ProHealth health Vitamin and Natural Supplement Store and Health
Home  |  Log In  |  My Account  |  View Cart  View Your ProHealth Vitamin and Supplement Shopping Cart
800-366-6056  |  Contact Us  |  Help

|
|
|
|

Trending News

Strengthening DNA to Prevent Inflammation, Heart Disease, Dementia and More

Magnesium: Widespread Deficiency with Deadly Consequences

Turmeric compound boosts regeneration of brain stem cells

CoQ10: The Longevity Factor

Culprits of Autism Identified: Toxins, Gut Bacteria, Nutritional Deficiencies, and Vaccines Made wit...

Omega-3 Fatty Acids Increase Brain Volume

Optimal Prostate Defense Requires a Multi-Modal Strategy

Use of Broad-Spectrum Antibiotics Before Age 2 Associated with Obesity Risk

Extending Life and Fighting Disease with Resveratrol

How Lipoic Acid Preserves Critical Mitochondrial Function

 
Print Page
Email Article

Altered intestinal permeability in patients with primary Fibromyalgia and in patients with complex regional pain syndrome – Source: Rheumatology (Oxford), June 7, 2008

  [ 55 votes ]   [ 2 Comments ]
By A Goebel, et al. • www.ProHealth.com • June 20, 2008


[Note: Intestinal permeability – “leaky gut” – is when irritation or damage of the intestinal lining, as from bacterial overgrowth, causes loosening of junctions between the cells, allowing the escape of molecules that would not normally be allowed to pass through to the bloodstream (pathogens, undigested food, toxins) and triggering an immune system response that can cause inflammation in the body. Dr. Kenny De Meirleir's recent reports, for example, point to problems with the intestinal lining in the majority of ME/CFS patients he sees.]

Objectives: The pain intensity of patients with FM has recently been reported to be correlated with the degree of small intestinal bacterial overgrowth (SIBO). SIBO is often associated with an increased intestinal permeability (IP). Increased IP, if shown in FM, may have pathogenetic relevance because it leads to the exposure of immune cells to luminal antigens and consequent immune modulation.

It is currently unknown whether IP is altered in FM. We therefore examined the IP in a group of patients with primary FM and in two control groups - healthy volunteers and patients with an unrelated chronic pain syndrome, complex regional pain syndrome (CRPS).

We hypothesized that patients with FM, but not volunteers or those patients with CRPS, would have altered IP.

Methods: Both gastroduodenal and small IP were assessed using an established three-sugar test, where urinary disaccharide excretion reflecting intestinal uptake was measured using HPLC.

Results: Forty patients with primary FM, 57 age- and sex-matched volunteers and 17 patients with CRPS were enrolled in this study.

  • In the FM group, 13 patients had raised gastroduodenal permeability and 15 patients had raised small intestinal permeability,
  • But only 1 volunteer had increased gastroduodenal permeability (P < 0.0001, chi-square test for the three groups).
  • The IP values were significantly increased in the patient groups (P < 0.0003 for all comparisons, one-way analysis of variance).
  • Conclusions: The IPs in primary FM and, unexpectedly, CRPS are increased.

    This study should stimulate further research to determine the implication of altered IP in the disease pathophysiology of FM and CRPS.

    Source: Rheumatology (Oxford). June 7, 2008. [Epub ahead of print] PMID: 18540025, by Goebel A, Buhner S, Schedel R, Lochs H, Sprotte G. Pain Management Centre, University Hospital Wuerzburg, Wuerzburg; Department for Gastroenterology, Hepatology and Endocrinology, Charite Universitatsmedizin, Berlin, Germany. [E-mail: andreasgoebel@rocketmail.com]




