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Detection of Mycotoxins in Patients with Chronic Fatigue Syndrome

  [ 5 votes ]   [ 1 Comment ]
By Joseph H. Brewer et al. • • April 12, 2013

Note: The full article is available as a PDF download HERE.

By Joseph H. Brewer et al.

Abstract: Over the past 20 years, exposure to mycotoxin producing mold has been recognized as a significant health risk. Scientific literature has demonstrated mycotoxins as possible causes of human disease in water-damaged buildings (WDB). This study was conducted to determine if selected mycotoxins could be identified in human urine from patients suffering from chronic fatigue syndrome (CFS).

Patients (n = 112) with a prior diagnosis of CFS were evaluated for mold exposure and the presence of mycotoxins in their urine. Urine was tested for aflatoxins (AT), ochratoxin A (OTA) and macrocyclic trichothecenes (MT) using Enzyme Linked Immunosorbent Assays (ELISA). Urine specimens from 104 of 112 patients (93%) were positive for at least one mycotoxin (one in the equivocal range). Almost 30% of the cases had more than one mycotoxin present. OTA was the most prevalent mycotoxin detected (83%) with MT as the next most common (44%). Exposure histories indicated current and/or past exposure to WDB in over 90% of cases. Environmental testing was performed in the WDB from a subset of these patients.

This testing revealed the presence of potentially mycotoxin producing mold species and mycotoxins in the environment of the WDB. Prior testing in a healthy control population with no history of exposure to a WDB or moldy environment (n = 55) by the same laboratory, utilizing the same methods, revealed no positive cases at the limits of detection.

SourceToxins 2013, 5(4), 605-617; doi:10.3390/toxins5040605. Joseph H. Brewer, Jack D. Thrasher, David C. Straus, Roberta A. Madison, and Dennis Hooper

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Article Comments Post a Comment

important findings
Posted by: richcarson
Apr 12, 2013
What makes these findings more important is that many ME patients have hypersensitive immune responses to foreign substances/antigens.
Reply Reply
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