ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help
Facebook Google Plus
Fibromyalgia  Chronic Fatigue Syndrome & M.E.  Lyme Disease  Natural Wellness  Supplement News  Forums  Our Story
Store     Brands   |   A-Z Index   |   Best Sellers   |   New Products   |   Deals & Specials   |   Under $10   |   SmartSavings Club

Trending News

SURVEY: Cognitive Impairment II

Top 3 Nutrients to Detox the Liver and Soothe Digestion

Natural Bladder Control, Go Less and Live More

Study bodes well for low-carb eaters

Top Vitamin and Mineral Deficiencies — Are You at Risk?

Omega Fix for Obesity: How the Right Fats Fight Fat

Potential of Quercetin in the Treatment of Melanoma

How Pomegranate May Protect Against Cancer

Vital Molecule Increases Cellular Energy and Improves Cognitive Function

Trimming the spare tire: Canola oil may cut belly fat

 
Print Page
Email Article

Popular Painkillers May Prevent Broken Bones From Healing

  [ 145 votes ]   [ Discuss This Article ]
www.ProHealth.com • July 10, 2002


New study findings indicate that popular painkillers such as non-steroidal anti-inflammatory drugs (NSAIDs) like rofecoxib (Vioxx) and celecoxib (Celebrex) may delay or even prevent the healing of broken bones.

"It's time to tell the public," says Thomas Einhorn, an orthopaedic surgeon at Boston University Medical Center and also a paid consultant to Merck, which makes one of the drugs under scrutiny. "It would seem that a prudent approach is to temporarily avoid the use of these drugs during bone healing."

When researcher Patrick O'Connor and his team at the University of New Jersey administered NSAID painkillers to rats their broken bones didn't fully heal. Both drugs, rofecoxib and celecoxib, are often used to ease the pain of arthritis and broken bones.

Merck, the maker of rofecoxib, rejects the claim that healing could be impaired in people too. It pointed out a study on spinal fusion operations that found no bone healing problems in people given rofecoxib. Celecoxib's maker Pharmacia did not respond to queries before the study published in the journal New Scientist went to press.

For over twenty years there have been occasional reports of impaired bone healing in patients taking NSAIDs. The issue may have escaped attention because the older generation of NSAIDS, such as ibuprofen and indomethacin, only appear to delay healing by a few weeks instead of blocking it. Aspirin is one of the few NSAIDs that appears to kill pain without this side effect.

"Ibuprofen and indomethacin delay bone healing by about one to two weeks in rats, which is the equivalent to slowing it down by 25 to 50 per cent in humans," says O'Connor. None of the rats treated with rofecoxib managed to heal their bones. In those treated with celecoxib, none managed to completely heal their bones but about half had some form of bone regrowth.

Traditional NSAIDs inhibit the enzymes cox-1 and cox-2. Cox-2 catalyses the production of hormone-like chemicals known as prostaglandins involved in inflammation, while cox-1 has a variety of roles not specific to the inflammatory response. Since the new generation of NSAIDs such as rofecoxib block cox-2 almost exclusively, it was hoped they would have fewer side effects.

But it now seems that cox-2 may be crucial in helping bone-forming stem cells and growth factors do their work. This area now needs to be investigated urgently, says Jeremy Saklatvala of the Kennedy Institute of Rheumatology in London. "In the meantime, people with healing fractures should steer clear of these drugs."








Post a Comment

Featured Products From the ProHealth Store
Ultra EPA  - Fish Oil Mitochondria Ignite™ with NT Factor® Optimized Curcumin Longvida®


Article Comments



Be the first to comment on this article!

Post a Comment


 
Natural Pain Relief Supplements

Featured Products

Vitamin D3 Extreme™ Vitamin D3 Extreme™
50,000 IU Vitamin D3 - Prescription Strength
Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
Reduce Fatigue up to 45%
Ultra ATP+, Double Strength Ultra ATP+, Double Strength
Get energized with malic acid & magnesium
FibroSleep™ FibroSleep™
The All-in-One Natural Sleep Aid
Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
Ultra concentrated source of essential fish oils

Natural Remedies

The Brain Boosting and Fatigue Fighting B-12 The Brain Boosting and Fatigue Fighting B-12
Three-Step Strategy to Reverse Mitochondrial Aging Three-Step Strategy to Reverse Mitochondrial Aging
Vitamin E: Super Antioxidant We Only Thought We Knew Vitamin E: Super Antioxidant We Only Thought We Knew
Why Berries Offer a Rainbow of Health Benefits Why Berries Offer a Rainbow of Health Benefits
Coenzyme Q10 - The Energy Maker Coenzyme Q10 - The Energy Maker

CONTACT US
ProHealth, Inc.
555 Maple Ave
Carpinteria, CA 93013
(800) 366-6056  |  Email

· Become a Wholesaler
· Vendor Inquiries
· Affiliate Program
SHOP WITH CONFIDENCE
Credit Card Processing
SUBSCRIBE TO OUR NEWSLETTERS
Get the latest news about Fibromyalgia, M.E/Chronic Fatigue Syndrome, Lyme Disease and Natural Wellness

CONNECT WITH US ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus

© 2016 ProHealth, Inc. All rights reserved. Pain Tracker App  |  Store  |  Customer Service  |  Guarantee  |  Privacy  |  Contact Us  |  Library  |  RSS  |  Site Map