    Please Discuss This Article:   Post a Comment 

    stoumach aches and cervical disc problems
    Posted by: annavirgil
    Jun 25, 2008
    I HAVE FIBROMYALGIA AND SUFFERED TERRIBLY FROM WHAT I THOUGHT WERE STRESS STOUMACH ACHES WHEN I WAS YOUNG. I HAVE HAD SURGERY ON MY CERVICAL DISC AND ALSO THE REST OF MY SPINE. I AM ALSO DIABETIC. I WONDER HOW MANY OTHER PEOPLE OUT THERE WITH FIBROMYALGIA HAVE THESE THINGS GOING ON ALSO. I WAS UNDER TREMENDOUS STRESS WHEN I GOT THE DIAGNOSIS OF FIBROMYALGIA AND SHORTLY THEREAFTER HAD DIABETES AND STARTED HAVING DISC PROBLEMS WITH DEGENERATIVE DISC DISEASE. I HAVE ALWAYS THOUGHT THESE WERE ALL RELATED. MY STRESS LEVELS WERE HIGH WHEN I GOT OLDER WITH THE FIBRO, DISC DISEASE, DIABETES AND "NERVOUS STOUMACH" WHEN ATTEMPTING WHAT I PERCEIVED AS A STRESSFUL SITUATION FOR ME. ANYBODY ELSE OUT THERE HAVE THE SAME PROBLEMS OR SOME COMBINATION OF THESE PROBLEMS? IT DOESNT SURPRISE ME THAT THEY MIGHT BE RELATED TO STOUMACH PROBLEMS.
    Reply Reply

     
    I have the same problems
    Posted by: prazethelord
    Jun 25, 2008
    I have FM and degenterative disk disease and problems with acid reflux and IBS. I don't need to have any stress to bother mine illnesses they flare up all the time. I do not have diabetes but I am hypoglycemic. Everyone is different.

     

     
    Free Chronic Fatigue Syndrome and Fibromyalgia Newsletters
    Subscribe to
    Our FREE
    Newsletter
    Subscribe Now!
    Receive up-to-date ME/CFS & Fibromyalgia treatment and research news
     Privacy Guaranteed  |  View Archives

    Save on Vitamins and Supplements

    Featured Products

    Optimized Curcumin Longvida® by ProHealth Optimized Curcumin Longvida® by ProHealth
    Supports Cognition, Memory & Overall Health
    Ultra ATP+, Double Strength Ultra ATP+, Double Strength
    Get energized with malic acid & magnesium
    Vitamin D3 Extreme™ by ProHealth Vitamin D3 Extreme™ by ProHealth
    50,000 IU Vitamin D3 - Prescription Strength
    Ultra EPA  - Fish Oil Ultra EPA - Fish Oil
    Ultra concentrated source of essential fish oils
    Mitochondria Ignite™ with NT Factor® Mitochondria Ignite™ with NT Factor®
    Reduce Fatigue up to 45%

    Natural Remedies

    Itching to Find Dry Skin Relief? Itching to Find Dry Skin Relief?
    Fatigue & Fibro Fog: Could You Have a B-12 Deficiency? Fatigue & Fibro Fog: Could You Have a B-12 Deficiency?
    The Big Blue Fish that Helps Chase the Blues Away The Big Blue Fish that Helps Chase the Blues Away
    "It's Not Easy Being Green" - But It Is Healthy
    Anti-Inflammatory Properties of Tart Cherry Anti-Inflammatory Properties of Tart Cherry

    FIBROMYALGIA RESOURCES
    What is Fibromyalgia?
    Fibromyalgia 101
    Fibromyalgia Symptoms
    Fibromyalgia Treatments
    | CFS RESOURCES
    What is CFS?
    ME/CFS 101
    ME/CFS Symptoms
    ME/CFS Treatments
    | FORUMS
    Fibromyalgia
    ME/CFS
    ADVANCED MEDICAL LABS
    WHOLESALE  |  AFFILIATES
    GUARANTEE
    CONTACT US
    PRIVACY
    RSS
    SITE MAP
    ProHealth on Facebook  ProHealth on Twitter  ProHealth on Pinterest  ProHealth on Google Plus
    Credit Card Processing