ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Mitochondria-Booster NIAGEN® Shows Promise in First Human Clinical Trial

Can Glycine + Amino Acids Be the Secret to Deep, Rejuvenating Sleep?

Exploring the association between Morgellons disease and Lyme disease: identification of Borrelia bu...

Lyme Disease Activists Take Fight to Washington D.C.

New Envita Study Shows Chronic Lyme Disease "Fools" Immune System, Resistant to Antibiotics

Safely Burn Away Body Fat

Omega-3 fatty acids boost B vitamin brain benefit

Substantial health threat: Never-before-seen tick-borne disease

Lyme Advocates Call on IDSA to Focus on Patient Care Instead of Attacking Those in Distress

Zinc deficiency linked to chronic inflammation

 
Print Page
Email Article

'Subclinical’ B-12 deficiency - very common in older adults & may be related to cognitive decline

  [ 15 votes ]   [ Discuss This Article ]
www.ProHealth.com • February 27, 2012


Article:
Subclinical cobalamin [B-12] deficiency
– Source: Current Opinion in Gastroenterology, Mar 2012

By Ralph Carmel

[Note: cobalamin is vitamin B-12. “Normal” findings on serum B12 tests actually leave a large gray area between definitely deficient (clinical deficiency) and definitely sufficient. Cases of deficiencies within that gray area appear often associated with cognitive decline.]

Abstract:
Purpose of review: This review focuses on recent developments and controversies in the diagnosis, consequences, and management of subclinical cobalamin deficiency (SCCD), which affects many elderly persons.

Recent findings: Diagnosis of subclinical cobalamin deficiency depends exclusively on biochemical tests whose individual limitations suggest that combinations of tests are needed, especially in epidemiologic research.

The causes of subclinical cobalamin deficiency are unknown in more than 60% of cases, which limits prognostic predictions and identification of health consequences.

After years of varying, often inconclusive associations, new clinical trials suggest that homocysteine [a risk marker for cardiovascular disease, Alzheimer’s & Parkinson’s] reduction by high doses of folic acid [B-9]), cobalamin [B-12], and pyridoxine [B-6] may reduce progression of structural brain changes and cognitive impairment, especially in predisposed individuals.

• The causative or contributory roles, if any, of subclinical cobalamin deficiency itself in cognitive dysfunction require direct study.

• If the findings are confirmed, high-dose supplementation with three vitamins will probably be more effective than fortification of the diet.

Summary: The story of subclinical cobalamin deficiency which is severalfold times more common in the elderly than clinical cobalamin deficiency, but also differs from it in arising only infrequently from severe malabsorption and thus being less likely to progress, continues to evolve.

Preventive benefits need to be confirmed and expanded, and will require fuller understanding of subclinical cobalamin deficiency pathophysiology, natural history, and health consequences.

Source: Current Opinion in Gastroenterology, Mar 2012; 28(2) pp 151–158. Carmel R. Department of Medicine, New York Methodist Hospital, Brooklyn and Weill Cornell Medical College, New York, New York, USA.
 



Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Curcumin - a Golden Gift of Nature with Benefits Still Untold Curcumin - a Golden Gift of Nature with Benefits Still Untold
SAD? Coping with Seasonal Affective Disorder
Eating Fat is Good… Maybe… Could Be… Sometimes Eating Fat is Good… Maybe… Could Be… Sometimes
Coping When Colds or Flu Catch Up with You
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing