ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

CDC Whistleblower Reveals Widespread Manipulation of Scientific Data and Top-Down Pressure on CDC Sc...

How Glutathione Can Save Your Life

Reversing Neurodegeneration with a New Magnesium Compound

Gut Bacteria, Artificial Sweeteners and Glucose Intolerance

Brain inflammation dramatically disrupts memory retrieval networks, UCI study finds

Scientists discover how to 'switch off' autoimmune diseases

Clinical trial demonstrates safety, effectiveness of immunotherapy for AdV, BKV, and herpesviruses i...

Surprising discovery: HIV hides in gut, evading eradication

New estrogen-based compound suppresses binge-like eating behavior in female mice

Long-term use of pills for anxiety and sleep problems may be linked to Alzheimer's

 
Print Page
Email Article

Abstract: Treatment of Fibromyalgia with Antidepressants: A Meta-Analysis

  [ 46 votes ]   [ Discuss This Article ]
By P.G. O'Malley, E. Balden, G. Tomkins, J. Santoro, K. Kroenke, J.L. Jackson • www.ProHealth.com • November 7, 2001



Competing interests: None declared

Funding: MacArthur Foundation Initiative on Depression in Primary Care. This digest and commentary appeared in Evidence-Based Medicine, 2001; 6:77

DATA SOURCES
Studies in any language were identified by searching MEDLINE (1966 to June 1999), PsycLIT (1974-1998), and EMBASE/Excerpta Medica (1974-1998) with the terms fibromyalgia, fibrositis, and fibromyositis combined with various terms for antidepressive agents (including specific drug names); the Cochrane Library Clinical Trials Registry and Database of Systematic Reviews; Federal Research in Progress to identify unpublished trials; and bibliographies of reviewed articles.

STUDY SELECTION
Studies were selected if they were randomized, placebo-controlled trials with at least 1 group receiving an antidepressant drug and if they reported measurable outcomes.

DATA EXTRACTION
Data were extracted on setting; country; dose, duration, and follow-up of treatment; number of participants and demographics; assessment of comorbid disease; follow-up losses (i.e., unavailable for follow-up); adverse effects; and outcomes. Methodologic quality of individual trials was assessed using the Jadad scale.

MAIN RESULTS
We included 13 trials (mean sample size, 54; mean duration, 8.1 weeks) in the analysis. Mean quality score for the Jadad scale was 5.6 of a maximum of 8. Nine studies did not give the method of randomization, 7 had no intention-to-treat analysis, 3 inadequately assured blinding effectiveness, 5 did not assess adverse effects, and 6 had lower than 20% loss to follow-up. Trials assessed the efficacy of 3 classes of antidepressant drugs: tricyclic antidepressants (8 trials of amitriptyline hydrochloride, 1 of clomipramine hydrochloride, and 1 of maprotiline hydrochloride), S-adenosyl-1-methionine (2 trials), and selective serotonin reuptake inhibitors (2 of fluoxetine hydrochloride and 1 of citalopram hydrobromide).

Meta-analysis was done using a random-effects model. Meta-analysis of dichotomous outcome data (10 trials) showed that patients who received antidepressants had more symptom improvement than those who received placebo (odds ratio, 4.2 [95% confidence interval (CI), 2.6-6.8]; number needed to treat, 4 [95% CI, 2.9-6.3]). Meta-analysis of continuous outcome data showed that antidepressant drugs were associated with improvements in fatigue scores (8 trials, 0.39 SD unit improvement [95% CI, 0.11-0.66]), sleep scores (8 trials, 0.49 SD unit improvement [95% CI, 0.3-0.69]), pain scores (10 trials, 0.52 SD unit improvement [95% CI, 0.21-0.81]), and overall well-being (7 trials, 0.49 SD unit improvement [95% CI, 0.18-0.80]) but not in the number of trigger points.

CONCLUSION
Antidepressant drugs improve overall symptoms and individual symptoms of fatigue, sleep, and pain in patients with fibromyalgia.











Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Free Shipping on Nutritional Supplement Orders

Featured Products

Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
Supports Cognition, Memory & Overall Health
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength
Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%

Natural Remedies

Broad Spectrum Protection Against Brain Aging Broad Spectrum Protection Against Brain Aging
Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry
IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders IBS, Crohn’s Disease, Colitis, and Other Digestive Disorders
Running on Empty? Fuel Up with NADH Running on Empty? Fuel Up with NADH
Shoo Pain, Don't Bother Me - Top 10 Nutrients to Take Back Your Life Shoo Pain, Don't Bother Me - Top 10 Nutrients to Take Back Your Life

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing