ProHealth health Vitamin and Natural Supplement Store and Health
Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Gut Bacteria, Artificial Sweeteners and Glucose Intolerance

Culprits of Autism Identified: Toxins, Gut Bacteria, Nutritional Deficiencies, and Vaccines Made wit...

Vitamin E intake critical during 'the first 1,000 days'

Turmeric compound boosts regeneration of brain stem cells

Lower risk of mortality over thirteen year period in association with higher levels of vitamin D

Use of Broad-Spectrum Antibiotics Before Age 2 Associated with Obesity Risk

VIDEO: Beautiful Clouds - Relaxation and Meditation

Reverse Mitochondrial Damage

The Fast-Acting Solution for Healthy Digestive Function

Elevated plasma biomarkers of chronic inflammation in Gulf War illness

 
Print Page
Email Article

Abstract: Treatment of Fibromyalgia with Antidepressants: A Meta-Analysis

  [ 46 votes ]   [ Discuss This Article ]
By P.G. O'Malley, E. Balden, G. Tomkins, J. Santoro, K. Kroenke, J.L. Jackson • www.ProHealth.com • November 7, 2001



Competing interests: None declared

Funding: MacArthur Foundation Initiative on Depression in Primary Care. This digest and commentary appeared in Evidence-Based Medicine, 2001; 6:77

DATA SOURCES
Studies in any language were identified by searching MEDLINE (1966 to June 1999), PsycLIT (1974-1998), and EMBASE/Excerpta Medica (1974-1998) with the terms fibromyalgia, fibrositis, and fibromyositis combined with various terms for antidepressive agents (including specific drug names); the Cochrane Library Clinical Trials Registry and Database of Systematic Reviews; Federal Research in Progress to identify unpublished trials; and bibliographies of reviewed articles.

STUDY SELECTION
Studies were selected if they were randomized, placebo-controlled trials with at least 1 group receiving an antidepressant drug and if they reported measurable outcomes.

DATA EXTRACTION
Data were extracted on setting; country; dose, duration, and follow-up of treatment; number of participants and demographics; assessment of comorbid disease; follow-up losses (i.e., unavailable for follow-up); adverse effects; and outcomes. Methodologic quality of individual trials was assessed using the Jadad scale.

MAIN RESULTS
We included 13 trials (mean sample size, 54; mean duration, 8.1 weeks) in the analysis. Mean quality score for the Jadad scale was 5.6 of a maximum of 8. Nine studies did not give the method of randomization, 7 had no intention-to-treat analysis, 3 inadequately assured blinding effectiveness, 5 did not assess adverse effects, and 6 had lower than 20% loss to follow-up. Trials assessed the efficacy of 3 classes of antidepressant drugs: tricyclic antidepressants (8 trials of amitriptyline hydrochloride, 1 of clomipramine hydrochloride, and 1 of maprotiline hydrochloride), S-adenosyl-1-methionine (2 trials), and selective serotonin reuptake inhibitors (2 of fluoxetine hydrochloride and 1 of citalopram hydrobromide).

Meta-analysis was done using a random-effects model. Meta-analysis of dichotomous outcome data (10 trials) showed that patients who received antidepressants had more symptom improvement than those who received placebo (odds ratio, 4.2 [95% confidence interval (CI), 2.6-6.8]; number needed to treat, 4 [95% CI, 2.9-6.3]). Meta-analysis of continuous outcome data showed that antidepressant drugs were associated with improvements in fatigue scores (8 trials, 0.39 SD unit improvement [95% CI, 0.11-0.66]), sleep scores (8 trials, 0.49 SD unit improvement [95% CI, 0.3-0.69]), pain scores (10 trials, 0.52 SD unit improvement [95% CI, 0.21-0.81]), and overall well-being (7 trials, 0.49 SD unit improvement [95% CI, 0.18-0.80]) but not in the number of trigger points.

CONCLUSION
Antidepressant drugs improve overall symptoms and individual symptoms of fatigue, sleep, and pain in patients with fibromyalgia.











Please Discuss This Article:   Post a Comment 



[ Be the first to comment on this article ]




 
Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
Subscribe to
Our FREE
Newsletter
Subscribe Now!
Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
 Privacy Guaranteed  |  View Archives

Save on Vitamins and Supplements

Featured Products

Energy NADH™ 12.5mg Energy NADH™ 12.5mg
Improve Energy & Cognitive Function
FibroSleep™ by ProHealth FibroSleep™ by ProHealth
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing Rejuvenating the Brain - How PQQ Helps Power Up Mental Processing
More Weight Loss than Any Other Discovery in Supplement History More Weight Loss than Any Other Discovery in Supplement History
Research Links Green Tea to Weight Loss Research Links Green Tea to Weight Loss
Dreaming of a Good Night's Sleep? Dreaming of a Good Night's Sleep?
Broad Spectrum Protection Against Brain Aging Broad Spectrum Protection Against Brain Aging

FIBROMYALGIA RESOURCES
What is Fibromyalgia?
Fibromyalgia 101
Fibromyalgia Symptoms
Fibromyalgia Treatments
| CFS RESOURCES
What is CFS?
ME/CFS 101
ME/CFS Symptoms
ME/CFS Treatments
| FORUMS
Fibromyalgia
ME/CFS
ADVANCED MEDICAL LABS
WHOLESALE  |  AFFILIATES
GUARANTEE
CONTACT US
PRIVACY
RSS
SITE MAP
ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
Credit Card Processing