Activate Now
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

How One LLND Treats Lyme disease and Co-infections Using Natural Medicine

Higher vitamin D levels may be protective against acute rhinosinusitis

VIDEO: The Truth About Sugar - New Science Documentary 2015

Vitamin D supplementation associated with improved exercise performance

Pilot Study: Measuring Relaxation Response to the iLs Dreampad

Saffron reduces oxidative stress in metabolic syndrome patients

Specific vitamin D levels linked to heart problems

'Healthy' foods differ by individual

Irritable bowel syndrome may be associated with maternal inheritance and mitochondrial DNA control r...

Print Page
Email Article

New Hope for Neuropathic Pain: Drug Keeps Nerve-Calming Potassium Channels Open

  [ 36 votes ]   [ Discuss This Article ] • May 23, 2012

New medication, already licensed & headed for clinical trials, "could bring relief to hundreds of millions."

Neuropathic pain (aka nerve pain or neuropathy) involves impulses from damaged, sensitive nerve fibers which are felt, for example, as tingling, burning, or stabbing sensations. Nerve pain often becomes chronic and can be disabling, and commonly develops in diabetes, lupus, shingles, complex regional pain syndromes, sciatica, phantom limb pain, MS, Parkinson's, post-stroke pain, and more.

Nerve pain is hard to alleviate with commonly used over-the-counter analgesics such as paracetamol or ibuprofen, or even morphine.

But a drug developed at Tel Aviv University – dubbed BL 7050 – offers new hope for people suffering with neuropathic pain.

According to the developers, Drs. Bernard Attali and Asher Peretz, working in the Sackler School of Medicine's Attali lab:

• BL 7050, delivered in pill form, has been demonstrated in pre-clinical animal trials to efficiently inhibit transmission of pain signals and epileptic seizures as well. It does this by avoiding nerve fiber hyperexcitement. While on the medication, rats experiencing both epilepsy and neuropathic pain were no longer affected by stimuli that had previously caused pain. Measures in the electrical activities of neurons also revealed that the medication was able to induce "calm" in the neurons, inhibiting pain pathways.

• BL 7050 has already been licensed for development & commercialization via Tel Aviv University’s technology transfer arm.

• And will move to clinical trials in humans “in the near future.”

The Quest to Stabilize Cellular Potassium Channels

As the researchers have reported in the journal PNAS as their work progressed, the medication works by targeting a group of proteins which act as channels or ‘pores’ in membranes of cells – allowing potassium to flow readily across the membrane. Understanding the  the mechanism that controls these potassium channels was crucial to development of the drug.

• Potassium has a crucial role in the excitability of cells, specifically those in the nervous system and the heart.

• When potassium channels don't function properly, cells are prone to hyper-excitability, leading to neurological and cardiovascular disorders such as epilepsy and arrhythmias.

• These are also the channels that convey pain signals caused by nerve or tissue damage, known as neuropathic pain.

• The researchers set out to develop a medication that could bind to and stabilize the body's potassium channels, controlling their hyper-excitability and preventing the occurrence of pain by keeping the channels open for the outflow of potassium.

• And, subject to upcoming phase one clinical trials, BL 7050 so far appears to fit the bill.

Source: Adapted from Friends of Tel Aviv University Press Release, Apr 30, 2012

Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Optimized Curcumin Longvida® Energy NADH™ 12.5mg

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments

Be the first to comment on this article!

Post a Comment

Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Subscribe Now!
Receive up-to-date ME/CFS, Fibromyalgia & Lyme Disease treatment and research news
 Privacy Guaranteed  |  View Archives

Repair Damaged Mitochondria and Reduce Fatigue Up to 45%

Featured Products

FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function

Natural Remedies

Carry a Massage Therapist in Your Pocket Carry a Massage Therapist in Your Pocket
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
Stop Bacteria With Nature's Antibiotics Stop Bacteria With Nature's Antibiotics
Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue Magnesium + Malic Acid: One-Two Punch for Pain & Fatigue
The Surprising Benefits of Probiotics - What You Didn't Know The Surprising Benefits of Probiotics - What You Didn't Know

What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Causes
Fibromyalgia Treatments
Fibromyalgia Diet
Fibromyalgia Medications
M.E. & CFS
What is M.E./CFS?
M.E./CFS Diagnosis
M.E./CFS Symptoms
M.E./CFS Causes
M.E./CFS Treatments
M.E./CFS Diet
M.E./CFS Medications
What is Lyme Disease?
Lyme Disease Diagnosis
Lyme Disease Symptoms
Lyme Disease Causes
Lyme Disease Treatments
Lyme Disease Diet
Lyme Disease Medications
M.E. & CFS
Lyme Disease
General Health
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing