ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Ultrasound Therapy for Fibromyalgia and Lyme Disease

Curcumin: The All In One Solution, Part 2

What Are the Benefits of Vitamin K2?

Vitamin D deficiency + high fat diet = metabolic syndrome

Why You Should Take Your Apple Cider Vinegar at Night

Use Burdock Oil to Promote Healthy Hair Growth

Meet Your Weight Loss Goals

People with forms of early-onset Parkinson's disease may benefit from boosting niacin in diet, resea...

AMA journal associates iron deficiency with hearing loss

Why the Mediterranean Diet Is so Successful

 
Print Page
Email Article

B-cell alterations in ME/CFS ‘may suggest subtle tendency to autoimmunity’

  [ 9 votes ]   [ Discuss This Article ]
www.ProHealth.com • December 4, 2012


Article:
Altered functional B-cell subset populations in patients with chronic fatigue syndrome compared to Healthy Controls
- Source: Clinical & Experimental Immunology, Nov 2012

By A.S. Bradley, B. Ford, A.S. Bansal

[Note: This article, abstracted below, is not yet available in formatted full text. The research took place at an NHS center serving ME/CFS patients in southwest London and Surrey.]

Abstract:
Chronic Fatigue Syndrome (CFS) is a heterogeneous disorder of unknown aetiology characterised by disabling fatigue, headaches, sleep disturbance and several other symptoms.

The onset of CFS may follow a viral infection or period of stress. Patients with CFS do not have hypogammaglobulinaemia, predisposition to recurrent bacterial infections or symptoms of autoimmunity.

To date, defects in B-cell numbers or function have not been shown in the literature. [In autoimmune disorders such as RA, immune B cells mistakenly attack self.] However, treatment with anti-B-cell therapy using Rituximab has recently shown benefit to CFS patients.

We therefore postulated that patients with CFS had a subtle humoral [found in the body fluids] immune dysfunction, and performed extended B-cell immunophenotyping.

We undertook a detailed characterization of the proportions of the different B-cell subsets in 33 patients with CFS fulfilling the Canadian and Fukuda criteria for CFS and compared these with 24 age and gender matched healthy controls (HC).

CFS patients had:

• Greater numbers of naïve B-cells as a % lymphocytes - 6.3 % versus 3.9 % in HC (P=0.034),

• Greater numbers of naïve B-cells as a % of B-cells - 65 % versus 47 % in controls (P=0.003),

• Greater numbers of transitional B-cells - 1.8 % versus 0.8 % in controls (P=0.025)

• And reduced numbers of plasmablasts - 0.5 % versus 0.9 % in controls (P=0.013).

While the cause of these changes is unclear, we speculate whether they may suggest a subtle tendency to autoimmunity.

Source: Clinical & Experimental Immunology, abstract online Nov 2012, full text article not yet formatted. DOI: 10.1111/cei.12043, by Bradley AS, Ford B, Bansal AS. Department of Immunology, St. Helier University Hospital NHS Trust, Carshalton, Surrey, UK. [Email: Amolak.Bansal@esth.nhs.uk]





Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Ultra ATP+, Double Strength Mitochondria Ignite™ with NT Factor®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Herbal Inflammation Management for Whole Body Health Herbal Inflammation Management for Whole Body Health
Sleep Like a Baby in Nature's Cradle Sleep Like a Baby in Nature's Cradle
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
Aching Muscles? Top 10 Nutrients to Take Back Your Life Aching Muscles? Top 10 Nutrients to Take Back Your Life
Breaking Through the Mental Fog Breaking Through the Mental Fog

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map