ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

Can Autoimmune Conditions be Reversed? Researchers Make a Surprising Discovery

Scientifically-designed fasting diet lowers risks for major diseases

How One Tiny Molecule Turned into One Huge Health Breakthrough

Acupuncture boosts effectiveness of standard medical care for chronic pain, depression

Research on Astaxanthin Demonstrates Significant Whole Body Benefits

Humans have three times more brown body fat

Nutrients Boost Stem Cell Function

B12 Proven Essential for Every Cell

Soy isoflavones may benefit breast cancer patients

Dietary prebiotics improve sleep, buffer impacts of stress, says study

 
Print Page
Email Article

Popular Painkillers May Prevent Broken Bones From Healing

  [ 145 votes ]   [ Discuss This Article ]
www.ProHealth.com • July 10, 2002


New study findings indicate that popular painkillers such as non-steroidal anti-inflammatory drugs (NSAIDs) like rofecoxib (Vioxx) and celecoxib (Celebrex) may delay or even prevent the healing of broken bones.

"It's time to tell the public," says Thomas Einhorn, an orthopaedic surgeon at Boston University Medical Center and also a paid consultant to Merck, which makes one of the drugs under scrutiny. "It would seem that a prudent approach is to temporarily avoid the use of these drugs during bone healing."

When researcher Patrick O'Connor and his team at the University of New Jersey administered NSAID painkillers to rats their broken bones didn't fully heal. Both drugs, rofecoxib and celecoxib, are often used to ease the pain of arthritis and broken bones.

Merck, the maker of rofecoxib, rejects the claim that healing could be impaired in people too. It pointed out a study on spinal fusion operations that found no bone healing problems in people given rofecoxib. Celecoxib's maker Pharmacia did not respond to queries before the study published in the journal New Scientist went to press.

For over twenty years there have been occasional reports of impaired bone healing in patients taking NSAIDs. The issue may have escaped attention because the older generation of NSAIDS, such as ibuprofen and indomethacin, only appear to delay healing by a few weeks instead of blocking it. Aspirin is one of the few NSAIDs that appears to kill pain without this side effect.

"Ibuprofen and indomethacin delay bone healing by about one to two weeks in rats, which is the equivalent to slowing it down by 25 to 50 per cent in humans," says O'Connor. None of the rats treated with rofecoxib managed to heal their bones. In those treated with celecoxib, none managed to completely heal their bones but about half had some form of bone regrowth.

Traditional NSAIDs inhibit the enzymes cox-1 and cox-2. Cox-2 catalyses the production of hormone-like chemicals known as prostaglandins involved in inflammation, while cox-1 has a variety of roles not specific to the inflammatory response. Since the new generation of NSAIDs such as rofecoxib block cox-2 almost exclusively, it was hoped they would have fewer side effects.

But it now seems that cox-2 may be crucial in helping bone-forming stem cells and growth factors do their work. This area now needs to be investigated urgently, says Jeremy Saklatvala of the Kennedy Institute of Rheumatology in London. "In the meantime, people with healing fractures should steer clear of these drugs."








Post a Comment

Featured Products From the ProHealth Store
Optimized Curcumin Longvida® Ultra ATP+, Double Strength Mitochondria Ignite™ with NT Factor®

Looking for Vitamins, Herbs and Supplements?
Search the ProHealth Store for Hundreds of Natural Health Products


Article Comments



Be the first to comment on this article!

Post a Comment


 
NAD+ Ignite with Niagen

Featured Products

Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
Optimized Curcumin Longvida® Optimized Curcumin Longvida®
Supports Cognition, Memory & Overall Health
Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength

Natural Remedies

Coping When Colds or Flu Catch Up with You Coping When Colds or Flu Catch Up with You
Are You Obtaining the Proper Enzymes? Are You Obtaining the Proper Enzymes?
SAD? Coping with Seasonal Affective Disorder SAD? Coping with Seasonal Affective Disorder
Could a B-12 Deficiency Be Causing Your Symptoms? Could a B-12 Deficiency Be Causing Your Symptoms?
Undenatured Type II Collagen - Chicken Soup for Your Joints Undenatured Type II Collagen - Chicken Soup for Your Joints

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2017 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map