Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Acupuncture used in clinical settings reduced symptoms of menopause

Benefits of Coconut Oil Are Undeniable

How Awesome Is Ashwagandha?

SURVEY RESULTS: Should Opioids Be Restricted for Chronic Illness?

CoQ10 supplementation associated with lower pro-inflammatory factors in randomized trial

Clinical trial demonstrates success of low FODMAP diet

Research Demonstrates Superiority of Krill Oil Compared to Fish Oil

Vitamin nicotinamide riboside protects mice from diabetes complications

What’s so Remarkable About Rosemary?

Vitamin-mineral supplement prevents brain cell loss in recent research

 
Print Page
Email Article

Enhanced Glutathione Levels in Blood and Buccal Cells by Oral Glutathione Supplementation

  [ 8 votes ]   [ Discuss This Article ]
By John P Richie et al. • www.ProHealth.com • June 20, 2013


By John P Richie et al.

Abstract

Glutathione (GSH) is the major antioxidant in nearly all cells and plays numerous roles in protection against diseases and biological insults. Previous studies in laboratory animals indicate that orally administered GSH is bioavailable and effective at enhancing tissue GSH levels. The current objective was to determine the efficacy of GSH supplementation at enhancing body stores of GSH in healthy adults.

We conducted a 6-mo randomized, double-blind, placebo controlled trial to determine the impact of GSH administration at 250 mg/day and 1000 mg/day on GSH levels in different blood components and exfoliated buccal mucosal cells. Subjects were 54 healthy adults (41 females/13 males), 28–72 yr of age (mean=46.6 yr). Compliance was >90% by pill count.

After 6 mo in the high dose group, GSH levels were increased 30–35% in RBC, plasma, and lymphocytes and 260% in buccal cells (P<0.05). In most cases, the increases were dose and time dependent and levels returned to baseline after a 1-month washout. No significant changes were observed in levels of protein bound GSH.

A battery of immune function markers was also examined after 3 mo of GSH supplementation and Natural Killer (NK) cytotoxicity was enhanced > 2-fold in the high dose group (P<0.05). Altogether, these findings are consistent with previous pre-clinical studies and indicate that long-term oral administration GSH is an effective means of enhancing body stores of GSH.

Source: The FASEB Journal. 2013;27:862.32. John P Richie, Sailnendra Nichenametla, Ana Calcagnotto, Wanda Neidig, Todd Schell, and Joshua E Muscat





Post a Comment

Featured Products From the ProHealth Store
Vitamin D3 Extreme™ Ultra EPA  - Fish Oil Optimized Curcumin Longvida®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
All Natural Deodorants

Featured Products

Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Strontium - The Missing Mineral for Strong Bones Strontium - The Missing Mineral for Strong Bones
The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol The Guaifenesin Story: A centuries-old bark extract used for clearing the airways – now key to a popular FM symptom-reversal protocol
Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients Cell-Charging Compound Gives Steady Energy to Fibromyalgia & Chronic Fatigue Patients
Health Benefits Are Brewing in Green Tea Health Benefits Are Brewing in Green Tea
The Fast-Acting Solution for Healthy Digestive Function The Fast-Acting Solution for Healthy Digestive Function

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler

· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map