ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

10 Fibro-Friendly Foods with a Bonus: Beautiful Skin

Fight Back! Win the War Being Waged Against Your Immune System

Studies Show that Magnesium L-threonate Improves Brain Plasticity, Leading to Direct and Significant...

Clary Sage Oil May Be Pricey, but Its Benefits Are Priceless

Component of red wine, grapes can help to reduce inflammation, study finds

Poly MVA: A Novel Therapy for Increasing Energy, Repairing DNA, and Promoting Overall Health

Pumpkin Pie Turmeric Breakfast Smoothie - Vegan + Gluten-Free

Vitamin D supplementation extends life in mouse model of Huntington's disease

What’s Fenugreek Good For?

Omega-3 fatty acid stops known trigger of lupus

Print Page
Email Article

"Recovery" from chronic fatigue syndrome after treatments given in the PACE trial.

  [ 9 votes ]   [ 3 Comments ]
By P.D. White et al. • • April 21, 2013

Editor's Comment: This study made worldwide headlines when it was released on January 31, 2013. It is the most recent in a series of studies designed to prove that CBT and GET are effective treatments for CFS/ME. This study has been roundly criticized for statistical sleight of hand: redefinition of "recovery" (recovery was not measured as a return to work, or as physical improvement, but as "normal" fatigue, a term which encompassed moderate disability), the use of self-reporting as a measurement tool, altering the original protocols to "increase accuracy," failure to account for the 78% who did not "recover," failure to define P (the probability of spontaneous improvement after a year), failure to establish a consistent baseline, and the use of the Oxford Case Definition, which does not exclude depression, to establish the original cohort.

Note: The full free paper can be read HERE.

By P.D. White et al.


Background: A multi-centre, four-arm trial (the PACE trial) found that rehabilitative cognitive behaviour therapy (CBT) and graded exercise therapy (GET) were more effective treatments for chronic fatigue syndrome (CFS) than specialist medical care (SMC) alone, when each was added to SMC, and more effective than adaptive pacing therapy (APT) when added to SMC. In this study we compared how many participants recovered after each treatment. Method We defined recovery operationally using multiple criteria, and compared the proportions of participants meeting each individual criterion along with two composite criteria, defined as (a) recovery in the context of the trial and (b) clinical recovery from the current episode of the illness, however defined, 52 weeks after randomization. We used logistic regression modelling to compare treatments.

Results: The percentages (number/total) meeting trial criteria for recovery were 22% (32/143) after CBT, 22% (32/143) after GET, 8% (12/149) after APT and 7% (11/150) after SMC. Similar proportions met criteria for clinical recovery. The odds ratio (OR) for trial recovery after CBT was 3.36 [95% confidence interval (CI) 1.64-6.88] and for GET 3.38 (95% CI 1.65-6.93), when compared to APT, and after CBT 3.69 (95% CI 1.77-7.69) and GET 3.71 (95% CI 1.78-7.74), when compared to SMC (p values ?0.001 for all comparisons). There was no significant difference between APT and SMC. Similar proportions recovered in trial subgroups meeting different definitions of the illness.

Conclusions: This study confirms that recovery from CFS is possible, and that CBT and GET are the therapies most likely to lead to recovery.

Source: Psychol Med. 2013 Jan 31:1-9. [Epub ahead of print] White PD, Goldsmith K, Johnson AL, Chalder T, Sharpe M; PACE Trial Management Group. Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK.

Post a Comment

Featured Products From the ProHealth Store
FibroSleep™ Mitochondria Ignite™ with NT Factor® Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products

Article Comments Post a Comment

The authors
Posted by: IanH
Apr 21, 2013

The relatively small proportion of recovered patients may reflect the heterogeneity of CFS
Reply Reply

Misleading Headline
Posted by: ballard3
Apr 21, 2013
Shouldn't the headline read "Non-recovery from chronic fatigue syndrome after treatments given in the PACE trial"?

Seventy eight percent of the participants did not "recover." Correct me if I'm wrong, but I don't think that "recovery" meant going back to work or resuming an normal life.

Reply Reply

Posted by: leyton
Apr 22, 2013
Having had very severe CFS after Glandular Fever, I am a huge supporter of GET. Having spent two years in bed it was GET that gave me back my life. The CFS/ME community should embrace an essential treatment and not just express their normal knee jerk negative reaction that puts off other CFS patients from committing themselves to a GET program delivered by a trained clinician, and enjoying subsequent benefits.
Reply Reply

Post a Comment

Natural Pain Relief Supplements

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

Astaxanthin - A Little-Known but Power-Packed Nutrient Astaxanthin - A Little-Known but Power-Packed Nutrient
Enhance Eyelashes Naturally Enhance Eyelashes Naturally
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints
Natural Support for Mood, Sleep and Mental Focus? L-theanine Natural Support for Mood, Sleep and Mental Focus? L-theanine
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss

ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
Credit Card Processing
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map