ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Benefits of Coconut Oil Are Undeniable

Acupuncture used in clinical settings reduced symptoms of menopause

CoQ10 supplementation associated with lower pro-inflammatory factors in randomized trial

How Awesome Is Ashwagandha?

SURVEY RESULTS: Should Opioids Be Restricted for Chronic Illness?

Clinical trial demonstrates success of low FODMAP diet

Turmeric: The Spice of Life

Research Demonstrates Superiority of Krill Oil Compared to Fish Oil

What’s so Remarkable About Rosemary?

Vitamin nicotinamide riboside protects mice from diabetes complications

 
Print Page
Email Article

Novel Painkiller has Positive Phase II Clinical Results

  [ 245 votes ]   [ Discuss This Article ]
www.ProHealth.com • October 8, 2001



The drug development company, Pain Therapeutics, Inc., recently announced positive results from preliminary analysis of a large Phase II clinical trial with the drug PTI-555. PTI-555 is an investigational painkiller proposed as a substitute for morphine and similar narcotic painkillers.

This Phase II trial was a multi-center, randomized, double blind, placebo and active controlled human clinical trial comparing PTI-555 to morphine sulfate, and placebo.

The trial enrolled 210 patients with moderate to severe pain following major oral surgery significant enough to warrant opioid analgesia. Immediately after surgery, patients were randomly assigned to receive a single oral nominal dose of PTI-555, morphine sulfate, or placebo.

PTI-555 is a combination of morphine sulfate and low-dose naltrexone. The primary efficacy endpoint in this trial was pain relief within eight hours of dosing.

Patients given a single oral dose of PTI-555 90mg achieved significantly more total pain relief over four hours compared to patients given a single 90mg dose of oral morphine sulfate with no significant change in the incidence of side effects. In addition, patients given a single oral dose of PTI-555 90mg achieved significantly more total pain relief over four hours compared to patients given placebo.

Twenty-five percent of patients given a single oral dose of PTI-555 90mg achieved complete pain relief within eight hours of dosing, compared to just three percent of patients given a single 90mg dose of oral morphine sulfate.

PTI-555 was well tolerated and was not associated with any reported serious adverse events, either during the trial or the subsequent follow-up period. The percentage of patients reporting any drug related adverse events during the 24 hours following dosing was approximately the same in the two drug groups. Certain nervous system conditions, such as somnolence, fatigue, and euphoria, occurred less frequently in the PTI-555 treatment group.

"These positive results are an important clinical milestone for our initiative to develop a drug that's better than morphine," said Barry Sherman, M.D., executive vice president and chief medical officer of Pain Therapeutics, Inc. "The novel pharmacological theory that low doses of opioid antagonist can improve the performance of opioid agonists, such as morphine, continues to be supported in large numbers of patients."



Post a Comment

Featured Products From the ProHealth Store
Mitochondria Ignite™ with NT Factor® Optimized Curcumin Longvida® Ultra EPA  - Fish Oil

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
Dr Axe Bone Broth Proteins

Featured Products

Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid

Natural Remedies

Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry
Safely Burn Away Body Fat Safely Burn Away Body Fat
How Glutathione Can Save Your Life How Glutathione Can Save Your Life
Repair Damaged Mitochondria and Reduce Fatigue Up to 45% Repair Damaged Mitochondria and Reduce Fatigue Up to 45%
The New Dual Activation Pain Relief Cream The New Dual Activation Pain Relief Cream

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE AND SAVE 15% NOW*
Be the first to know about new products, special discounts and the latest health news. *New subscribers only

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map