success of low FODMAP diet

Research Demonstrates Superiority of Krill Oil Compared to Fish Oil

What’s so Remarkable About Rosemary?

Vitamin nicotinamide riboside protects mice from diabetes complications

Turmeric: The Spice of Life

 
Print Page
Email Article

Researchers revive immune cells exhausted by chronic viral infection to fight another day

  [ 13 votes ]   [ Discuss This Article ]
www.ProHealth.com • December 14, 2011


Based on success in animal trials, a number of labs are intensively pursuing techniques for removing virus-sensing human helper T cells, stimulating them, and reintroducing them to reinvigorate their exhausted virus-killing henchmen.

Chronic viral infections eventually take hold because they wear the immune system out, a phenomenon immunologists describe as exhaustion.

But exhausted immune cells can be revived after the introduction of fresh cells that act like coaches giving a pep talk, researchers at Emory University’s Vaccine Center have found.

Their findings provide support for an emerging strategy for treating chronic infections: Infusing immune cells back into patients after a period of conditioning.

The results were published Dec 12 by Proceedings of the National Academy of Sciences (“Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection.”)

The team, led by Drs. Rafi Ahmed (director of Emory’s Vaccine Center) and Rachael Aubert (Emory's Immunology and Molecular Pathogenesis program) have extensive experience studying mice infected with lymphocytic choriomeningitis virus (LCMV). Immune responses against LCMV are driven by CD8 or "killer" T cells, which destroy virus-infected cells in the body.

[As William Collinge describes them in his plain language overview of the immune system, CD8 T killer cells are like satellite dishes that have receptors on their surface for receiving signals from CD4 T helper cells (watchdog cells that sense the presence of invaders and send out APBs on them). The CD8 T killer cells then home in on the unwanted infected cells and inject poison into them.]

But a few weeks after exposure to LCMV, the mice develop a chronic infection that their immune systems cannot shake off, similar to when humans are infected by viruses like HIV and hepatitis C.

The team examined what happened to mice chronically infected with LCMV when they infused CD4 helper T cells from uninfected mice.

After the infusion, the CD8 cells in the infected mice revived and the levels of virus in their bodies decreased by a factor of four after a month.

Like coaches encouraging a tired athlete, the helper cells drove the killer cells that were already in the infected mice to emerge from exhaustion and re-engage.

The cell-based treatment was especially effective when combined with an antibody that blocks the molecule PD-1, which appears on exhausted T cells and inhibits their functioning.

Ten-Fold Reduction in Virus, Sometimes to Undetectable Levels

The antibody against PD-1 helps the exhausted killer T cells to revive, and enhances the function of the helper T cells as well: The combination reduced viral levels by roughly ten-fold, and made the virus undetectable in some mice.

"We have not seen this sharp a reduction in viral levels in this system before," says co-author Alice Kamphorst. The helper cells were all genetically engineered to recognize LCMV, a difference between mouse experiments and potential clinical application, she explains. But it may be possible to remove helper T cells from a human patient and stimulate them so that all the cells that recognize a given virus grow.

"This is an active area of research and several laboratories are looking at how best to stimulate T cells and re-introduce them," she says. In addition, she and her co-workers are examining what types of hormones or signaling molecules the helper cells provide to the killer cells. That way, that molecule could be provided directly, instead of by cell therapy, she says.

The molecule PD-1 was previously identified by Ahmed and colleagues as a target for therapy designed to re-activate exhausted immune cells. Antibodies against PD-1 have been undergoing tests in clinical studies against hepatitis C and several forms of cancer.

Collaborators from Harvard Medical School/Dana Farber Cancer Institute contributed to the paper. The research was supported by the National Institutes of Health and the Cancer Research Institute.

Source: Based on Emory University news release Dec 13, 2011




Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Vitamin D3 Extreme™ Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Dr Axe Bone Broth Proteins

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Enhance Eyelashes Naturally Enhance Eyelashes Naturally
The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health The Revolutionary 'Good Fat' That Promotes Heart, Brain, Bone and Joint Health
Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
How I Found My Long-Lost Energy How I Found My Long-Lost Energy
Natural Relief for Soreness, Pain and Swelling – Putting Out the Fire

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map