Activate Now
 
ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

How One LLND Treats Lyme disease and Co-infections Using Natural Medicine

12 Celebrities with Lyme Disease

Single Low-magnitude Electric Pulse Successfully Fights Inflammation

Why Is Spicy Food Good for You?

Parasites and Worms As Major Complicating Co-Factors In Lyme Disease Recovery

How Essential Oils Can Help Improve Your Life

Omega-3 fatty acids may help improve treatment, quality of life in cancer patients

Ask the Doctor- Is it possible to be fully healed from or cured of Lyme Disease?

Clinically Studied Joint Relief Product for FM & ME/CFS

Anti-histamine drug Claritin can kill Borrelia by interfering with manganese utilization

 
Print Page
Email Article

Efficacy and safety of tarenflurbil in mild to moderate Alzheimer's disease: A randomized phase II trial - Source: The Lancet Neurology, June 2008

  [ 152 votes ]   [ Discuss This Article ]
By Gordon K Wilcock, DM, et al. • www.ProHealth.com • June 2, 2008


[Note: this study involved 207 patients. Results of a larger study involving 1800 patients with mild Alzheimer’s expected in 2008.]

Background: The amyloid-ß peptide Aß42 has been implicated in the pathogenesis of Alzheimer's disease (AD). We aimed to test the effects of tarenflurbil [trade name FlurizanTM], a selective Aß42-lowering agent (SALA), on cognition and function in patients with mild to moderate AD.

Methods: 210 patients living in the community who had a mini-mental state examination (MMSE) score of 15-26 were randomly assigned to receive tarenflurbil twice per day (400 mg [n=69] or 800 mg [n=70]) or placebo (n=71) for 12 months in a phase II, multicenter, double-blind study.

Primary efficacy outcomes were the AD assessment scale cognitive subscale (ADAS-cog), the Alzheimer's Disease Cooperative Study activities of daily living scale (ADCS-ADL), and the clinical dementia rating sum of boxes (CDR-sb).

In a 12-month extended treatment phase, patients who had received tarenflurbil continued to receive the same dose, and patients who had received placebo were randomly assigned to tarenflurbil at 800 mg or 400 mg twice per day.

Primary efficacy analyses were done by intention to treat. This trial is registered with Health Canada (084527) and the Medicines and Healthcare products Regulatory Agency in the UK (20365/0001/A 69316).

Findings: A prespecified interaction analysis revealed that patients with mild AD (baseline MMSE 20-26) and moderate AD (baseline MMSE 15-19) responded differently to tarenflurbil in the ADAS-cog and the ADCS-ADL (p=0•10); therefore, these groups were analyzed separately.

Patients with mild AD in the 800 mg tarenflurbil group had lower rates of decline than did those in the placebo group in activities of daily living (ADCS-ADL difference in slope 3•98 [95% CI 0•33 to 7•62] points per year, effect size [reduction from placebo decline rate] 46.4%, Cohen's d 0•45; p=0•033) and global function (CDR-sb difference -0•80 [-1•57 to -0•03] points per year, effect size 35•7%, Cohen's d 0•42; p=0•042); slowing of cognitive decline did not differ significantly (ADAS-cog difference -1•36 [-4.07 to 1.36] points per year, effect size 33.7%, Cohen's d 0•20; p=0•327).

In patients with moderate AD, 800 mg tarenflurbil twice per day had no significant effects on ADCS-ADL and ADAS-cog and had a negative effect on CDR-sb (-52%, Cohen's d -1•08; p=0•003). The most common adverse events were diarrhea (in seven, nine, and five patients in the 800 mg, 400 mg, and placebo groups, respectively), nausea (in seven, seven, and four patients), and dizziness (in five, nine, and four patients).

Patients with mild AD who were in the 800 mg tarenflurbil group for 24 months had lower rates of decline for all three primary outcomes than did patients who were in the placebo group for months 0-12 and a tarenflurbil group for months 12-24 (all p<.0001), and had better outcomes than did patients who were in the placebo group for months 0-12 and the 800 mg tarenflurbil group for months 12-24 (all p<0•05).

Interpretation: 800 mg tarenflurbil twice per day was well tolerated for up to 24 months of treatment, with evidence of a dose-related effect on measures of daily activities and global function in patients with mild AD.

Funding: Myriad Pharmaceuticals.

Source: The Lancet Neurology, June 2008. 7(6):483-493 PMID: 18450517, by Wilcock GK, Black SE, Hendrix SB, Zavitz KH, Swabb EA, Laughlin MA. University of Oxford, John Radcliffe Hospital, Oxford, UK. Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; Myriad Pharmaceuticals, Salt Lake City, Utah, USA. [E-mail: gordon.wilcock@ndm.ox.ac.uk]




Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Nutritional Supplement Orders

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

How Glutathione Can Save Your Life How Glutathione Can Save Your Life
"It's Not Easy Being Green" - But It Is Healthy
Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value Olea25 Olive Hydroxytyrosol Hits Astonishing 68,000+ ORAC Antioxidant Value
Breaking Through the Mental Fog Breaking Through the Mental Fog
Herbal Inflammation Management for Whole Body Health Herbal Inflammation Management for Whole Body Health

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia Diagnosis
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS Diagnosis
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE  |  PRIVACY
CONTACT US
LIBRARY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing