ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Top 3 Nutrients to Detox the Liver and Soothe Digestion

Natural Bladder Control, Go Less and Live More

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Omega Fix for Obesity: How the Right Fats Fight Fat

How Pomegranate May Protect Against Cancer

Trimming the spare tire: Canola oil may cut belly fat

The Onion: Cancer Fighter and Food Preserver

Safely Reduce a Common Cause of Stomach Distress

 
Print Page
Email Article

Tumor Necrosis Factor-alpha Blocks Differentiation and Enhances Suppressive Activity of Immature Myeloid Cells during Chronic Inflammation

  [ Not Yet Rated ]   [ 1 Comment ]
By M. Sade-Feldman et al. • www.ProHealth.com • April 6, 2013


Editor's Comment: A number of studies have found elevated inflammatory cytokines in patients with CFS/ME. In 1999, Moss et al. discovered that TNF-a was elevated in CFS patients. Maes et al. confirmed this finding in 2011. Elevated levels of inflammatory cytokines, including TNF-a, have also been found in fibromyalgia patients. (Read the abstract HERE.Zeta chain downregulation has been implicated in cancer and in autoimmune diseases.

~Source: Immunity, Volume 38, Issue 3, 541-554, 07 March 2013

By M. Sade-Feldman et al.

Highlights

  • TNF-a promotes immunosuppression during chronic inflammation via MDSCs
  • TNF-a blocks MDSC maturation by enhancing S100A8/9 and RAGE expression
  • TNF-a augments MDSC suppressive activity impairing T and NK cell function
  • Etanercept enhances MDSC maturation and reduces their suppressive activity

Summary

Elevated concentrations of tumor necrosis factor-a (TNF-a) are detected in pathologies characterized by chronic inflammation. Whether TNF-a plays a role in manipulating the host’s immune system toward generating an immunosuppressive milieu, typical of ongoing chronic inflammation, is unclear. Here we showed that TNF-a exhibited a dual function during chronic inflammation: arresting differentiation of immature myeloid-derived suppressor cells (MDSCs) primarily via the S100A8 and S100A9 inflammatory proteins and their corresponding receptor (RAGE) and augmenting MDSC suppressive activity. These functions led to in vivo T and NK cell dysfunction accompanied by T cell antigen receptor zeta chain downregulation. Furthermore, administration of etanercept (TNF-a antagonist) during early chronic inflammatory stages reduced MDSCs’ suppressive activity and enhanced their maturation into dendritic cells and macrophages, resulting in the restoration of in vivo immune functions and recovery of zeta chain expression. Thus, TNF has a fundamental role in promoting an immunosuppressive environment generated during chronic inflammation.

Source: Immunity, Volume 38, Issue 3, 541-554, 07 March 2013. Sade-Feldman M, Kanterman J, Ish-Shalom E, Elnekave M, Horwitz E, Baniyash M. The Lautenberg Center for General and Tumor Immunology, The Institute for Medical Research Israel-Canada.





Post a Comment

Featured Products From the ProHealth Store
Energy NADH™ 12.5mg Ultra ATP+, Double Strength Vitamin D3 Extreme™


Article Comments Post a Comment

TNF-a
Posted by: IanH
Apr 6, 2013
Also reduces mitochondrial membrane potential gradient when chronically elevated. This in turn leads to many of the symptoms in ME/CFS
Reply Reply
 
Natural Pain Relief Supplements

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health

Natural Remedies

Optimize Your Immune System Naturally: Thymic Protein A Optimize Your Immune System Naturally: Thymic Protein A
Carry a Massage Therapist in Your Pocket Carry a Massage Therapist in Your Pocket
Live Without Anxiety or Stress Live Without Anxiety or Stress
Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
Top 3 Nutrients to Detox the Liver and Soothe Digestion Top 3 Nutrients to Detox the Liver and Soothe Digestion

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map