Activate Now
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

How One LLND Treats Lyme disease and Co-infections Using Natural Medicine

Surprising Benefits of Cinnamon

New depression diagnosis and treatment

Specific vitamin D levels linked to heart problems

A Sleep Intervention For Children With Autism: A Pilot Study

Higher vitamin D levels may be protective against acute rhinosinusitis

Basic Vitamin A Primer

Saffron reduces oxidative stress in metabolic syndrome patients

Pilot Study: Measuring Relaxation Response to the iLs Dreampad

Print Page
Email Article

‘Hybrid’ aspirin curbs cancer cell growth, shrinks tumors without harm to healthy cells

  [ 18 votes ]   [ Discuss This Article ] • March 10, 2012

“If what we have seen in animals can be translated to humans, it could be used in conjunction with other drugs to shrink tumors before chemotherapy or surgery.” – Dr. Khosrow Kashfi, City College of New York

The humble aspirin may soon have a new role, say researchers at CCNY. They’ve developed a new compound using classic aspirin as a 'scaffold' that has great promise to be a very potent cancer-fighter - but also safer than the aspirin we know. They recently published findings from two trials - one treating cancer cell cultures and one treating animals with tumors.

The new designer aspirin curbed the growth of 11 different types of human cancer cells in culture…
…(including leukemia and colon, pancreatic, lung, prostate and breast cancer cells) without harming normal cells, according to a report published by ACS Medicinal Chemistry Letters. [See full text here.]

“The key components of this new compound are that it is very, very potent and yet it has minimal toxicity to the cells,” says principal investigator Khosrow Kashfi, PhD, a pharmaceutical biochemist at CCNY.

The aspirin compound also shrank human colon cancer tumors by 85% in live animals…
…again without adverse effects, according to the second paper in Biochemical and Biophysical Research Communications [see before & after photos of mice treated for human colon cancer tumors here]. This paper was published by the CCNY team with colleague Kenneth Olson, PhD, of Indiana University School of Medicine, South Bend.

“If what we have seen in animals can be translated to humans, it could be used in conjunction with other drugs to shrink tumors before chemotherapy or surgery,” says Dr. Kashfi

About NOSH: Two Molecules Increase Aspirin Safety, Potency

Long the go-to drug for minor aches and pains, aspirin and other so-called NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen and naproxen, are known primarily for their ability to calm inflammation. Studies in the 1980’s resolved a decades-old debate on the utility of a daily dose of aspirin to cut the risk of heart attack and stroke.

More recent studies tracking regular use of the drug and other NSAIDs demonstrated their remarkable ability to inhibit the growth of cancer. “There’s a lot of data on aspirin showing that when taken on a regular basis, on average it reduces the risk of development of colon cancer by about 50% compared to nonusers,” notes Dr. Kashfi.

The fly in the ointment has been that prolonged use of aspirin posed its own dangers: side effects ranging from bleeding ulcers to kidney failure.

To resolve this, the researchers created a hybrid of two earlier formulations, which they have called “NOSH-aspirin.” They used the aspirin as a scaffold to support two molecules that have been shown to increase the drug’s safety and potency.

• One arm of the hybrid aspirin releases nitric oxide (NO), which helps protect the stomach lining.

• The other releases hydrogen sulfide (H2S), which the researchers have previously shown enhances aspirin’s cancer-fighting ability.

The researchers suspected that the hybrid would be more effective than either of the two components alone to boost aspirin’s safety and power against cancer. “The hybrid is more potent - and it is more potent by orders of magnitude - compared to aspirin,” Dr. Kashfi says. Only 24 hours after treating a culture of cancer cells, the NOSH-aspirin demonstrated 100,000 times greater potency than aspirin alone.

“At 72 hours it is about 250,000 times more potent in an in-vitro cell culture against human colon cancer,” Dr. Kashfi adds. “So you need a lower amount to get the same result.”

The effect of the hybrid was also far greater than the sum of its parts. Its potency was as much as 15,000 times greater than existing NO-aspirins and 80-fold more than those that incorporate H2S. The upshot is that a drug based on this hybrid would require lower doses to be effective, minimizing or potentially eliminating its side effects.

In the second study, when mice bearing human colon cancer tumors on their flanks were given oral NOSH-aspirin, the compound:

• Caused cancer cells to self-destruct,

• Inhibited the proliferation of the cells and significantly reduced tumor growth,

• Without any signs of toxicity in the mice.

The stage is set for the development of a drug based on NOSH-aspirin, Dr. Kashfi notes.

But any routine working therapy for humans is years away, the next steps being toxicity testing, and then human clinical trials.

Dr. Ravinder Kodela and Dr. Mitali Chattopadhyay are members of Professor Kashfi’s lab at CCNY's Sophie Davis School of Biomedical Education and co-authors on both papers. These studies were funded by The National Cancer Institute through a subcontract from ThermoFisher, and also by the National Science Foundation. 

Dr. Kashfi and his colleagues will present these findings at the annual meeting of the American Association for Cancer Research in Chicago, Mar 31 - Apr 4.

Source: Based on City College of New York news release, Mar 8, 2012


1. [Full text.] “NOSH-Aspirin: A Novel Nitric Oxide–Hydrogen Sulfide-Releasing Hybrid: A New Class of Anti-inflammatory Pharmaceuticals,” by Kodela R, Chattopadhyay M, Kashfi K. ACS Medicinal Chemistry Letters, Jan 28, 2012

2. [Scroll down for before & after photos of rats’ tumors.] “NOSH–aspirin (NBS-1120), a novel nitric oxide- and hydrogen sulfide-releasing hybrid is a potent inhibitor of colon cancer cell growth in vitro and in a xenograft mouse model,”  by Chattopadhyay M, Kodela R, Olson KR, Kashfi K. Biochemical and Biophysical Research Communications, Feb 16, 2012.

Post a Comment

Featured Products From the ProHealth Store
Ultra ATP+, Double Strength Ultra EPA  - Fish Oil Vitamin D3 Extreme™

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Subscribe Now!
Receive up-to-date ME/CFS, Fibromyalgia & Lyme Disease treatment and research news
 Privacy Guaranteed  |  View Archives

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium

Natural Remedies

Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed Fight Inflammation and Promote Cognitive Health with High-OPC Grape Seed
Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol The Most Powerful Natural Antioxidant Discovered to Date - Hydroxytyrosol
Natural Support for Mood, Sleep and Mental Focus? L-theanine Natural Support for Mood, Sleep and Mental Focus? L-theanine
Guarding Against the Dangers of Vitamin D Deficiency Guarding Against the Dangers of Vitamin D Deficiency

What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Causes
Fibromyalgia Treatments
Fibromyalgia Diet
Fibromyalgia Medications
M.E. & CFS
What is M.E./CFS?
M.E./CFS Diagnosis
M.E./CFS Symptoms
M.E./CFS Causes
M.E./CFS Treatments
M.E./CFS Diet
M.E./CFS Medications
What is Lyme Disease?
Lyme Disease Diagnosis
Lyme Disease Symptoms
Lyme Disease Causes
Lyme Disease Treatments
Lyme Disease Diet
Lyme Disease Medications
M.E. & CFS
Lyme Disease
General Health
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing